Gα12-Mediated Pathway Promotes Invasiveness of Nasopharyngeal Carcinoma by Modulating Actin Cytoskeleton Reorganization

• Published in: Cancer research (Chicago, Ill.) Vol. 69; no. 15; pp. 6122 - 6130
• Main Authors: Liu, Shu-Chen, Jen, Yee-Min, Jiang, Shih Sheng, Chang, Junn-Liang, Hsiung, Chao A., Wang, Chih-Hung, Juang, Jyh-Lyh
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2009
• Subjects: Antineoplastic agents; Biological and medical sciences; Medical sciences; Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Actin; Nasopharynx cancer; Contractile protein; ENT disease; Cytoskeleton; Pharynx disease; Malignant tumor; Nasopharynx carcinoma; Metastasis; Cancer

The molecular mechanisms behind the aggressiveness of nasopharyngeal carcinoma (NPC), a highly invasive and metastatic head and neck malignancy, have not been made clear. In this study investigating these mechanisms, guanine nucleotide-binding protein α12 subunit (Gα12) signaling was found by microa...