Synthetic and anti-cancer activity aspects of 1, 3, 4-thiadiazole containing bioactive molecules: A concise review

Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the development of novel, more effective anticancer therapeutics. In recent years, small molecules containing five-member heterocyclic moieties...

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Published inJournal of sulfur chemistry Vol. 42; no. 6; pp. 670 - 691
Main Authors Obakachi, Vincent A., Kushwaha, Babita, Kushwaha, Narva Deshwar, Mokoena, Sithabile, Ganai, Ab Majeed, Pathan, Tabasum Khan, van Zyl, Werner E., Karpoormath, Rajshekhar
Format Journal Article
LanguageEnglish
Published Taylor & Francis 02.11.2021
Subjects
1,3,4-Thiadiazole
anticancer activity
cytotoxicity
SAR
synthesis
Online AccessGet full text
ISSN1741-5993
1741-6000
DOI10.1080/17415993.2021.1963441

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Abstract Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the development of novel, more effective anticancer therapeutics. In recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new anticancer agents. An example is the 1,3,4-thiadiazole, a versatile scaffold widely studied in medicinal chemistry. The mesoionic character of the ring allows 1,3,4-thiadiazole-containing derivatives to cross the cellular membrane and interact strongly with biological targets leading to the possibility of low toxicity and high selectivity. This review attempts to collect the recent updates of synthetic methodology, structural activity relationship (SAR), and anticancer properties of 1,3,4-thiadiazole embedded derivatives, which can be considered potential anticancer agents.
AbstractList Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the development of novel, more effective anticancer therapeutics. In recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new anticancer agents. An example is the 1,3,4-thiadiazole, a versatile scaffold widely studied in medicinal chemistry. The mesoionic character of the ring allows 1,3,4-thiadiazole-containing derivatives to cross the cellular membrane and interact strongly with biological targets leading to the possibility of low toxicity and high selectivity. This review attempts to collect the recent updates of synthetic methodology, structural activity relationship (SAR), and anticancer properties of 1,3,4-thiadiazole embedded derivatives, which can be considered potential anticancer agents.
Author Ganai, Ab Majeed
Kushwaha, Narva Deshwar
Obakachi, Vincent A.
Kushwaha, Babita
Mokoena, Sithabile
van Zyl, Werner E.
Pathan, Tabasum Khan
Karpoormath, Rajshekhar
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Snippet Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the...
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SubjectTerms 1,3,4-Thiadiazole
anticancer activity
cytotoxicity
SAR
synthesis
Title Synthetic and anti-cancer activity aspects of 1, 3, 4-thiadiazole containing bioactive molecules: A concise review
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