Individualized Delivery of Vancomycin by Model-Informed Bayesian Dosing Approach to Maintain an AUC24 Target in Critically Ill Patients

• Published in: Chemotherapy (Basel) Vol. 69; no. 1; p. 49
• Main Authors: Rao, Zhi, Guo, Si-Ming, Wei, Yan-Ming
• Format: Journal Article
• Language: English
• Published: Switzerland 2024
• Subjects: Anti-Bacterial Agents - therapeutic use; Area Under Curve; Bayes Theorem; Critical Illness; Humans; Vancomycin - therapeutic use; AUC24 target; Individualized delivery; Vancomycin; Bayesian dosing approach; Critically ill patients

Monitoring of AUC24 was updated recommendation in the guideline for the therapeutic drug monitoring (TDM) of vancomycin in Chinese pharmacological society published in 2020. Vancomycin pharmacokinetic profiles are diverse and unique in critically ill patients because of the drastic variability of th...