Medicinal chemistry of muscarinic agonists for the treatment of dementia disorders

• Published in: European journal of drug metabolism and pharmacokinetics Vol. 19; no. 3; p. 179
• Main Authors: Cereda, E, Brambilla, A, Ezhaya, A, Gaida, W, Mendla, K, Monferini, E, Pitsikas, N, Schiavi, G B, Sagrada, A
• Format: Journal Article
• Language: English
• Published: France 01.07.1994
• Subjects: Alzheimer Disease - drug therapy; Animals; Brain - drug effects; CHO Cells; Cricetinae; Female; Learning - drug effects; Male; Muscarinic Agonists - metabolism; Muscarinic Agonists - pharmacology; Muscarinic Agonists - therapeutic use; Rabbits; Rats; Receptors, Muscarinic - metabolism

Alzheimer disease (AD) is a neurodegenerative disorder lacking an effective therapy. The etiology is controversial and among different drug strategies, the cholinergic approach has gained great interest owing to biochemical and pharmacological evidence of the crucial role of acetylcholine in cogniti...