Systematic Assessment of Tumor Purity and Its Clinical Implications

• Published in: JCO precision oncology Vol. 4
• Main Authors: Haider, Syed, Tyekucheva, Svitlana, Prandi, Davide, Fox, Natalie S, Ahn, Jaeil, Xu, Andrew Wei, Pantazi, Angeliki, Park, Peter J, Laird, Peter W, Sander, Chris, Wang, Wenyi, Demichelis, Francesca, Loda, Massimo, Boutros, Paul C
• Format: Journal Article
• Language: English
• Published: United States 04.09.2020

The tumor microenvironment is complex, comprising heterogeneous cellular populations. As molecular profiles are frequently generated using bulk tissue sections, they represent an admixture of multiple cell types (including immune, stromal, and cancer cells) interacting with each other. Therefore, th...