Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism - Kato, Akihiko S; Burris, Kevin D; Gardinier, Kevin M; Gernert, Douglas L; Porter, Warren J; Reel, Jon; Ding, Chunjin; Tu, Yuan; Schober, Douglas A; Lee, Matthew R; Heinz, Beverly A; Fitch, Thomas E; et al. (Nature medicine, 2016)
Keywords: 692/617/375/178; Animals; Anticonvulsants - adverse effects; Anticonvulsants - pharmacology; Benzothiazoles - pharmacology; Biomedicine; Calcium Channels - metabolism; Cancer Research; Cerebellum - drug effects; Cerebellum - metabolism; Convulsants - toxicity; Disease Models, Animal; Dizziness - chemically induced; Epilepsy - chemically induced; Epilepsy - drug therapy; Infectious Diseases; letter; Metabolic Diseases; Mice; Molecular Medicine; Neurosciences; Pentylenetetrazole - toxicity; Prosencephalon - drug effects; Prosencephalon - metabolism; Pyrazoles - pharmacology; Pyridones - adverse effects; Pyridones - pharmacology; Rats; Receptors, AMPA - antagonists & inhibitors; Receptors, AMPA - metabolism; Seizures - chemically induced; Seizures - drug therapy