Long-term effects of streptozotocin-induced gestational diabetes mellitus on mechanical sensitivity and intraepidermal nerve fibers in female and male mice offspring
•The mechanical sensitivity and intraepidermal density were assessed in middle-aged offspring of dams with GDM.•Middle-aged offspring had greater mechanical sensitivity and lower intraepidermal CGRP+ and PGP9.5+ density.•GDM effects on middle-aged offspring are sex independent. While the long-term c...
Saved in:
Published in | Neuroscience letters Vol. 812; p. 137402 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
24.08.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | •The mechanical sensitivity and intraepidermal density were assessed in middle-aged offspring of dams with GDM.•Middle-aged offspring had greater mechanical sensitivity and lower intraepidermal CGRP+ and PGP9.5+ density.•GDM effects on middle-aged offspring are sex independent.
While the long-term complications of gestational diabetes mellitus (GDM) in the cardiovascular, endocrine, and central nervous systems from offspring have been widely studied, less is known about the long-term outcomes of GDM on the peripheral nervous system. Thus, here we assessed the mechanical sensitivity and density of nerve fibers of the hind paw from middle-aged offspring born from dams with GDM. GDM was induced by the intraperitoneal administration of streptozotocin (STZ) in mouse dams. Mechanical sensitivity in male and female offspring was bi-weekly evaluated from week 18 to week 40 of age. At 40 weeks old, offspring were sacrificed and glabrous hind paw skin was processed for immunohistochemistry to determine the density of intraepidermal CGRP and PGP9.5 positive nerve fibers. Offspring mice born from STZ-treated dams had significantly greater mechanical sensitivity from 18 to 40 weeks of age compared to offspring born from vehicle-treated dams (control group). The density of intraepidermal CGRP+ and PGP9.5+ nerve fibers were significantly lower in the hind paw skin of female but not male offspring, born from STZ-treated dams versus the control group. These results suggest that GDM has long-term sex-dependent complications on the nociceptive system. Further studies are necessary to elucidate the mechanisms underlying the GDM-induced long-term consequences. |
---|---|
AbstractList | While the long-term complications of gestational diabetes mellitus (GDM) in the cardiovascular, endocrine, and central nervous systems from offspring have been widely studied, less is known about the long-term outcomes of GDM on the peripheral nervous system. Thus, here we assessed the mechanical sensitivity and density of nerve fibers of the hind paw from middle-aged offspring born from dams with GDM. GDM was induced by the intraperitoneal administration of streptozotocin (STZ) in mouse dams. Mechanical sensitivity in male and female offspring was bi-weekly evaluated from week 18 to week 40 of age. At 40 weeks old, offspring were sacrificed and glabrous hind paw skin was processed for immunohistochemistry to determine the density of intraepidermal CGRP and PGP9.5 positive nerve fibers. Offspring mice born from STZ-treated dams had significantly greater mechanical sensitivity from 18 to 40 weeks of age compared to offspring born from vehicle-treated dams (control group). The density of intraepidermal CGRP
and PGP9.5
nerve fibers were significantly lower in the hind paw skin of female but not male offspring, born from STZ-treated dams versus the control group. These results suggest that GDM has long-term sex-dependent complications on the nociceptive system. Further studies are necessary to elucidate the mechanisms underlying the GDM-induced long-term consequences. •The mechanical sensitivity and intraepidermal density were assessed in middle-aged offspring of dams with GDM.•Middle-aged offspring had greater mechanical sensitivity and lower intraepidermal CGRP+ and PGP9.5+ density.•GDM effects on middle-aged offspring are sex independent. While the long-term complications of gestational diabetes mellitus (GDM) in the cardiovascular, endocrine, and central nervous systems from offspring have been widely studied, less is known about the long-term outcomes of GDM on the peripheral nervous system. Thus, here we assessed the mechanical sensitivity and density of nerve fibers of the hind paw from middle-aged offspring born from dams with GDM. GDM was induced by the intraperitoneal administration of streptozotocin (STZ) in mouse dams. Mechanical sensitivity in male and female offspring was bi-weekly evaluated from week 18 to week 40 of age. At 40 weeks old, offspring were sacrificed and glabrous hind paw skin was processed for immunohistochemistry to determine the density of intraepidermal CGRP and PGP9.5 positive nerve fibers. Offspring mice born from STZ-treated dams had significantly greater mechanical sensitivity from 18 to 40 weeks of age compared to offspring born from vehicle-treated dams (control group). The density of intraepidermal CGRP+ and PGP9.5+ nerve fibers were significantly lower in the hind paw skin of female but not male offspring, born from STZ-treated dams versus the control group. These results suggest that GDM has long-term sex-dependent complications on the nociceptive system. Further studies are necessary to elucidate the mechanisms underlying the GDM-induced long-term consequences. |
ArticleNumber | 137402 |
Author | Hernandez, Ivanna Acosta-González, Rosa Issel Muñoz-Islas, Enriqueta Jiménez-Andrade, Juan Miguel Vazquez-Mora, Juan Antonio Vargas-Balderas, Dehni Irasema |
Author_xml | – sequence: 1 givenname: Enriqueta orcidid: 0000-0003-4609-9328 surname: Muñoz-Islas fullname: Muñoz-Islas, Enriqueta email: e.munoz.islas@gmail.com – sequence: 2 givenname: Dehni Irasema surname: Vargas-Balderas fullname: Vargas-Balderas, Dehni Irasema – sequence: 3 givenname: Ivanna surname: Hernandez fullname: Hernandez, Ivanna – sequence: 4 givenname: Juan Antonio surname: Vazquez-Mora fullname: Vazquez-Mora, Juan Antonio – sequence: 5 givenname: Rosa Issel surname: Acosta-González fullname: Acosta-González, Rosa Issel – sequence: 6 givenname: Juan Miguel surname: Jiménez-Andrade fullname: Jiménez-Andrade, Juan Miguel |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37507046$$D View this record in MEDLINE/PubMed |
BookMark | eNp9UU1v1DAUtFAR3Rb-AUI-csliJ944uSChqkCllbjA2fLH8_JWib3Yzkrt_-F_4jaFIyc_eWY8bzxX5CLEAIS85WzLGe8_HLcBlgnKtmVtt-WdFKx9QTZ8kG0jR9lekA3rmGi6UbBLcpXzkTG24zvxilx2csckE_2G_N7HcGgKpJmC92BLptHTXBKcSnyIJVoMDQa3WHD0ALnogjHoiTrUBgpkOsM0YVmqLtTZ_tQBbcUzhIwFz1juqQ6OYihJwwldtapwgHQG6tFAyhWjHuotPDGfhhkt1E18PiUMh9fkpddThjfP5zX58fn2-83XZv_ty93Np31jO85LI0bDhrEdRmOZA-EN81rLfuS6H7TjFgZtxE46N8rOOO-dtVa7wdt-6I0Usrsm79d3Tyn-WmpaNWO2NaAOEJes2kGIXspBskoVK9WmmHMCr-qms073ijP1WJA6qrUg9ViQWguqsnfPDouZwf0T_W2kEj6uBKg5zwhJZYsQ6vdjqvUoF_H_Dn8AXYqrfQ |
Cites_doi | 10.1016/0165-0270(94)90144-9 10.2337/db12-0289 10.1001/jama.2018.11628 10.2337/dc22-S015 10.1007/s00508-018-1419-8 10.2337/db10-0979 10.1007/s00592-018-1176-1 10.1016/j.diabres.2018.09.003 10.1146/annurev.pa.20.040180.002301 10.1371/journal.pone.0195531 10.1016/j.pedneo.2020.12.012 10.1097/AOG.0b013e31823974e2 10.1111/ejn.13771 10.1007/s40618-016-0607-5 10.1016/0304-3959(83)90201-4 10.1080/14767058.2017.1387893 10.1093/ije/dyx151 10.2147/JPR.S313467 10.4161/epi.25578 10.1371/journal.pone.0031821 10.1002/jdn.10023 10.1371/journal.pone.0058243 10.1177/153537020322800204 10.1002/(SICI)1097-4547(19990815)57:4<521::AID-JNR11>3.0.CO;2-B 10.2337/dc17-0514 10.1542/peds.2008-0158 |
ContentType | Journal Article |
Copyright | 2023 Elsevier B.V. Copyright © 2023 Elsevier B.V. All rights reserved. |
Copyright_xml | – notice: 2023 Elsevier B.V. – notice: Copyright © 2023 Elsevier B.V. All rights reserved. |
DBID | NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.neulet.2023.137402 |
DatabaseName | PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1872-7972 |
EndPage | 137402 |
ExternalDocumentID | 10_1016_j_neulet_2023_137402 37507046 S0304394023003610 |
Genre | Journal Article |
GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AIEXJ AIKHN AITUG AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSN SSZ T5K WH7 YCJ ~G- 53G AAEDT AAQFI AAXKI AFJKZ AKRWK NPM RIG .55 .GJ 29N 5VS AAQXK AAYXX ABTAH ABXDB ADIYS ADMUD AHHHB ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HMQ HVGLF HZ~ MVM R2- SNS WUQ X7M ZGI ZXP ZY4 7X8 |
ID | FETCH-LOGICAL-c311t-49b089289bc0de4fb0faa7691a68ad1ce8ab457dd973bdffdcccad8fc686b7473 |
IEDL.DBID | AIKHN |
ISSN | 0304-3940 |
IngestDate | Sat Oct 05 04:56:52 EDT 2024 Thu Sep 26 15:41:26 EDT 2024 Sat Sep 28 08:17:37 EDT 2024 Fri Feb 23 02:35:48 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Long-term outcomes GDM Nerve fibers Offspring Mechanical sensitivity |
Language | English |
License | Copyright © 2023 Elsevier B.V. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c311t-49b089289bc0de4fb0faa7691a68ad1ce8ab457dd973bdffdcccad8fc686b7473 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-4609-9328 |
PMID | 37507046 |
PQID | 2844677870 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | proquest_miscellaneous_2844677870 crossref_primary_10_1016_j_neulet_2023_137402 pubmed_primary_37507046 elsevier_sciencedirect_doi_10_1016_j_neulet_2023_137402 |
PublicationCentury | 2000 |
PublicationDate | 2023-08-24 |
PublicationDateYYYYMMDD | 2023-08-24 |
PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-24 day: 24 |
PublicationDecade | 2020 |
PublicationPlace | Ireland |
PublicationPlace_xml | – name: Ireland |
PublicationTitle | Neuroscience letters |
PublicationTitleAlternate | Neurosci Lett |
PublicationYear | 2023 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | Landon, Gabbe (b0030) 2011; 118 Kinney, Rabe, Jensen, Steger (b0075) 2003; 228 Germani, Lesma, Di Giulio, Gorio (b0125) 1999; 57 Su, Liu, Chen, Ou-Yang, Huang, Tsai, Chen (b0070) 2021; 62 Munoz-Islas, Elizondo-Martinez, Gutierrez-Lopez, Acosta-Gonzalez, Zaga-Clavellina, Helguera-Repetto, Ramirez-Rosas, Romero-Sandoval, Jimenez-Andrade (b0045) 2021; 14 Burlina, Dalfrà, Lapolla (b0020) 2019; 32 Campos Lima, Lemes, Capop, de Lima, Monteiro da Cruz Lotufo (b0040) 2020; 80 Chiefari, Arcidiacono, Foti, Brunetti (b0010) 2017; 40 A.D.A.P.P. Committee, 15. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2022, Diabetes Care 45 (2021) S232-S243. Grunnet, Hansen, Hjort, Madsen, Kampmann, Thuesen, Granstrømi, Strøm, Maslova, Frikke-Schmidt, Damm, Chavarro, Hu, Olsen, Vaag (b0065) 2017; 40 Valdés Ramos, Blanco Rojas (b0035) 2011; 37 Relton, Groom, St. Pourcain, Sayers, Swan, Embleton, Pearce, Ring, Northstone, Tobias, Trakalo, Ness, Shaheen, Davey Smith, Uddin (b0120) 2012; 7 Abokaf, Shoham-Vardi, Sergienko, Landau, Sheiner (b0060) 2018; 144 Hokke, Armitage, Puelles, Short, Jones, Smyth, Bertram, Cullen-McEwen, Ashton (b0085) 2013; 8 Pham, Tu, Katano, Matsumura, Saito, Yamada, Furue, Ito (b0100) 2018; 47 Dixon (b0095) 1980; 20 Zimmermann (b0080) 1983; 16 El Hajj, Pliushch, Schneider, Dittrich, Müller, Korenkov, Aretz, Zechner, Lehnen, Haaf (b0110) 2013; 62 Godfrey, Sheppard, Gluckman, Lillycrop, Burdge, McLean, Rodford, Slater-Jefferies, Garratt, Crozier, Emerald, Gale, Inskip, Cooper, Hanson (b0115) 2011; 60 Leybovitz-Haleluya, Wainstock, Landau, Sheiner (b0050) 2018; 55 Kautzky-Willer, Harreiter, Winhofer-Stöckl, Bancher-Todesca, Berger, Repa, Lechleitner, Weitgasser (b0015) 2019; 131 Lowe, Scholtens, Lowe, Kuang, Nodzenski, Talbot, Catalano, Linder, Brickman, Clayton, Deerochanawong, Hamilton, Josefson, Lashley, Lawrence, Lebenthal, Ma, Maresh, McCance, Tam, Sacks, Dyer, Metzger (b0025) 2018; 320 Yu, Arah, Liew, Cnattingius, Olsen, Sørensen, Qin, Li (b0055) 2019; 367 Chaplan, Bach, Pogrel, Chung, Yaksh (b0090) 1994; 53 Tam, Ma, Yang, Ko, Tong, Cockram, Sahota, Rogers, Chan (b0130) 2008; 122 Li, Zhu, Yeung, Chavarro, Yuan, Field, Missmer, Mills, Hu, Zhang (b0140) 2017; 46 Ruchat, Houde, Voisin, St-Pierre, Perron, Baillargeon, Gaudet, Hivert, Brisson, Bouchard (b0105) 2013; 8 Le Moullec, Fianu, Maillard, Chazelle, Naty, Schneebeli, Gérardin, Huiart, Charles, Favier, Luo (b0135) 2018; 13 Germani (10.1016/j.neulet.2023.137402_b0125) 1999; 57 Lowe (10.1016/j.neulet.2023.137402_b0025) 2018; 320 Burlina (10.1016/j.neulet.2023.137402_b0020) 2019; 32 Valdés Ramos (10.1016/j.neulet.2023.137402_b0035) 2011; 37 Tam (10.1016/j.neulet.2023.137402_b0130) 2008; 122 Godfrey (10.1016/j.neulet.2023.137402_b0115) 2011; 60 Yu (10.1016/j.neulet.2023.137402_b0055) 2019; 367 Chaplan (10.1016/j.neulet.2023.137402_b0090) 1994; 53 Dixon (10.1016/j.neulet.2023.137402_b0095) 1980; 20 Kinney (10.1016/j.neulet.2023.137402_b0075) 2003; 228 Abokaf (10.1016/j.neulet.2023.137402_b0060) 2018; 144 Munoz-Islas (10.1016/j.neulet.2023.137402_b0045) 2021; 14 Pham (10.1016/j.neulet.2023.137402_b0100) 2018; 47 Ruchat (10.1016/j.neulet.2023.137402_b0105) 2013; 8 Landon (10.1016/j.neulet.2023.137402_b0030) 2011; 118 El Hajj (10.1016/j.neulet.2023.137402_b0110) 2013; 62 Hokke (10.1016/j.neulet.2023.137402_b0085) 2013; 8 Campos Lima (10.1016/j.neulet.2023.137402_b0040) 2020; 80 Li (10.1016/j.neulet.2023.137402_b0140) 2017; 46 Leybovitz-Haleluya (10.1016/j.neulet.2023.137402_b0050) 2018; 55 Zimmermann (10.1016/j.neulet.2023.137402_b0080) 1983; 16 Le Moullec (10.1016/j.neulet.2023.137402_b0135) 2018; 13 Chiefari (10.1016/j.neulet.2023.137402_b0010) 2017; 40 Kautzky-Willer (10.1016/j.neulet.2023.137402_b0015) 2019; 131 Relton (10.1016/j.neulet.2023.137402_b0120) 2012; 7 Grunnet (10.1016/j.neulet.2023.137402_b0065) 2017; 40 10.1016/j.neulet.2023.137402_b0005 Su (10.1016/j.neulet.2023.137402_b0070) 2021; 62 |
References_xml | – volume: 55 start-page: 1037 year: 2018 end-page: 1042 ident: b0050 article-title: Maternal gestational diabetes mellitus and the risk of subsequent pediatric cardiovascular diseases of the offspring: a population-based cohort study with up to 18 years of follow up publication-title: Acta Diabetol. contributor: fullname: Sheiner – volume: 13 start-page: e0195531 year: 2018 ident: b0135 article-title: Sexual dimorphism in the association between gestational diabetes mellitus and overweight in offspring at 5–7 years: the OBEGEST cohort study publication-title: PLoS One contributor: fullname: Luo – volume: 32 start-page: 687 year: 2019 end-page: 694 ident: b0020 article-title: Short- and long-term consequences for offspring exposed to maternal diabetes: a review publication-title: J. Matern. Fetal Neonatal Med. contributor: fullname: Lapolla – volume: 46 start-page: 1533 year: 2017 end-page: 1541 ident: b0140 article-title: Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association publication-title: Int. J. Epidemiol. contributor: fullname: Zhang – volume: 62 start-page: 298 year: 2021 end-page: 304 ident: b0070 article-title: Correlations between serum BDNF levels and neurodevelopmental outcomes in infants of mothers with gestational diabetes publication-title: Pediatr. Neonatol. contributor: fullname: Chen – volume: 40 start-page: 1746 year: 2017 end-page: 1755 ident: b0065 article-title: Adiposity, dysmetabolic traits, and earlier onset of female puberty in adolescent offspring of women with gestational diabetes mellitus: a clinical study within the danish national birth cohort publication-title: Diabetes Care contributor: fullname: Vaag – volume: 80 start-page: 267 year: 2020 end-page: 275 ident: b0040 article-title: Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats publication-title: Int. J. Dev. Neurosci. contributor: fullname: Monteiro da Cruz Lotufo – volume: 60 start-page: 1528 year: 2011 end-page: 1534 ident: b0115 article-title: Epigenetic gene promoter methylation at birth is associated with child's later adiposity publication-title: Diabetes contributor: fullname: Hanson – volume: 53 start-page: 55 year: 1994 end-page: 63 ident: b0090 article-title: Quantitative assessment of tactile allodynia in the rat paw publication-title: J. Neurosci. Methods contributor: fullname: Yaksh – volume: 8 start-page: 935 year: 2013 end-page: 943 ident: b0105 article-title: Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases publication-title: Epigenetics contributor: fullname: Bouchard – volume: 37 start-page: 502 year: 2011 end-page: 512 ident: b0035 article-title: Frecuencia y factores de riesgo asociados con la aparición de Diabetes Mellitus Gestacional, Revista Cubana de Obstetricia y publication-title: Ginecologia contributor: fullname: Blanco Rojas – volume: 16 start-page: 109 year: 1983 end-page: 110 ident: b0080 article-title: Ethical guidelines for investigations of experimental pain in conscious animals publication-title: Pain contributor: fullname: Zimmermann – volume: 8 start-page: e58243 year: 2013 ident: b0085 article-title: Altered ureteric branching morphogenesis and nephron endowment in offspring of diabetic and insulin-treated pregnancy publication-title: PLoS One contributor: fullname: Ashton – volume: 131 start-page: 91 year: 2019 end-page: 102 ident: b0015 article-title: Gestational diabetes mellitus (Update 2019) publication-title: Wien. Klin. Wochenschr. contributor: fullname: Weitgasser – volume: 118 start-page: 1379 year: 2011 end-page: 1393 ident: b0030 article-title: Gestational diabetes mellitus publication-title: Obstet. Gynecol. contributor: fullname: Gabbe – volume: 367 year: 2019 ident: b0055 article-title: Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up publication-title: BMJ contributor: fullname: Li – volume: 7 start-page: e31821 year: 2012 ident: b0120 article-title: DNA methylation patterns in cord blood DNA and body size in childhood publication-title: PLoS One contributor: fullname: Uddin – volume: 40 start-page: 899 year: 2017 end-page: 909 ident: b0010 article-title: Gestational diabetes mellitus: an updated overview publication-title: J. Endocrinol. Invest. contributor: fullname: Brunetti – volume: 320 start-page: 1005 year: 2018 ident: b0025 article-title: Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity publication-title: J. Am. Med. Assoc. contributor: fullname: Metzger – volume: 20 start-page: 441 year: 1980 end-page: 462 ident: b0095 article-title: Efficient analysis of experimental observations publication-title: Annu. Rev. Pharmacol. Toxicol. contributor: fullname: Dixon – volume: 228 start-page: 152 year: 2003 end-page: 159 ident: b0075 article-title: Maternal hyperglycemia leads to gender-dependent deficits in learning and memory in offspring publication-title: Exp. Biol. Med. (Maywood) contributor: fullname: Steger – volume: 144 start-page: 231 year: 2018 end-page: 235 ident: b0060 article-title: In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring publication-title: Diabetes Res. Clin. Pract. contributor: fullname: Sheiner – volume: 47 start-page: 126 year: 2018 end-page: 139 ident: b0100 article-title: Impaired peripheral nerve regeneration in type-2 diabetic mouse model publication-title: Eur. J. Neurosci. contributor: fullname: Ito – volume: 57 start-page: 521 year: 1999 end-page: 528 ident: b0125 article-title: Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by perinatal diabetes: protective action of antioxidant treatment publication-title: J. Neurosci. Res. contributor: fullname: Gorio – volume: 122 start-page: 1229 year: 2008 end-page: 1234 ident: b0130 article-title: Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero publication-title: Pediatrics contributor: fullname: Chan – volume: 14 start-page: 1573 year: 2021 end-page: 1585 ident: b0045 article-title: Effect of experimental gestational diabetes mellitus on mechanical sensitivity. capsaicin-induced pain behaviors and hind paw glabrous skin innervation of male and female mouse offspring publication-title: J. Pain Res. contributor: fullname: Jimenez-Andrade – volume: 62 start-page: 1320 year: 2013 end-page: 1328 ident: b0110 article-title: Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus publication-title: Diabetes contributor: fullname: Haaf – volume: 53 start-page: 55 issue: 1 year: 1994 ident: 10.1016/j.neulet.2023.137402_b0090 article-title: Quantitative assessment of tactile allodynia in the rat paw publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(94)90144-9 contributor: fullname: Chaplan – volume: 62 start-page: 1320 year: 2013 ident: 10.1016/j.neulet.2023.137402_b0110 article-title: Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus publication-title: Diabetes doi: 10.2337/db12-0289 contributor: fullname: El Hajj – volume: 320 start-page: 1005 issue: 10 year: 2018 ident: 10.1016/j.neulet.2023.137402_b0025 article-title: Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2018.11628 contributor: fullname: Lowe – ident: 10.1016/j.neulet.2023.137402_b0005 doi: 10.2337/dc22-S015 – volume: 131 start-page: 91 year: 2019 ident: 10.1016/j.neulet.2023.137402_b0015 article-title: Gestational diabetes mellitus (Update 2019) publication-title: Wien. Klin. Wochenschr. doi: 10.1007/s00508-018-1419-8 contributor: fullname: Kautzky-Willer – volume: 60 start-page: 1528 year: 2011 ident: 10.1016/j.neulet.2023.137402_b0115 article-title: Epigenetic gene promoter methylation at birth is associated with child's later adiposity publication-title: Diabetes doi: 10.2337/db10-0979 contributor: fullname: Godfrey – volume: 55 start-page: 1037 year: 2018 ident: 10.1016/j.neulet.2023.137402_b0050 article-title: Maternal gestational diabetes mellitus and the risk of subsequent pediatric cardiovascular diseases of the offspring: a population-based cohort study with up to 18 years of follow up publication-title: Acta Diabetol. doi: 10.1007/s00592-018-1176-1 contributor: fullname: Leybovitz-Haleluya – volume: 144 start-page: 231 year: 2018 ident: 10.1016/j.neulet.2023.137402_b0060 article-title: In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2018.09.003 contributor: fullname: Abokaf – volume: 20 start-page: 441 issue: 1 year: 1980 ident: 10.1016/j.neulet.2023.137402_b0095 article-title: Efficient analysis of experimental observations publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev.pa.20.040180.002301 contributor: fullname: Dixon – volume: 13 start-page: e0195531 issue: 4 year: 2018 ident: 10.1016/j.neulet.2023.137402_b0135 article-title: Sexual dimorphism in the association between gestational diabetes mellitus and overweight in offspring at 5–7 years: the OBEGEST cohort study publication-title: PLoS One doi: 10.1371/journal.pone.0195531 contributor: fullname: Le Moullec – volume: 367 year: 2019 ident: 10.1016/j.neulet.2023.137402_b0055 article-title: Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up publication-title: BMJ contributor: fullname: Yu – volume: 62 start-page: 298 issue: 3 year: 2021 ident: 10.1016/j.neulet.2023.137402_b0070 article-title: Correlations between serum BDNF levels and neurodevelopmental outcomes in infants of mothers with gestational diabetes publication-title: Pediatr. Neonatol. doi: 10.1016/j.pedneo.2020.12.012 contributor: fullname: Su – volume: 118 start-page: 1379 year: 2011 ident: 10.1016/j.neulet.2023.137402_b0030 article-title: Gestational diabetes mellitus publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0b013e31823974e2 contributor: fullname: Landon – volume: 47 start-page: 126 issue: 2 year: 2018 ident: 10.1016/j.neulet.2023.137402_b0100 article-title: Impaired peripheral nerve regeneration in type-2 diabetic mouse model publication-title: Eur. J. Neurosci. doi: 10.1111/ejn.13771 contributor: fullname: Pham – volume: 40 start-page: 899 issue: 9 year: 2017 ident: 10.1016/j.neulet.2023.137402_b0010 article-title: Gestational diabetes mellitus: an updated overview publication-title: J. Endocrinol. Invest. doi: 10.1007/s40618-016-0607-5 contributor: fullname: Chiefari – volume: 16 start-page: 109 issue: 2 year: 1983 ident: 10.1016/j.neulet.2023.137402_b0080 article-title: Ethical guidelines for investigations of experimental pain in conscious animals publication-title: Pain doi: 10.1016/0304-3959(83)90201-4 contributor: fullname: Zimmermann – volume: 32 start-page: 687 issue: 4 year: 2019 ident: 10.1016/j.neulet.2023.137402_b0020 article-title: Short- and long-term consequences for offspring exposed to maternal diabetes: a review publication-title: J. Matern. Fetal Neonatal Med. doi: 10.1080/14767058.2017.1387893 contributor: fullname: Burlina – volume: 46 start-page: 1533 year: 2017 ident: 10.1016/j.neulet.2023.137402_b0140 article-title: Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyx151 contributor: fullname: Li – volume: 37 start-page: 502 year: 2011 ident: 10.1016/j.neulet.2023.137402_b0035 article-title: Frecuencia y factores de riesgo asociados con la aparición de Diabetes Mellitus Gestacional, Revista Cubana de Obstetricia y publication-title: Ginecologia contributor: fullname: Valdés Ramos – volume: 14 start-page: 1573 year: 2021 ident: 10.1016/j.neulet.2023.137402_b0045 article-title: Effect of experimental gestational diabetes mellitus on mechanical sensitivity. capsaicin-induced pain behaviors and hind paw glabrous skin innervation of male and female mouse offspring publication-title: J. Pain Res. doi: 10.2147/JPR.S313467 contributor: fullname: Munoz-Islas – volume: 8 start-page: 935 issue: 9 year: 2013 ident: 10.1016/j.neulet.2023.137402_b0105 article-title: Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases publication-title: Epigenetics doi: 10.4161/epi.25578 contributor: fullname: Ruchat – volume: 7 start-page: e31821 issue: 3 year: 2012 ident: 10.1016/j.neulet.2023.137402_b0120 article-title: DNA methylation patterns in cord blood DNA and body size in childhood publication-title: PLoS One doi: 10.1371/journal.pone.0031821 contributor: fullname: Relton – volume: 80 start-page: 267 year: 2020 ident: 10.1016/j.neulet.2023.137402_b0040 article-title: Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats publication-title: Int. J. Dev. Neurosci. doi: 10.1002/jdn.10023 contributor: fullname: Campos Lima – volume: 8 start-page: e58243 issue: 3 year: 2013 ident: 10.1016/j.neulet.2023.137402_b0085 article-title: Altered ureteric branching morphogenesis and nephron endowment in offspring of diabetic and insulin-treated pregnancy publication-title: PLoS One doi: 10.1371/journal.pone.0058243 contributor: fullname: Hokke – volume: 228 start-page: 152 issue: 2 year: 2003 ident: 10.1016/j.neulet.2023.137402_b0075 article-title: Maternal hyperglycemia leads to gender-dependent deficits in learning and memory in offspring publication-title: Exp. Biol. Med. (Maywood) doi: 10.1177/153537020322800204 contributor: fullname: Kinney – volume: 57 start-page: 521 year: 1999 ident: 10.1016/j.neulet.2023.137402_b0125 article-title: Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by perinatal diabetes: protective action of antioxidant treatment publication-title: J. Neurosci. Res. doi: 10.1002/(SICI)1097-4547(19990815)57:4<521::AID-JNR11>3.0.CO;2-B contributor: fullname: Germani – volume: 40 start-page: 1746 year: 2017 ident: 10.1016/j.neulet.2023.137402_b0065 article-title: Adiposity, dysmetabolic traits, and earlier onset of female puberty in adolescent offspring of women with gestational diabetes mellitus: a clinical study within the danish national birth cohort publication-title: Diabetes Care doi: 10.2337/dc17-0514 contributor: fullname: Grunnet – volume: 122 start-page: 1229 year: 2008 ident: 10.1016/j.neulet.2023.137402_b0130 article-title: Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero publication-title: Pediatrics doi: 10.1542/peds.2008-0158 contributor: fullname: Tam |
SSID | ssj0005154 |
Score | 2.452423 |
Snippet | •The mechanical sensitivity and intraepidermal density were assessed in middle-aged offspring of dams with GDM.•Middle-aged offspring had greater mechanical... While the long-term complications of gestational diabetes mellitus (GDM) in the cardiovascular, endocrine, and central nervous systems from offspring have been... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 137402 |
SubjectTerms | GDM Long-term outcomes Mechanical sensitivity Nerve fibers Offspring |
Title | Long-term effects of streptozotocin-induced gestational diabetes mellitus on mechanical sensitivity and intraepidermal nerve fibers in female and male mice offspring |
URI | https://dx.doi.org/10.1016/j.neulet.2023.137402 https://www.ncbi.nlm.nih.gov/pubmed/37507046 https://search.proquest.com/docview/2844677870 |
Volume | 812 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JaxRBFH7ECYgXiYnLaAwliLea6UpXb8chJIxLctFAbk2tMuJUD07PQQ_-G_-n73VVKwFF8NZb0UV_1W_9Xj2Al8pL44TOuECPlssiN1zrpuG1zlyjvckzR8XJl1fl8lq-uSlu9uBsrIUhWmWS_VGmD9I6XZmnrznfrFbz95TUo77eaESjGKYyq31UR1JOYH_x-u3y6jfTQxRxFylKAuCAsYJuoHkFt8MPNKMu4jORVzLFV_6gof5mgQ6a6OIA7icTki3iLB_AnguHcLQI6D6vv7JXbCB1DtHyQ7h7mXLnR_DjXRc-cpLELJE4WOcZ1Yps-u5b1yNKgaOHjlhbRlmnFCZkY3iWrWnzzn6H4wIeU8kwIcy2xIGPTSiYCpatKF7sqPMsCv3PLBCnknlipmzxHvMOr7rhyeFgjaIKZ-JjhvghXF-cfzhb8tSkgZtciJ7LRmd1g26bNpl10uvMK1WVjVBlrawwrlZaFpW1TZVr6701uGZs7U1Zlxp9mfwRTEIX3BNghbS1qozzKIWlc16dNqW26KF6lQsv6inwEZh2E_fiaEeS2qc2AtkSkG0EcgrViF57a021qC7-MfLFCHaLvxvlUFRw3W7bojaXtOdelU3hcVwFv-aSo_VVZbJ8-t_vfQb36Ixi1qfyGCb9l517jkZPr0_gzuy7OElL-yerkgcD |
link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELaqVAIuqLQ8AgWMhLi5WXe9r2NUtUppkgut1JvlJ0pFvBHZHOD_8D-ZWXuLkEBI3Fb2Wmv5847n8Y2HkPfKC-O4zhgHi5aJIjdM66Zhtc5co73JM4fJyYtlObsRH2-L2z1yNuTCIK0yyf4o03tpnVomaTUnm9Vq8gmDeljXG5RoEMOYZrUvioqLEdmfXl7Nlr-YHryIt0hhEAAGDBl0Pc0ruB0s0AlWET_heSWSf-UPJ9TfNND-JLo4II-TCkmncZZPyJ4Lh-RoGsB8Xn-jH2hP6uy95YfkwSLFzo_Ij3kbPjOUxDSROGjrKeaKbLr2e9sBSoGBhQ5YW4pRp-QmpIN7lq7x8s5uB-MCPGPKMCJMt8iBj0UoqAqWrtBf7LDyLAj9LzQgp5J6ZKZsoY96B62uf7N_WIOogpn4GCF-Sm4uzq_PZiwVaWAm57xjotFZ3YDZpk1mnfA680pVZcNVWSvLjauVBlisbapcW--tgT1ja2_KutRgy-TPyCi0wb0gtBC2VpVxHqSwcM6r06bUFixUr3LueT0mbABGbuJdHHIgqd3JCKREIGUEckyqAT35256ScFz8Y-S7AWwJvxvGUFRw7W4r4TQXeOdelY3J87gL7ueSg_ZVZaJ8-d_ffUsezq4Xczm_XF69Io-wB_3Xp-KYjLqvO_caFKBOv0kb_Cf_ywj1 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long-term+effects+of+streptozotocin-induced+gestational+diabetes+mellitus+on+mechanical+sensitivity+and+intraepidermal+nerve+fibers+in+female+and+male+mice+offspring&rft.jtitle=Neuroscience+letters&rft.au=Mu%C3%B1oz-Islas%2C+Enriqueta&rft.au=Vargas-Balderas%2C+Dehni+Irasema&rft.au=Hernandez%2C+Ivanna&rft.au=Vazquez-Mora%2C+Juan+Antonio&rft.date=2023-08-24&rft.issn=0304-3940&rft.volume=812&rft.spage=137402&rft_id=info:doi/10.1016%2Fj.neulet.2023.137402&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_neulet_2023_137402 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3940&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3940&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3940&client=summon |