Unraveling the synthetic strategy, structure activity relationship of azetidinones: Insights into their multidrug and toxin extrusion protein (MATE transporter) inhibition facilitating drug development against MDR - Mal, Suvadeep; Mahapatra, Monalisa; Pakeeraiah, Kakarla; Panda, Preetesh Kumar; Sahoo, Jyotirmaya; Roy, Partha; Paidesetty, Sudhir Kumar (Bioorganic chemistry, 2025)
Keywords: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Azetidines - chemical synthesis; Azetidines - chemistry; Azetidines - pharmacology; Azetidinone; Cancer; Drug Development; Drug Resistance, Multiple, Bacterial - drug effects; Humans; MATE transporter inhibitor; Microbial; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Multidrug resistance; SAR; Structure-Activity Relationship; β-lactam; MAT; AcOH; SAR; HOMO; LUMO; DABCO; ADMET; EGFR; THF; Rh; IC50; Ph; DMAP; EC50; CA-4; Microbial; DMF; MATE transporter inhibitor; HPLC; nM; CuBr; AcONa; DILI; DCC; MIC; Multidrug resistance; DIPEA; POCl3; LiHMDS; β-lactam; DCM; Naph; LD50; TEA; LC50; ZOI; CuI; ROS; µM; AMPK; Azetidinone; CuCl; IPA; Cancer