Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: Insights from computational model for circadian-neuroendocrine-immune interactions

• Published in: American journal of physiology: endocrinology and metabolism Vol. 319; no. 1; pp. E48 - E66
• Main Authors: Somvanshi, Pramod R, Mellon, Synthia H, Yehuda, Rachel, Flory, Janine D, Bierer, Linda, Makotkine, Iouri, Marmar, Charles, Jett, Marti, Doyle Iii, Francis J
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: circadian; neuro-endocrine immune axis; Inflammation; PTSD systems biology; Glucocorticoid sensitivity

Although glucocorticoid resistance contributes to increased inflammation, individuals with post-traumatic stress disorder (PTSD) exhibit increased glucocorticoid receptor (GR) sensitivity along with increased inflammation. It is not clear how inflammation co-exists with a hyper-responsive hypothalam...