The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice

• Published in: Bioorganic chemistry Vol. 147; p. 107364
• Main Authors: Li, Yining, Liu, Chao, Han, Xiaowan, Sheng, Ren, Bao, Li, Lei, Lijuan, Wu, Yexiang, Li, Quanjie, Zhang, Yuyan, Zhang, Jing, Wang, Weizhi, Zhang, Yuhao, Li, Shunwang, Wang, Chenyin, Wei, Xinwei, Wang, Jingrui, Peng, Zonggen, Xu, Yanni, Si, Shuyi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2024
• Subjects: Animals; Bone Resorption - drug therapy; Bone Resorption - metabolism; Bone Resorption - prevention & control; Cell Differentiation - drug effects; Dose-Response Relationship, Drug; Female; Mice; Molecular Structure; OPG; Osteoblast; Osteoclast; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteogenesis - drug effects; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - metabolism; Osteoporosis - prevention & control; Ovariectomy; PPAR delta - metabolism; PPARδ; RANKL; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction - drug effects; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Structure-Activity Relationship; Osteoblast; Osteoporosis; RANKL; Osteoclast; OPG; PPARδ

[Display omitted] •E0924G dually regulates bone formation and bone resorption in vitro.•E0924G significantly prevents bone loss in ovariectomized rats and SAMP6 senile mice.•E0924G regulates bone metabolism through activating the PPARδ signaling pathway. Osteoporosis is particularly prevalent among...