TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss

• Published in: Journal of reproductive immunology Vol. 155; p. 103776
• Main Authors: Zeng, Shanshan, Liang, Yingyu, Lai, Siying, Bi, Shilei, Huang, Lijun, Li, Yulian, Deng, Weinan, Xu, Pei, Liu, Mingxing, Xiong, Zhongtang, Chen, Jingsi, Tu, Zhaowei, Chen, Dunjin, Du, Lili
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2023
• Subjects: Abortion, Habitual - pathology; Cellular senescence; Decidua - pathology; Decidual stromal cells; Endometrium - pathology; Female; Humans; Pregnancy; Receptors, Tumor Necrosis Factor, Type I - genetics; Receptors, Tumor Necrosis Factor, Type I - metabolism; Recurrent pregnancy loss; Stromal Cells - metabolism; TNFR1; TNFα; Tumor Necrosis Factor-alpha - metabolism; IGFBP1; CS-FBS; TNFα; SA-βgal; VCT; Cellular senescence; dbcAMP; TMA; PRL; Decidual stromal cells; SASP; hCG; TNF; RPL; TNFR1; ASRM; P/S; Recurrent pregnancy loss; ESCs; ESHRE; DSCs; MPA

Defects in decidual response are associated with adverse pregnancy outcomes which includes recurrent pregnancy loss (RPL). It is reported that cellular senescence happens during decidualization and pro-senescent decidual response in the luteal phase endometrium is related to RPL. However, the underl...