A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA

• Published in: Clinical cancer research Vol. 31; no. 9; pp. 1605 - 1614
• Main Authors: Rettig, Eleni M., Schoenfeld, Jonathan D., Miller, Julianna, Sargent, Bethany, Carey, Evan, Margalit, Danielle N., Sehgal, Kartik, Sethi, Rosh K.V., Uppaluri, Ravindra, Tishler, Roy B., Goguen, Laura A., Annino, Donald J., Sim, Edward S., Jo, Vickie Y., Wong, Kristine S., Guenette, Jeffrey P., Haddad, Robert I., Hanna, Glenn J.
• Format: Journal Article
• Language: English
• Published: United States 01.05.2025
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; DNA, Viral - blood; DNA, Viral - genetics; Early Detection of Cancer - methods; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local - blood; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - virology; Oropharyngeal Neoplasms - blood; Oropharyngeal Neoplasms - diagnosis; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - virology; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - blood; Papillomavirus Infections - complications; Papillomavirus Infections - diagnosis; Papillomavirus Infections - virology; Prospective Studies

Observational studies suggest circulating tumor human papillomavirus (HPV) DNA may facilitate early detection of recurrent HPV-positive oropharynx cancer. We prospectively investigated whether biomarker-guided surveillance detects recurrence earlier than the standard-of-care methods. We enrolled pat...