Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin

• Published in: Circulation. Cardiovascular imaging Vol. 18; no. 7; p. e017248
• Main Authors: Goudot, Guillaume, Abohashem, Shady, Osborne, Michael T., Aldosoky, Wesam, Ahmad, Taha Z., Lu, Michael T., Foldyna, Borek, Tawakol, Ahmed
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.07.2025
• Subjects: Adipose Tissue - diagnostic imaging; Adipose Tissue - drug effects; Aged; Aorta, Thoracic - diagnostic imaging; Aorta, Thoracic - drug effects; Aortitis - diagnostic imaging; Aortitis - drug therapy; Aortography - methods; Atorvastatin - therapeutic use; Double-Blind Method; Female; Fluorodeoxyglucose F18 - administration & dosage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Radiopharmaceuticals - administration & dosage; Treatment Outcome; risk factors; inflammation; spleen; arteritis; bone marrow

BACKGROUND: Imaging markers of atherosclerotic inflammation are needed to enhance cardiovascular risk assessment and evaluate the impact of therapies. We sought to test the hypothesis that treatments impacting arterial inflammation can be evaluated using a simplified measure of periaortic fat attenu...