Epidemiological, clinical, and histological presentation of celiac disease in Northwest China
Research on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and pathological characteristics of CD are limited. To investigate the epidemiological, clinical, and pathological characteristics of CD in northwest China. The...
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Published in | World journal of gastroenterology : WJG Vol. 28; no. 12; pp. 1272 - 1283 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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28.03.2022
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Abstract | Research on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and pathological characteristics of CD are limited.
To investigate the epidemiological, clinical, and pathological characteristics of CD in northwest China.
The clinical data of 2884 patients with gastrointestinal (GI) symptoms were retrospectively analyzed. Total immunoglobulin A (IgA) and anti-tissue transglutaminase (tTG) IgA levels were examined in all patients. Gastroscopy and colonoscopy were performed in patients with positive anti-tTG IgA and deficient total IgA levels. Atrophy of the duodenal and ileal villi was examined and histopathological examinations were performed. The modified Marsh-Oberhuber classification system was used to grade villous atrophy in the duodenum or distal ileum. The patients'
(
) infection status was compared in terms of clinical presentation and Marsh grade. Statistical analyses were performed using the t-test or chi-square test.
Among the 2884 patients, 73 were positive for serum anti-tTG IgA, and 50 were diagnosed with CD. The CD detection rate was significantly higher in Kazakhs (4.39%) than in Uyghurs (2.19%), Huis (0.71%), and Hans (0.55%). The main symptoms of CD were chronic diarrhea, anorexia, anemia, fatigue, weight loss, sleep disorders, osteopenia, and osteoporosis. The body mass index of patients with CD was significantly lower than that of patients without CD. A total of 69 patients with positive serum anti-tTG IgA and two patients with deficient total IgA levels underwent GI endoscopy. Endoscopy revealed crypt hyperplasia and/or duodenal villous atrophy, mainly manifested as nodular mucosal atrophy, grooves, and fissures. The difference in
infection rates was not statistically significant between CD and non-CD patients but was significantly different among CD patients with different Marsh grades.
Among the patients with GI symptoms in northwestern China, the prevalence of CD was more in the Uyghur and Kazakh populations.
infection may be associated with CD severity. |
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AbstractList | BACKGROUNDResearch on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and pathological characteristics of CD are limited. AIMTo investigate the epidemiological, clinical, and pathological characteristics of CD in northwest China. METHODSThe clinical data of 2884 patients with gastrointestinal (GI) symptoms were retrospectively analyzed. Total immunoglobulin A (IgA) and anti-tissue transglutaminase (tTG) IgA levels were examined in all patients. Gastroscopy and colonoscopy were performed in patients with positive anti-tTG IgA and deficient total IgA levels. Atrophy of the duodenal and ileal villi was examined and histopathological examinations were performed. The modified Marsh-Oberhuber classification system was used to grade villous atrophy in the duodenum or distal ileum. The patients' Helicobacter pylori (H. pylori) infection status was compared in terms of clinical presentation and Marsh grade. Statistical analyses were performed using the t-test or chi-square test. RESULTSAmong the 2884 patients, 73 were positive for serum anti-tTG IgA, and 50 were diagnosed with CD. The CD detection rate was significantly higher in Kazakhs (4.39%) than in Uyghurs (2.19%), Huis (0.71%), and Hans (0.55%). The main symptoms of CD were chronic diarrhea, anorexia, anemia, fatigue, weight loss, sleep disorders, osteopenia, and osteoporosis. The body mass index of patients with CD was significantly lower than that of patients without CD. A total of 69 patients with positive serum anti-tTG IgA and two patients with deficient total IgA levels underwent GI endoscopy. Endoscopy revealed crypt hyperplasia and/or duodenal villous atrophy, mainly manifested as nodular mucosal atrophy, grooves, and fissures. The difference in H. pylori infection rates was not statistically significant between CD and non-CD patients but was significantly different among CD patients with different Marsh grades. CONCLUSIONAmong the patients with GI symptoms in northwestern China, the prevalence of CD was more in the Uyghur and Kazakh populations. H. pylori infection may be associated with CD severity. Research on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and pathological characteristics of CD are limited. To investigate the epidemiological, clinical, and pathological characteristics of CD in northwest China. The clinical data of 2884 patients with gastrointestinal (GI) symptoms were retrospectively analyzed. Total immunoglobulin A (IgA) and anti-tissue transglutaminase (tTG) IgA levels were examined in all patients. Gastroscopy and colonoscopy were performed in patients with positive anti-tTG IgA and deficient total IgA levels. Atrophy of the duodenal and ileal villi was examined and histopathological examinations were performed. The modified Marsh-Oberhuber classification system was used to grade villous atrophy in the duodenum or distal ileum. The patients' ( ) infection status was compared in terms of clinical presentation and Marsh grade. Statistical analyses were performed using the t-test or chi-square test. Among the 2884 patients, 73 were positive for serum anti-tTG IgA, and 50 were diagnosed with CD. The CD detection rate was significantly higher in Kazakhs (4.39%) than in Uyghurs (2.19%), Huis (0.71%), and Hans (0.55%). The main symptoms of CD were chronic diarrhea, anorexia, anemia, fatigue, weight loss, sleep disorders, osteopenia, and osteoporosis. The body mass index of patients with CD was significantly lower than that of patients without CD. A total of 69 patients with positive serum anti-tTG IgA and two patients with deficient total IgA levels underwent GI endoscopy. Endoscopy revealed crypt hyperplasia and/or duodenal villous atrophy, mainly manifested as nodular mucosal atrophy, grooves, and fissures. The difference in infection rates was not statistically significant between CD and non-CD patients but was significantly different among CD patients with different Marsh grades. Among the patients with GI symptoms in northwestern China, the prevalence of CD was more in the Uyghur and Kazakh populations. infection may be associated with CD severity. |
Author | Shi, Tian Wang, Man Feng, Yan Li, Zi-Qiong Kong, Wen-Jie Cui, Mei Lu, Jia-Jie Hui, Wen-Jia Liu, Wei-Dong Gao, Feng Sun, Zhen-Zhu |
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Keywords | Celiac disease Gastrointestinal symptoms Pathology Helicobacter pylori infection Epidemiology |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Wang M and Gao F designed the study; Wang M, Kong WJ, and Lu JJ acquired the data and drafted the article; Hui WJ and Liu WD analyzed and interpreted the data; Cui M and Sun ZZ made a pathological diagnosis; Feng Y, Li ZQ, Shi T and Gao F revised the article critically for important intellectual content; all the authors approved the version to be published. Corresponding author: Feng Gao, PhD, Chairman, Chief Doctor, Director, Professor, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. drxjgf@sina.com Supported by National Natural Science Foundation of China, No. 81760101; and Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2021D01C149. |
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Snippet | Research on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and pathological... BACKGROUNDResearch on celiac disease (CD) in northwest China is still in its infancy. At present, large-sample data on the epidemiological, clinical, and... |
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SubjectTerms | Atrophy - epidemiology Atrophy - pathology Autoantibodies Celiac Disease - complications Celiac Disease - diagnosis Celiac Disease - epidemiology Duodenum - pathology Helicobacter Infections - complications Helicobacter Infections - diagnosis Helicobacter Infections - epidemiology Humans Immunoglobulin A Retrospective Studies Retrospective Study Transglutaminases |
Title | Epidemiological, clinical, and histological presentation of celiac disease in Northwest China |
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