Reduction in MCP-1 production in preadipocytes is mediated by PPARγ activation and JNK/SIRT1 signaling - Sawamoto, Atsushi; Itagaki, Ibuki; Okuyama, Satoshi; Nakajima, Mitsunari (Biochimica et biophysica acta. General subjects, 2025)
Keywords: 3T3-L1 Cells; Adipocytes - drug effects; Adipocytes - metabolism; Animals; C-Jun N-terminal kinase (JNK); Chemokine CCL2 - biosynthesis; Chemokine CCL2 - metabolism; Insulin resistance; JNK Mitogen-Activated Protein Kinases - metabolism; Lipopolysaccharides - pharmacology; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred C57BL; Monocyte chemoattractant protein 1 (MCP-1); Peroxisome proliferator-activated receptor gamma (PPARγ); PPAR gamma - agonists; PPAR gamma - genetics; PPAR gamma - metabolism; Preadipocytes; Rosiglitazone; Signal Transduction - drug effects; Silent information regulator 2 homolog 1 (SIRT1); Sirtuin 1 - metabolism; Thiazolidinediones - pharmacology; PBS; MCP-1; SVF; JNK; RSG; Preadipocytes; Monocyte chemoattractant protein 1 (MCP-1); WAT; C-Jun N-terminal kinase (JNK); LPS; BSA; DMEM; LDH; FBS; Silent information regulator 2 homolog 1 (SIRT1); Insulin resistance; Peroxisome proliferator-activated receptor gamma (PPARγ); SEM; ELISA