FAHFA promotes intracellular calcium signaling via activating the fat taste receptor, CD36 and Src protein kinases in mice taste bud cells

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 12; p. 130722
• Main Authors: Muthuswamy, Karthi, Vasanthakumar, Keerthana, Panneerselvan, Prabha, Thangamani, Lokesh, Krishnan, Vasanth, Piramanayagam, Shanmughavel, Subramaniam, Selvakumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024
• Subjects: Animals; Calcium - metabolism; Calcium Signaling; CD36; CD36 Antigens - metabolism; FAHFAs; Fat; GPR120; Male; Mice; Mice, Inbred C57BL; Receptors, G-Protein-Coupled - metabolism; src-Family Kinases - metabolism; Taste - physiology; Taste Buds - metabolism; Fat; FAHFAs; GPR120; CD36

Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to...