Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin

• Published in: International journal of clinical pharmacology and therapeutics Vol. 59; no. 1; pp. 71 - 86
• Main Authors: Ruggieri, Alessandro, Picollo, Rossella, Vecchio, Alessandra Del, Calisti, Fabrizio, Dragone, Patrizia, Comandini, Alessandro, Rosignoli, Maria T., Cattaneo, Agnese, Donath, Frank, Wedemeyer, Ralph-Steven, Todorova-Sanjari, Marina, Warnke, André, Blume, Henning H.
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.01.2021
• Subjects: Administration, Oral; Area Under Curve; Bioavailability; Chromatography, Liquid; Convulsions & seizures; Cross-Over Studies; Drug dosages; Drug Interactions; Gabapentin - adverse effects; Humans; Investigations; Oral administration; Pain; Pharmacokinetics; Plasma; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Trazodone - adverse effects

To establish dose proportionality for trazodone and gabapentin at fixed ratios of trazodone/gabapentin 2.5/25, 10/100, and 30/300 and investigation of potential drug-drug interaction at a dose of 10/100. 29 out of 30 healthy subjects completed this single-center, open-label, randomized, 5-period cro...