PPARα activators inhibit tissue factor expression and activity in human monocytes

• Published in: Circulation (New York, N.Y.) Vol. 103; no. 2; pp. 213 - 219
• Main Authors: MARX, Nikolaus, MACKMAN, Nigel, SCHÖNBECK, Uwe, YILMAZ, Nurcan, HOMBACH, Vinzenz, LIBBY, Peter, PLUTZKY, Jorge
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 16.01.2001
• Subjects: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Medical sciences; Vascular disease; Human; Cell culture; Monocyte; Pathogenesis; Atherosclerosis; Tissue factor; Cardiovascular disease; Thrombosis; Peroxisome proliferator; Biological receptor

Background —Tissue factor (TF), expressed on the surface of monocytes and macrophages in human atherosclerotic lesions, acts as the major procoagulant initiating thrombus formation in acute coronary syndromes. Peroxisome proliferator–activated receptor-α (PPARα), a nuclear receptor family member, re...