Proton therapy re-irradiation outcomes and genomic landscape of patients with recurrent head and neck cancer

• Published in: Oral oncology Vol. 154; p. 106875
• Main Authors: Krc, Rebecca, Mendes, William, Molitoris, Jason, Ferris, Matthew, Song, Yang, Shetty, Amol, Mehra, Ranee, Papadimitriou, John C., Hatten, Kyle, Taylor, Rodney, Wolf, Jeffrey, Sun, Kai, Bentzen, Soren, Regine, William, Tran, Phuoc, Witek, Matthew
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2024
• Subjects: Adult; Aged; Aged, 80 and over; Female; Genomics; Genomics - methods; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - radiotherapy; Humans; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - radiotherapy; Pencil beam scanning; Proton therapy; Proton Therapy - adverse effects; Proton Therapy - methods; Re-Irradiation - methods; Recurrent head and neck cancer; Retrospective Studies; Toxicity; Treatment Outcome; Recurrent head and neck cancer; Proton therapy; Pencil beam scanning; Toxicity; Genomics

•Re-irradiation (re-RT) for recurrent head and neck cancer (rHNC) is clinically challenging.•Methods to better select patients for re-RT is of paramount importance.•Proton therapy re-RT of rHNC affords good local control and an acceptable toxicity profile.•Distant failures are common, and are associ...