Adenovirus-mediated gene transfer of dominant negative Ha-Ras inhibits proliferation of primary meningioma cells

• Published in: Neurosurgery Vol. 44; no. 3; p. 579
• Main Authors: Shu, J, Lee, J H, Harwalkar, J A, Oh-Siskovic, S, Stacey, D W, Golubić, M
• Format: Journal Article
• Language: English
• Published: United States 01.03.1999
• Subjects: Adenoviruses, Human - genetics; Cell Division - genetics; Gene Expression - genetics; Gene Transfer Techniques; Genes, Dominant - genetics; Genes, ras - genetics; Growth Substances - genetics; Humans; Meningioma - genetics; Meningioma - pathology; Phosphorylation; Point Mutation - genetics; Tumor Cells, Cultured

Previous studies demonstrated that activation of receptor tyrosine kinases in human meningiomas by an autocrine or paracrine growth-stimulatory loop plays an important role in meningioma proliferation. Although it is well established that the proliferative signal from protein tyrosine kinase recepto...