Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling

• Published in: The Journal of biological chemistry Vol. 282; no. 18; pp. 13833 - 13844
• Main Authors: Nizzari, Mario, Venezia, Valentina, Repetto, Emanuela, Caorsi, Valentina, Magrassi, Raffaella, Gagliani, Maria Cristina, Carlo, Pia, Florio, Tullio, Schettini, Gennaro, Tacchetti, Carlo, Russo, Tommaso, Diaspro, Alberto, Russo, Claudio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.05.2007; American Society for Biochemistry and Molecular Biology
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Protein Precursor - metabolism; Cell Line; Centromere - metabolism; Centromere - ultrastructure; Fluorescence Resonance Energy Transfer; GRB2 Adaptor Protein - metabolism; Humans; MAP Kinase Signaling System; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Presenilin-1 - metabolism; Presenilin-2 - metabolism; Protein Binding

The amyloid precursor protein (APP) and the presenilins 1 and 2 are genetically linked to the development of familial Alzheimer disease. APP is a single-pass transmembrane protein and precursor of fibrillar and toxic amyloid-β peptides, which are considered responsible for Alzheimer disease neurodeg...