FAHFA promotes intracellular calcium signaling via activating the fat taste receptor, CD36 and Src protein kinases in mice taste bud cells
Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to...
Saved in:
| Published in | Biochimica et biophysica acta. General subjects Vol. 1868; no. 12; p. 130722 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.12.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs). The Schrodinger platform was used to assess the molecular dynamics of protein and ligand interactions, and an in vitro experiment was used to validate the findings. Based on the docking score of the ligand, the molecular mechanistic activities of the targeted complexes, CD36–5-POHSA (−8.2 kcal/mol), were investigated using the dynamic simulation. In comparison to linoleic acid (LA), POHSA rapidly increased [Ca2+]i via acting on CD36, and 5-POHSA treatment in mTBCs activated src-kinase at 20 μM. CD36 siRNA transfection in TBCs downregulate the CD36 protein expression as well as [Ca2+]i flux. This study suggests that 5-POHSA may help combat taste abnormalities and the adverse effects of obesity by binding to the lingual CD36 receptor and activating the tongue-brain axis.
•Targeting fat taste offers a potential therapeutic avenue for reducing body weight and fat consumption.•Studies on mouse fungiform taste bud cells reveal dose-dependent calcium responses to fat taste agonists, highlighting the role of CD36 activation.•Src family kinases play a crucial role in fat-tasting impacts, potentially through CD36 activation. |
|---|---|
| AbstractList | Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs). The Schrodinger platform was used to assess the molecular dynamics of protein and ligand interactions, and an in vitro experiment was used to validate the findings. Based on the docking score of the ligand, the molecular mechanistic activities of the targeted complexes, CD36–5-POHSA (−8.2 kcal/mol), were investigated using the dynamic simulation. In comparison to linoleic acid (LA), POHSA rapidly increased [Ca2+]i via acting on CD36, and 5-POHSA treatment in mTBCs activated src-kinase at 20 μM. CD36 siRNA transfection in TBCs downregulate the CD36 protein expression as well as [Ca2+]i flux. This study suggests that 5-POHSA may help combat taste abnormalities and the adverse effects of obesity by binding to the lingual CD36 receptor and activating the tongue-brain axis.
•Targeting fat taste offers a potential therapeutic avenue for reducing body weight and fat consumption.•Studies on mouse fungiform taste bud cells reveal dose-dependent calcium responses to fat taste agonists, highlighting the role of CD36 activation.•Src family kinases play a crucial role in fat-tasting impacts, potentially through CD36 activation. Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs). The Schrodinger platform was used to assess the molecular dynamics of protein and ligand interactions, and an in vitro experiment was used to validate the findings. Based on the docking score of the ligand, the molecular mechanistic activities of the targeted complexes, CD36-5-POHSA (-8.2 kcal/mol), were investigated using the dynamic simulation. In comparison to linoleic acid (LA), POHSA rapidly increased [Ca2+]i via acting on CD36, and 5-POHSA treatment in mTBCs activated src-kinase at 20 μM. CD36 siRNA transfection in TBCs downregulate the CD36 protein expression as well as [Ca2+]i flux. This study suggests that 5-POHSA may help combat taste abnormalities and the adverse effects of obesity by binding to the lingual CD36 receptor and activating the tongue-brain axis.Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs). The Schrodinger platform was used to assess the molecular dynamics of protein and ligand interactions, and an in vitro experiment was used to validate the findings. Based on the docking score of the ligand, the molecular mechanistic activities of the targeted complexes, CD36-5-POHSA (-8.2 kcal/mol), were investigated using the dynamic simulation. In comparison to linoleic acid (LA), POHSA rapidly increased [Ca2+]i via acting on CD36, and 5-POHSA treatment in mTBCs activated src-kinase at 20 μM. CD36 siRNA transfection in TBCs downregulate the CD36 protein expression as well as [Ca2+]i flux. This study suggests that 5-POHSA may help combat taste abnormalities and the adverse effects of obesity by binding to the lingual CD36 receptor and activating the tongue-brain axis. Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs). The Schrodinger platform was used to assess the molecular dynamics of protein and ligand interactions, and an in vitro experiment was used to validate the findings. Based on the docking score of the ligand, the molecular mechanistic activities of the targeted complexes, CD36-5-POHSA (-8.2 kcal/mol), were investigated using the dynamic simulation. In comparison to linoleic acid (LA), POHSA rapidly increased [Ca ]i via acting on CD36, and 5-POHSA treatment in mTBCs activated src-kinase at 20 μM. CD36 siRNA transfection in TBCs downregulate the CD36 protein expression as well as [Ca ]i flux. This study suggests that 5-POHSA may help combat taste abnormalities and the adverse effects of obesity by binding to the lingual CD36 receptor and activating the tongue-brain axis. |
| ArticleNumber | 130722 |
| Author | Vasanthakumar, Keerthana Panneerselvan, Prabha Thangamani, Lokesh Subramaniam, Selvakumar Piramanayagam, Shanmughavel Muthuswamy, Karthi Krishnan, Vasanth |
| Author_xml | – sequence: 1 givenname: Karthi surname: Muthuswamy fullname: Muthuswamy, Karthi organization: Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 2 givenname: Keerthana surname: Vasanthakumar fullname: Vasanthakumar, Keerthana organization: Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 3 givenname: Prabha surname: Panneerselvan fullname: Panneerselvan, Prabha organization: Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 4 givenname: Lokesh surname: Thangamani fullname: Thangamani, Lokesh organization: Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 5 givenname: Vasanth surname: Krishnan fullname: Krishnan, Vasanth organization: Molecular Biology Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 6 givenname: Shanmughavel surname: Piramanayagam fullname: Piramanayagam, Shanmughavel organization: Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu 641046, India – sequence: 7 givenname: Selvakumar surname: Subramaniam fullname: Subramaniam, Selvakumar email: selvs20@yahoo.com organization: Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamilnadu 641046, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39426759$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU2P0zAQtdAitrvwDxDykQMpduzm44JUdeku0kocgLM1mYyLS-IU26nEX-BXk5AuR-ZijfQ-xu_dsCs_eGLstRRrKWTx_rhuGjiQX-ci12upRJnnz9hKVmWeVUIUV2wllNCZlsXmmt3EeBTTbOrNC3atap0X5aZesd_77cN-y09h6IdEkTufAiB13dhB4AgdurHn0R08dM4f-NkBB0zuDGle03fiFhJPEBPxQEinNIR3fHenCg6-5V8CzuKJnOc_nIf414P3DulCasaWz4bxJXtuoYv06vLesm_7j193D9nj5_tPu-1jhkrKlOnGlrXGvNIiV6hsIRqwFSpRg9TtFEMrrS2xsoBFI7ESpajqFkmgBdlCrm7Z20V3uuvnSDGZ3sX5AvA0jNFMLpUupVIz9M0FOjY9teYUXA_hl3nKbwLoBYBhiDGQ_QeRwsw1maNZajJzTWapaaJ9WGg0_fPsKJiIjjxS66YMk2kH93-BP0tLnTs |
| Cites_doi | 10.1172/JCI129187 10.1074/jbc.M311274200 10.1021/jm051256o 10.1111/nbu.12633 10.3389/fphys.2020.00825 10.1021/ci049714+ 10.1074/jbc.M707478200 10.1016/j.jnutbio.2024.109619 10.1111/nyas.14752 10.1126/scisignal.272re3 10.1074/jbc.M405280200 10.1016/j.neuroscience.2013.06.043 10.3945/ajcn.110.007583 10.1080/19490976.2017.1290756 10.1016/j.plipres.2013.11.001 10.1016/j.jcmgh.2022.11.003 10.1016/j.jacc.2018.02.055 10.1111/apha.13215 10.1161/CIRCULATIONAHA.107.739714 10.3945/ajcn.113.077198 10.1038/s41586-021-04075-0 10.1096/fj.07-8415com 10.1016/j.cell.2014.09.035 10.1523/JNEUROSCI.0496-10.2010 10.1016/j.tifs.2022.11.005 10.1016/j.plipres.2011.02.002 10.1016/j.focha.2022.100040 10.1053/j.gastro.2014.01.006 10.1194/jlr.RA119000142 10.1096/fj.201600422R 10.1074/jbc.272.47.29434 10.1152/physrev.00002.2015 10.1016/j.biochi.2017.03.004 10.1016/j.foodres.2022.112294 10.1101/cshperspect.a006627 10.1016/j.plipres.2020.101032 10.1038/sj.emboj.7601049 10.3389/fimmu.2023.1224092 10.1007/s00125-010-1832-7 10.1038/s41598-018-34113-3 10.1074/jbc.M115.703835 10.1016/j.jlr.2021.100108 |
| ContentType | Journal Article |
| Copyright | 2024 Copyright © 2024. Published by Elsevier B.V. |
| Copyright_xml | – notice: 2024 – notice: Copyright © 2024. Published by Elsevier B.V. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.bbagen.2024.130722 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1872-8006 |
| ExternalDocumentID | 39426759 10_1016_j_bbagen_2024_130722 S030441652400165X |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFJKZ AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 EBS EFJIC EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AATTM AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c311t-4bf794c284023c3f60baf8c309a14d307d1ff7c8fac6b1c807089dce0cfa1da23 |
| IEDL.DBID | .~1 |
| ISSN | 0304-4165 1872-8006 |
| IngestDate | Fri Jul 11 10:32:08 EDT 2025 Fri May 30 10:59:47 EDT 2025 Tue Jul 01 00:22:20 EDT 2025 Sat Nov 09 16:00:11 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | Fat FAHFAs GPR120 CD36 |
| Language | English |
| License | Copyright © 2024. Published by Elsevier B.V. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c311t-4bf794c284023c3f60baf8c309a14d307d1ff7c8fac6b1c807089dce0cfa1da23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 39426759 |
| PQID | 3118471332 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3118471332 pubmed_primary_39426759 crossref_primary_10_1016_j_bbagen_2024_130722 elsevier_sciencedirect_doi_10_1016_j_bbagen_2024_130722 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2024 2024-12-00 20241201 |
| PublicationDateYYYYMMDD | 2024-12-01 |
| PublicationDate_xml | – month: 12 year: 2024 text: December 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta. General subjects |
| PublicationTitleAlternate | Biochim Biophys Acta Gen Subj |
| PublicationYear | 2024 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Cartoni, Yasumatsu, Ohkuri, Shigemura, Yoshida, Godinot, Le Coutre, Ninomiya, Damak (bb0060) 2010; 30 Gaillard, Laugerette, Darcel, El-Yassimi, Passilly-Degrace, Hichami, Khan, Montmayeur, Besnard (bb0160) 2008; 22 Ozdener, Subramaniam, Sundaresan, Sery, Hashimoto, Asakawa, Besnard, Abumrad, Khan (bb0010) 2014; 146 Aryal, Syed, Lee, Patel, Nelson, Siegel, Saghatelian, Kahn (bb0190) 2021; 62 Khan, Hichami, Murtaza, Louillat-Habermeyer, Ramseyer, Azadi, Yesylevskyy, Mangin, Lirussi, Leemput (bb0045) 2023; 15 Mongraw-Chaffin, Foster, Anderson, Burke, Haq, Kalyani, Ouyang, Sibley, Tracy, Woodward, Vaidya (bb0145) 2018; 71 Besnard, Passilly-Degrace, Khan (bb0035) 2015; 96 Lee, Moraes-Vieira, Castoldi, Aryal, Yee, Vickers, Parnas, Donaldson, Saghatelian, Kahn (bb0070) 2016; 291 Hisatsune, Kuroda, Nakamura, Inoue, Nakamura, Michikawa, Mizutani, Mikoshiba (bb0220) 2004; 279 Subramaniam, Ozdener, Abdoul-Azize, Saito, Malik, Maquart, Hashimoto, Marambaud, Aribi, Tordoff (bb0015) 2016; 30 Subramanian, Ponnusamy, Vasanthakumar, Panneerselvan, Krishnan, Subramaniam (bb0020) 2024; 128 Gilbertson, Khan (bb0180) 2014; 53 Godinot, Yasumatsu, Barcos, Pineau, Ledda, Viton, Ninomiya, Le Coutre, Damak (bb0105) 2013; 250 Lawler, Lawler (bb0085) 2012; 2 Khan, Keast, Khan (bb0030) 2020; 78 Vazquez, Wedel, Kawasaki, Bird, Putney (bb0225) 2004; 279 Holscher (bb0095) 2017; 8 DeVito, Dennis, Kahn, Shulman, Witztum, Sadhu, Nickels, Spite, Smyth, Spiegel (bb0195) 2022; 1511 Stewart, Seimon, Otto, Keast, Clifton, Feinle-Bisset (bb0150) 2011; 93 Kahn, Wang, Lee (bb0200) 2019; 129 Chevrot, Passilly-Degrace, Ancel, Bernard, Enderli, Gomes, Robin, Issanchou, Vergès, Nicklaus, Besnard (bb0155) 2014; 99 Silverstein, Febbraio (bb0170) 2009; 2 Schwenk, Dirkx, Coumans, Bonen, Klip, Glatz, Luiken (bb0210) 2010; 53 Sheng, Ji, Zhang (bb0100) 2023; 14 Irwin, Shoichet (bb0115) 2005; 45 Muthuswamy, Shanmugamprema, Ponnusamy, Subramanian, Krishnan, Palanivelu, Rajasekaran, Subramaniam (bb0075) 2021 Meisel, Pagella, Porcheri, Mitsiadis (bb0125) 2020; 11 Yore, Syed, Moraes-Vieira, Zhang, Herman, Homan, Patel, Lee, Chen, Peroni (bb0065) 2014; 159 Pascual, Domínguez, Elosúa-Bayes, Beckedorff, Laudanna, Bigas, Douillet, Greco, Symeonidi, Hernández (bb0130) 2021; 599 Stewart, Feinle-Bisset, Keast (bb0040) 2011; 50 Watanabe, Balas, Saigusa, Ogura, Durand, Mano, Yamaguchi (bb0110) 2022; 1 Friesner, Murphy, Repasky, Frye, Greenwood, Halgren, Sanschagrin, Mainz (bb0120) 2006; 49 Ponnusamy, Subramanian, Vasanthakumar, Muthuswamy, Panneerselvan, Krishnan, Subramaniam (bb0025) 2024 El-Yassimi, Hichami, Besnard, Khan (bb0175) 2008; 283 Houten, Watanabe, Auwerx (bb0205) 2006; 25 Murtaza, Hichami, Khan, Shimpukade, Ulven, Ozdener, Khan (bb0055) 2020; 61 Babnigg, Bowersox, Villereal (bb0230) 1997; 272 Khan, Subramaniam, Dramane, Khelif, Khan (bb0135) 2017; 137 Zhang, Rexrode, Van Dam, Li, Hu (bb0140) 2008; 117 Olajide, Cao (bb0185) 2022; 129 Yasumatsu, Iwata, Inoue, Ninomiya (bb0165) 2019; 226 Silverstein, Li, Park, Rahaman (bb0090) 2010; 121 Muthuswamy, Shanmugamprema, Subramanian, Ponnusamy, Vasanthakumar, Krishnan, Palanivelu, Rajasekaran, Subramaniam (bb0080) 2023; 48 Ponnusamy, Subramanian, Muthuswamy, Shanmugamprema, Vasanthakumar, Krishnan, Subramaniam (bb0005) 2023; 163 Hammarstedt, Syed, Vijayakumar, Eliasson, Gogg, Kahn, Smith (bb0050) 2018; 8 Hisatsune (10.1016/j.bbagen.2024.130722_bb0220) 2004; 279 Friesner (10.1016/j.bbagen.2024.130722_bb0120) 2006; 49 DeVito (10.1016/j.bbagen.2024.130722_bb0195) 2022; 1511 Kahn (10.1016/j.bbagen.2024.130722_bb0200) 2019; 129 Gaillard (10.1016/j.bbagen.2024.130722_bb0160) 2008; 22 Watanabe (10.1016/j.bbagen.2024.130722_bb0110) 2022; 1 Stewart (10.1016/j.bbagen.2024.130722_bb0150) 2011; 93 Cartoni (10.1016/j.bbagen.2024.130722_bb0060) 2010; 30 Aryal (10.1016/j.bbagen.2024.130722_bb0190) 2021; 62 Ponnusamy (10.1016/j.bbagen.2024.130722_bb0025) 2024 Zhang (10.1016/j.bbagen.2024.130722_bb0140) 2008; 117 Vazquez (10.1016/j.bbagen.2024.130722_bb0225) 2004; 279 Silverstein (10.1016/j.bbagen.2024.130722_bb0090) 2010; 121 Khan (10.1016/j.bbagen.2024.130722_bb0030) 2020; 78 Holscher (10.1016/j.bbagen.2024.130722_bb0095) 2017; 8 Meisel (10.1016/j.bbagen.2024.130722_bb0125) 2020; 11 Lawler (10.1016/j.bbagen.2024.130722_bb0085) 2012; 2 Subramanian (10.1016/j.bbagen.2024.130722_bb0020) 2024; 128 Sheng (10.1016/j.bbagen.2024.130722_bb0100) 2023; 14 Ozdener (10.1016/j.bbagen.2024.130722_bb0010) 2014; 146 Subramaniam (10.1016/j.bbagen.2024.130722_bb0015) 2016; 30 Khan (10.1016/j.bbagen.2024.130722_bb0045) 2023; 15 Murtaza (10.1016/j.bbagen.2024.130722_bb0055) 2020; 61 Schwenk (10.1016/j.bbagen.2024.130722_bb0210) 2010; 53 El-Yassimi (10.1016/j.bbagen.2024.130722_bb0175) 2008; 283 Chevrot (10.1016/j.bbagen.2024.130722_bb0155) 2014; 99 Ponnusamy (10.1016/j.bbagen.2024.130722_bb0005) 2023; 163 Stewart (10.1016/j.bbagen.2024.130722_bb0040) 2011; 50 Lee (10.1016/j.bbagen.2024.130722_bb0070) 2016; 291 Muthuswamy (10.1016/j.bbagen.2024.130722_bb0080) 2023; 48 Silverstein (10.1016/j.bbagen.2024.130722_bb0170) 2009; 2 Olajide (10.1016/j.bbagen.2024.130722_bb0185) 2022; 129 Pascual (10.1016/j.bbagen.2024.130722_bb0130) 2021; 599 Khan (10.1016/j.bbagen.2024.130722_bb0135) 2017; 137 Mongraw-Chaffin (10.1016/j.bbagen.2024.130722_bb0145) 2018; 71 Gilbertson (10.1016/j.bbagen.2024.130722_bb0180) 2014; 53 Irwin (10.1016/j.bbagen.2024.130722_bb0115) 2005; 45 Besnard (10.1016/j.bbagen.2024.130722_bb0035) 2015; 96 Godinot (10.1016/j.bbagen.2024.130722_bb0105) 2013; 250 Hammarstedt (10.1016/j.bbagen.2024.130722_bb0050) 2018; 8 Muthuswamy (10.1016/j.bbagen.2024.130722_bb0075) 2021 Yasumatsu (10.1016/j.bbagen.2024.130722_bb0165) 2019; 226 Yore (10.1016/j.bbagen.2024.130722_bb0065) 2014; 159 Houten (10.1016/j.bbagen.2024.130722_bb0205) 2006; 25 Babnigg (10.1016/j.bbagen.2024.130722_bb0230) 1997; 272 |
| References_xml | – volume: 129 year: 2022 ident: bb0185 article-title: Exploring foods as natural sources of FAHFAs—A review of occurrence, extraction, analytical techniques and emerging bioactive potential publication-title: Trends Food Sci. Technol. – volume: 279 start-page: 40521 year: 2004 end-page: 40528 ident: bb0225 article-title: Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels publication-title: J. Biol. Chem. – volume: 30 year: 2010 ident: bb0060 article-title: Taste preference for fatty acids is mediated by GPR40 and GPR120 publication-title: J. Neurosci. – volume: 129 year: 2019 ident: bb0200 article-title: Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome publication-title: J. Clin. Investig. – volume: 62 year: 2021 ident: bb0190 article-title: Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs) publication-title: J. Lipid Res. – volume: 226 year: 2019 ident: bb0165 article-title: Fatty acid taste quality information via GPR120 in the anterior tongue of mice publication-title: Acta Physiol. – volume: 45 year: 2005 ident: bb0115 article-title: ZINC - a free database of commercially available compounds for virtual screening publication-title: J. Chem. Inf. Model. – volume: 272 start-page: 29434 year: 1997 end-page: 29437 ident: bb0230 article-title: The role of pp60c-src in the regulation of calcium entry via store-operated calcium channels publication-title: J. Biol. Chem. – volume: 48 start-page: 376 year: 2023 end-page: 389 ident: bb0080 article-title: CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake publication-title: Nutr. Bull. – volume: 71 year: 2018 ident: bb0145 article-title: Metabolically healthy obesity, transition to metabolic syndrome, and cardiovascular risk publication-title: J. Am. Coll. Cardiol. – volume: 49 start-page: 6177 year: 2006 end-page: 6196 ident: bb0120 article-title: Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein− ligand complexes publication-title: J. Med. Chem. – volume: 93 year: 2011 ident: bb0150 article-title: Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men publication-title: Am. J. Clin. Nutr. – volume: 8 start-page: 172 year: 2017 ident: bb0095 article-title: Dietary fiber and prebiotics and the gastrointestinal microbiota publication-title: Gut Microbes – volume: 1 year: 2022 ident: bb0110 article-title: Analytical evaluation of fatty acid esters of hydroxy fatty acid quantity in fermented brown rice and rice bran (FRBA) publication-title: Food Chem. Adv. – volume: 61 start-page: 133 year: 2020 end-page: 142 ident: bb0055 article-title: Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice publication-title: J. Lipid Res. – volume: 96 start-page: 151 year: 2015 end-page: 176 ident: bb0035 article-title: Taste of fat: a sixth taste modality? publication-title: Physiol. Rev. – volume: 8 start-page: 15757 year: 2018 ident: bb0050 article-title: Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids publication-title: Sci. Rep. – volume: 2 year: 2012 ident: bb0085 article-title: Molecular basis for the regulation of angiogenesis by thrombospondin-1 and-2 publication-title: Cold Spring Harb. Perspect. Med. – volume: 599 start-page: 485 year: 2021 end-page: 490 ident: bb0130 article-title: Dietary palmitic acid promotes a prometastatic memory via Schwann cells publication-title: Nature – volume: 53 year: 2014 ident: bb0180 article-title: Cell signaling mechanisms of oro-gustatory detection of dietary fat: advances and challenges publication-title: Prog. Lipid Res. – volume: 30 start-page: 3489 year: 2016 ident: bb0015 article-title: ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans publication-title: FASEB J. – volume: 50 start-page: 225 year: 2011 end-page: 233 ident: bb0040 article-title: Fatty acid detection during food consumption and digestion: associations with ingestive behavior and obesity publication-title: Prog. Lipid Res. – volume: 291 start-page: 22207 year: 2016 end-page: 22217 ident: bb0070 article-title: Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses publication-title: J. Biol. Chem. – volume: 25 year: 2006 ident: bb0205 article-title: Endocrine functions of bile acids publication-title: EMBO J. – volume: 159 start-page: 318 year: 2014 end-page: 332 ident: bb0065 article-title: Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects publication-title: Cell – volume: 22 year: 2008 ident: bb0160 article-title: The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse publication-title: FASEB J. – volume: 121 start-page: 206 year: 2010 ident: bb0090 article-title: Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis publication-title: Trans. Am. Clin. Climatol. Assoc. – volume: 1511 year: 2022 ident: bb0195 article-title: Bioactive lipids and metabolic syndrome—a symposium report publication-title: Ann. N. Y. Acad. Sci. – volume: 117 year: 2008 ident: bb0140 article-title: Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women publication-title: Circulation – volume: 283 year: 2008 ident: bb0175 article-title: Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells publication-title: J. Biol. Chem. – volume: 250 start-page: 20 year: 2013 end-page: 30 ident: bb0105 article-title: Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice publication-title: Neuroscience – volume: 78 year: 2020 ident: bb0030 article-title: Preference for dietary fat: from detection to disease publication-title: Prog. Lipid Res. – volume: 11 start-page: 825 year: 2020 ident: bb0125 article-title: Three-dimensional imaging and gene expression analysis upon enzymatic isolation of the tongue epithelium publication-title: Front. Physiol. – volume: 279 start-page: 18887 year: 2004 end-page: 18894 ident: bb0220 article-title: Regulation of TRPC6 channel activity by tyrosine phosphorylation publication-title: J. Biol. Chem. – volume: 137 start-page: 78 year: 2017 end-page: 87 ident: bb0135 article-title: ERK1 and ERK2 activation modulates diet-induced obesity in mice publication-title: Biochimie – volume: 53 year: 2010 ident: bb0210 article-title: Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes publication-title: Diabetologia – year: 2021 ident: bb0075 article-title: Single nucleotide polymorphism in CD36: correlation to peptide YY levels in obese and non-obese adults publication-title: Clin. Nutr. – start-page: 1 year: 2024 end-page: 16 ident: bb0025 article-title: T1R2/T1R3 polymorphism affects sweet and fat perception: correlation between SNP and BMI in the context of obesity development publication-title: Hum. Genet. – volume: 15 start-page: 633 year: 2023 end-page: 663 ident: bb0045 article-title: Novel fat taste receptor agonists curtail progressive weight gain in obese male mice publication-title: Cell Mol. Gastroenterol. Hepatol. – volume: 14 year: 2023 ident: bb0100 article-title: Immunomodulatory effects of inulin and its intestinal metabolites publication-title: Front. Immunol. – volume: 163 year: 2023 ident: bb0005 article-title: Tongue papillae density and fat taster status- a cardinal role on sweet and bitter taste perception among Indian population publication-title: Food Res. Int. – volume: 146 year: 2014 ident: bb0010 article-title: CD36- and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice publication-title: Gastroenterology – volume: 99 year: 2014 ident: bb0155 article-title: Obesity interferes with the orosensory detection of long-chain fatty acids in humans publication-title: Am. J. Clin. Nutr. – volume: 2 year: 2009 ident: bb0170 article-title: CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior publication-title: Sci. Signal. – volume: 128 year: 2024 ident: bb0020 article-title: The gustin gene variation at rs2274333 and PROP taster status affect dietary fat perception: a stepwise multiple regression model study publication-title: J. Nutr. Biochem. – volume: 129 year: 2019 ident: 10.1016/j.bbagen.2024.130722_bb0200 article-title: Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome publication-title: J. Clin. Investig. doi: 10.1172/JCI129187 – volume: 279 start-page: 18887 year: 2004 ident: 10.1016/j.bbagen.2024.130722_bb0220 article-title: Regulation of TRPC6 channel activity by tyrosine phosphorylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M311274200 – volume: 49 start-page: 6177 year: 2006 ident: 10.1016/j.bbagen.2024.130722_bb0120 article-title: Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein− ligand complexes publication-title: J. Med. Chem. doi: 10.1021/jm051256o – volume: 48 start-page: 376 year: 2023 ident: 10.1016/j.bbagen.2024.130722_bb0080 article-title: CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake publication-title: Nutr. Bull. doi: 10.1111/nbu.12633 – volume: 11 start-page: 825 year: 2020 ident: 10.1016/j.bbagen.2024.130722_bb0125 article-title: Three-dimensional imaging and gene expression analysis upon enzymatic isolation of the tongue epithelium publication-title: Front. Physiol. doi: 10.3389/fphys.2020.00825 – volume: 45 year: 2005 ident: 10.1016/j.bbagen.2024.130722_bb0115 article-title: ZINC - a free database of commercially available compounds for virtual screening publication-title: J. Chem. Inf. Model. doi: 10.1021/ci049714+ – volume: 283 year: 2008 ident: 10.1016/j.bbagen.2024.130722_bb0175 article-title: Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M707478200 – volume: 128 year: 2024 ident: 10.1016/j.bbagen.2024.130722_bb0020 article-title: The gustin gene variation at rs2274333 and PROP taster status affect dietary fat perception: a stepwise multiple regression model study publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2024.109619 – volume: 1511 year: 2022 ident: 10.1016/j.bbagen.2024.130722_bb0195 article-title: Bioactive lipids and metabolic syndrome—a symposium report publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.14752 – volume: 2 year: 2009 ident: 10.1016/j.bbagen.2024.130722_bb0170 article-title: CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior publication-title: Sci. Signal. doi: 10.1126/scisignal.272re3 – volume: 279 start-page: 40521 year: 2004 ident: 10.1016/j.bbagen.2024.130722_bb0225 article-title: Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels publication-title: J. Biol. Chem. doi: 10.1074/jbc.M405280200 – volume: 250 start-page: 20 year: 2013 ident: 10.1016/j.bbagen.2024.130722_bb0105 article-title: Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice publication-title: Neuroscience doi: 10.1016/j.neuroscience.2013.06.043 – volume: 93 year: 2011 ident: 10.1016/j.bbagen.2024.130722_bb0150 article-title: Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.110.007583 – volume: 8 start-page: 172 year: 2017 ident: 10.1016/j.bbagen.2024.130722_bb0095 article-title: Dietary fiber and prebiotics and the gastrointestinal microbiota publication-title: Gut Microbes doi: 10.1080/19490976.2017.1290756 – volume: 53 year: 2014 ident: 10.1016/j.bbagen.2024.130722_bb0180 article-title: Cell signaling mechanisms of oro-gustatory detection of dietary fat: advances and challenges publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2013.11.001 – volume: 15 start-page: 633 year: 2023 ident: 10.1016/j.bbagen.2024.130722_bb0045 article-title: Novel fat taste receptor agonists curtail progressive weight gain in obese male mice publication-title: Cell Mol. Gastroenterol. Hepatol. doi: 10.1016/j.jcmgh.2022.11.003 – volume: 71 year: 2018 ident: 10.1016/j.bbagen.2024.130722_bb0145 article-title: Metabolically healthy obesity, transition to metabolic syndrome, and cardiovascular risk publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2018.02.055 – volume: 226 year: 2019 ident: 10.1016/j.bbagen.2024.130722_bb0165 article-title: Fatty acid taste quality information via GPR120 in the anterior tongue of mice publication-title: Acta Physiol. doi: 10.1111/apha.13215 – volume: 117 year: 2008 ident: 10.1016/j.bbagen.2024.130722_bb0140 article-title: Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.739714 – volume: 99 year: 2014 ident: 10.1016/j.bbagen.2024.130722_bb0155 article-title: Obesity interferes with the orosensory detection of long-chain fatty acids in humans publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.113.077198 – volume: 599 start-page: 485 year: 2021 ident: 10.1016/j.bbagen.2024.130722_bb0130 article-title: Dietary palmitic acid promotes a prometastatic memory via Schwann cells publication-title: Nature doi: 10.1038/s41586-021-04075-0 – volume: 22 year: 2008 ident: 10.1016/j.bbagen.2024.130722_bb0160 article-title: The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse publication-title: FASEB J. doi: 10.1096/fj.07-8415com – volume: 159 start-page: 318 year: 2014 ident: 10.1016/j.bbagen.2024.130722_bb0065 article-title: Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects publication-title: Cell doi: 10.1016/j.cell.2014.09.035 – volume: 30 year: 2010 ident: 10.1016/j.bbagen.2024.130722_bb0060 article-title: Taste preference for fatty acids is mediated by GPR40 and GPR120 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0496-10.2010 – volume: 129 year: 2022 ident: 10.1016/j.bbagen.2024.130722_bb0185 article-title: Exploring foods as natural sources of FAHFAs—A review of occurrence, extraction, analytical techniques and emerging bioactive potential publication-title: Trends Food Sci. Technol. doi: 10.1016/j.tifs.2022.11.005 – volume: 121 start-page: 206 year: 2010 ident: 10.1016/j.bbagen.2024.130722_bb0090 article-title: Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis publication-title: Trans. Am. Clin. Climatol. Assoc. – volume: 50 start-page: 225 year: 2011 ident: 10.1016/j.bbagen.2024.130722_bb0040 article-title: Fatty acid detection during food consumption and digestion: associations with ingestive behavior and obesity publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2011.02.002 – volume: 1 year: 2022 ident: 10.1016/j.bbagen.2024.130722_bb0110 article-title: Analytical evaluation of fatty acid esters of hydroxy fatty acid quantity in fermented brown rice and rice bran (FRBA) publication-title: Food Chem. Adv. doi: 10.1016/j.focha.2022.100040 – volume: 146 year: 2014 ident: 10.1016/j.bbagen.2024.130722_bb0010 article-title: CD36- and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.01.006 – start-page: 1 year: 2024 ident: 10.1016/j.bbagen.2024.130722_bb0025 article-title: T1R2/T1R3 polymorphism affects sweet and fat perception: correlation between SNP and BMI in the context of obesity development publication-title: Hum. Genet. – volume: 61 start-page: 133 year: 2020 ident: 10.1016/j.bbagen.2024.130722_bb0055 article-title: Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice publication-title: J. Lipid Res. doi: 10.1194/jlr.RA119000142 – volume: 30 start-page: 3489 year: 2016 ident: 10.1016/j.bbagen.2024.130722_bb0015 article-title: ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans publication-title: FASEB J. doi: 10.1096/fj.201600422R – volume: 272 start-page: 29434 year: 1997 ident: 10.1016/j.bbagen.2024.130722_bb0230 article-title: The role of pp60c-src in the regulation of calcium entry via store-operated calcium channels publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.47.29434 – volume: 96 start-page: 151 year: 2015 ident: 10.1016/j.bbagen.2024.130722_bb0035 article-title: Taste of fat: a sixth taste modality? publication-title: Physiol. Rev. doi: 10.1152/physrev.00002.2015 – volume: 137 start-page: 78 year: 2017 ident: 10.1016/j.bbagen.2024.130722_bb0135 article-title: ERK1 and ERK2 activation modulates diet-induced obesity in mice publication-title: Biochimie doi: 10.1016/j.biochi.2017.03.004 – volume: 163 year: 2023 ident: 10.1016/j.bbagen.2024.130722_bb0005 article-title: Tongue papillae density and fat taster status- a cardinal role on sweet and bitter taste perception among Indian population publication-title: Food Res. Int. doi: 10.1016/j.foodres.2022.112294 – volume: 2 year: 2012 ident: 10.1016/j.bbagen.2024.130722_bb0085 article-title: Molecular basis for the regulation of angiogenesis by thrombospondin-1 and-2 publication-title: Cold Spring Harb. Perspect. Med. doi: 10.1101/cshperspect.a006627 – volume: 78 year: 2020 ident: 10.1016/j.bbagen.2024.130722_bb0030 article-title: Preference for dietary fat: from detection to disease publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2020.101032 – volume: 25 year: 2006 ident: 10.1016/j.bbagen.2024.130722_bb0205 article-title: Endocrine functions of bile acids publication-title: EMBO J. doi: 10.1038/sj.emboj.7601049 – volume: 14 year: 2023 ident: 10.1016/j.bbagen.2024.130722_bb0100 article-title: Immunomodulatory effects of inulin and its intestinal metabolites publication-title: Front. Immunol. doi: 10.3389/fimmu.2023.1224092 – volume: 53 year: 2010 ident: 10.1016/j.bbagen.2024.130722_bb0210 article-title: Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes publication-title: Diabetologia doi: 10.1007/s00125-010-1832-7 – volume: 8 start-page: 15757 year: 2018 ident: 10.1016/j.bbagen.2024.130722_bb0050 article-title: Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids publication-title: Sci. Rep. doi: 10.1038/s41598-018-34113-3 – volume: 291 start-page: 22207 year: 2016 ident: 10.1016/j.bbagen.2024.130722_bb0070 article-title: Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.703835 – year: 2021 ident: 10.1016/j.bbagen.2024.130722_bb0075 article-title: Single nucleotide polymorphism in CD36: correlation to peptide YY levels in obese and non-obese adults publication-title: Clin. Nutr. – volume: 62 year: 2021 ident: 10.1016/j.bbagen.2024.130722_bb0190 article-title: Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs) publication-title: J. Lipid Res. doi: 10.1016/j.jlr.2021.100108 |
| SSID | ssj0000595 |
| Score | 2.4476502 |
| Snippet | Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 130722 |
| SubjectTerms | Animals Calcium - metabolism Calcium Signaling CD36 CD36 Antigens - metabolism FAHFAs Fat GPR120 Male Mice Mice, Inbred C57BL Receptors, G-Protein-Coupled - metabolism src-Family Kinases - metabolism Taste - physiology Taste Buds - metabolism |
| Title | FAHFA promotes intracellular calcium signaling via activating the fat taste receptor, CD36 and Src protein kinases in mice taste bud cells |
| URI | https://dx.doi.org/10.1016/j.bbagen.2024.130722 https://www.ncbi.nlm.nih.gov/pubmed/39426759 https://www.proquest.com/docview/3118471332 |
| Volume | 1868 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhIbSXklfbPJlCjnHXtmSvfVw2WbYNzSUJ7E3oCW6Id8l6C73kB-RXZ8ayE3IIhZ6MjGQ9Rp75JH2jYezUp8ohyvdRqn0aoZakQO7eRok1iE5jXWaGHIV_XeXTW_Fzls3W2Lj3hSFaZaf7g05vtXX3ZtCN5mBRVYNrOtRDOJERCxIfM_JgF0Oa5d8fX2keCB-ycJIgIsrdu8-1HC-t8aelW1BTQWGRh2n6nnl6D362ZmiyxT51-BFGoYnbbM3VO2wzRJT8u8M-jPsAbrvsaTKaTkawaAl3bgkV7ePSRj0xTwFlY6rVPRCBQ5FPOvypFJCbA23SYhKRIXjVQKNwIgAOklvg-vwMxuc8B1VbuH4w0F7zUNVwV9VoDqkOoPj2XSG9skAVLvfY7eTiZjyNutALkeFJ0kRCe_xRDdoutOmG-zzWyheGx6VKhMWRson3Q1N4ZXKdmAIVR1Fa42LjVWJVyj-z9Xpeu68MlLO54r5IEGuKIvMlfiTWQgltPMdS-yzqR1wuwg0bsqee_ZZBQpIkJIOE9tmwF4t8M1MkGoF_lPzWS1GiKKj_qnbz1VJin8lKc455vgTxvrQFW53iqqo8-O96D9lHSgUSzBFbbx5W7hihTKNP2rl6wjZGPy6nV89TCvLq |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIlQuFZRXWx6DxJGwSexkk-NqYbVA20tbaW-Wn1JApKtuFokLP4Bf3Zk4AXGokDhFeTh-jD3z2f7GA_Am5NoTyg9JbkKekJbkQO7BJZmzhE5TUxeWHYVPz8rlpfy0KlY7MB99YZhWOej-qNN7bT08mQytOVk3zeScN_UIThTMgqTL6g7clTR8OYzBu59_eB6EH4q4lSAT_nz0n-tJXsbQqOVjUHPJcZGneX6bfboNf_Z2aPEA9gcAibNYxoew49sDuBdDSv44gL35GMHtEfxazJaLGa57xp3fYMMLubxSz9RTJOHYZvsNmcGh2Skdvzca2c-BV2nplqAhBt1hp6knILWSX9ME_S3O34sSdevw_Npif85D0-LXpiV7yHkgB7gfEpmtQ85w8xguFx8u5stkiL2QWJFlXSJNoJFqyXiRUbcilKnRobIirXUmHbWUy0KY2ipoW5rMVqQ5qtpZn9qgM6dz8QR226vWPwPU3pVahCojsCmrItT0k9RILY0NglIdQjK2uFrHIzbUyD37oqKEFEtIRQkdwnQUi_qrqyiyAv9I-XqUoiJRcP1166-2G0V1ZjMtBH3zNIr3d1mo1DlNq-qj_873FewtL05P1MnHs8_HcJ_fREbMc9jtrrf-BeGazrzs--0N4gX0eA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=FAHFA+promotes+intracellular+calcium+signaling+via+activating+the+fat+taste+receptor%2C+CD36+and+Src+protein+kinases+in+mice+taste+bud+cells&rft.jtitle=Biochimica+et+biophysica+acta.+General+subjects&rft.au=Muthuswamy%2C+Karthi&rft.au=Vasanthakumar%2C+Keerthana&rft.au=Panneerselvan%2C+Prabha&rft.au=Thangamani%2C+Lokesh&rft.date=2024-12-01&rft.pub=Elsevier+B.V&rft.issn=0304-4165&rft.volume=1868&rft.issue=12&rft_id=info:doi/10.1016%2Fj.bbagen.2024.130722&rft.externalDocID=S030441652400165X |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |