Prevention by theophylline of beta-2-receptor down regulation in healthy subjects - Derks, Michiel G. M.; Koopmans, Richard P.; Oosterhoff, Els; van Boxtel, Chris J. (European journal of drug metabolism and pharmacokinetics, 2000)
Keywords: Biological and medical sciences; Cross-Over Studies; Double-Blind Method; Down-Regulation; Eosinophils - drug effects; Humans; Medical sciences; Pharmacology. Drug treatments; Potassium - blood; Receptors, Adrenergic, beta-2 - analysis; Receptors, Adrenergic, beta-2 - drug effects; Respiratory system; Terbutaline - pharmacokinetics; Theophylline - pharmacokinetics; Theophylline - pharmacology; Human; Pharmacokinetic pharmacodynamic relationship; Agonist; Drug combination; Desensitization; Healthy subject; Bronchodilator; β2-Adrenergic receptor; Antiasthma agent; Terbutaline; Activity concentration relation; Models; Xanthine derivatives; Pharmacokinetics; Theophylline