Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers

Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear...

Full description

Saved in:
Bibliographic Details
Published inLife (Basel, Switzerland) Vol. 14; no. 7; p. 806
Main Authors Garcia-Queiruga, Jacobo, Pena-Verdeal, Hugo, Sabucedo-Villamarin, Belen, Garcia-Resua, Carlos, Giraldez, Maria J, Yebra-Pimentel, Eva
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.06.2024
Subjects
bulbar hyperemia
Cornea
Disease
Drug therapy
dry eye disease
Eye
Eye diseases
Homeostasis
Hyperemia
lipid layer pattern
Lipids
long-term follow-up
Longitudinal studies
Optometry
Patients
Signs and symptoms
tear meniscus height
Japan
dry eye disease
bulbar hyperemia
lipid layer pattern
tear meniscus height
long-term follow-up
Online AccessGet full text

Cover

Abstract Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group ( ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group ( ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group ( < 0.005). Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.
AbstractList Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group ( ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group ( ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group ( < 0.005). Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.
Background: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. Methods: This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Results: Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005). Conclusion: Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.
Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants.BACKGROUNDDry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants.This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED.METHODSThis retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED.Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005).RESULTSDifferences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005).Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.CONCLUSIONChanges in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.
Author Garcia-Resua, Carlos
Sabucedo-Villamarin, Belen
Pena-Verdeal, Hugo
Yebra-Pimentel, Eva
Giraldez, Maria J
Garcia-Queiruga, Jacobo
Author_xml – sequence: 1
  givenname: Jacobo
  orcidid: 0000-0001-7216-4512
  surname: Garcia-Queiruga
  fullname: Garcia-Queiruga, Jacobo
  organization: AC-24 Optometry, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana, 15701 Santiago de Compostela, Spain
– sequence: 2
  givenname: Hugo
  orcidid: 0000-0001-5103-1374
  surname: Pena-Verdeal
  fullname: Pena-Verdeal, Hugo
  organization: AC-24 Optometry, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana, 15701 Santiago de Compostela, Spain
– sequence: 3
  givenname: Belen
  orcidid: 0000-0001-5032-620X
  surname: Sabucedo-Villamarin
  fullname: Sabucedo-Villamarin, Belen
  organization: GI-2092 Optometry, Departamento de Física Aplicada, Facultad de Óptica y Optometría, Universidade de Santiago de Compostela, Campus Vida s/n, 15701 Santiago de Compostela, Spain
– sequence: 4
  givenname: Carlos
  surname: Garcia-Resua
  fullname: Garcia-Resua, Carlos
  organization: AC-24 Optometry, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana, 15701 Santiago de Compostela, Spain
– sequence: 5
  givenname: Maria J
  orcidid: 0000-0001-9595-7486
  surname: Giraldez
  fullname: Giraldez, Maria J
  organization: AC-24 Optometry, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana, 15701 Santiago de Compostela, Spain
– sequence: 6
  givenname: Eva
  surname: Yebra-Pimentel
  fullname: Yebra-Pimentel, Eva
  organization: AC-24 Optometry, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana, 15701 Santiago de Compostela, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39063561$$D View this record in MEDLINE/PubMed
BookMark eNpdkUlrHDEQhUVwiNdbzkaQSw6euNTauo9hMl7AkICXq1CrS46GntZY6j7Mv7fGYxtjXaQSXz1e1Tske0MckJDvDH5x3sB5HzwyARpqUF_IQQVazpiumr0P731ykvMSylGSqVp8I_ulVXGp2AExd7hax2R7-i_Fx4Q5hzjQ6OliGNOGXlg3xpRpGMZIx_9IH4ILccp0HpLrcQv-KdhigwWh96UH7YgdvZ28x4QpH5Ov3vYZT17vI3J_sbibX81u_l5ez3_fzBxnMM46LWUjfFtbJyvNpOQeGwQBotFCgUXR-ka5Chyo2rdWaKtrWzutSy214EfkeqfbRbs06xRWNm1MtMG8fMT0aGwaQ_FsvIKKo-ZcoRKVZ2V1HbatkhUTVoMrWj93WusUnybMo1mF7LDv7YBldsOhlow1Na8K-uMTuoxTGsqkW0o0HCRAoc52lEsx54T-3SADs83RfMyx4KevolO7wu4dfkuNPwNHFpeO
Cites_doi 10.1136/bjophthalmol-2015-307415
10.1016/S1367-0484(98)80035-0
10.1016/j.jtos.2023.04.008
10.1016/j.jtos.2017.05.001
10.1097/ICL.0b013e31825fed57
10.1111/j.1475-1313.2010.00815.x
10.1097/01.ICL.0000138714.96401.2b
10.1016/j.jtos.2021.05.001
10.1016/j.ophtha.2015.10.011
10.1097/OPX.0000000000001610
10.1016/j.clae.2022.101744
10.1038/s41433-022-02281-2
10.1155/2016/8013621
10.3390/life12122007
10.1007/s10792-023-02632-2
10.1016/j.clae.2020.03.014
10.1080/02713683.2017.1377261
10.1016/j.exer.2020.108115
10.1016/j.jtos.2017.05.008
10.1080/02713683.2022.2039205
10.1016/j.jtos.2017.05.003
10.1016/j.jtos.2021.05.003
10.1007/978-1-4615-5359-5_121
10.1097/ICL.0000000000000467
10.1080/02713683.2017.1393092
10.1159/000505630
10.1080/09273948.2022.2075398
10.1016/j.clae.2022.101800
10.1016/S1542-0124(12)70299-9
10.1001/archopht.118.5.615
10.1159/000525696
10.1016/j.jtos.2023.04.011
10.1016/j.jtos.2023.04.010
10.1016/j.jtos.2017.05.011
10.1097/00006324-199303000-00011
10.1016/j.clae.2014.07.006
10.1080/01676830.2020.1814352
10.1016/j.jtos.2023.06.004
ContentType Journal Article
Copyright 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID NPM
AAYXX
CITATION
8FD
8FE
8FH
ABUWG
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
COVID
DWQXO
FR3
GNUQQ
HCIFZ
LK8
M7P
P64
PATMY
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PYCSY
RC3
7X8
DOA
DOI 10.3390/life14070806
DatabaseName PubMed
CrossRef
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
Coronavirus Research Database
ProQuest Central
Engineering Research Database
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Biological Sciences
Biological Science Database
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Genetics Abstracts
Natural Science Collection
ProQuest Central Korea
Agricultural & Environmental Science Collection
Biological Science Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Coronavirus Research Database
Biological Science Database
ProQuest SciTech Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
ProQuest One Academic UKI Edition
Environmental Science Database
Engineering Research Database
ProQuest One Academic
MEDLINE - Academic
DatabaseTitleList PubMed

Publicly Available Content Database
MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2075-1729
ExternalDocumentID oai_doaj_org_article_f6023e7336e642f1806debb65214a70c
10_3390_life14070806
39063561
Genre Journal Article
GeographicLocations Japan
GeographicLocations_xml – name: Japan
GroupedDBID 53G
5VS
7XC
8FE
8FH
AADQD
AAFWJ
ABDBF
ADBBV
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
DIK
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
ISR
ITC
KQ8
LK8
M48
M7P
MODMG
M~E
NPM
OK1
PATMY
PGMZT
PIMPY
PROAC
PYCSY
RIG
RPM
AAYXX
CITATION
8FD
ABUWG
AZQEC
COVID
DWQXO
FR3
GNUQQ
P64
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
ID FETCH-LOGICAL-c310t-d75594fb8ac5271553fe9e040497460ae4bf96c20c068fba47a78a8c770685743
IEDL.DBID M48
ISSN 2075-1729
IngestDate Fri Oct 04 13:16:06 EDT 2024
Sat Aug 17 04:23:08 EDT 2024
Thu Oct 10 22:41:11 EDT 2024
Thu Sep 26 21:31:33 EDT 2024
Fri Oct 18 08:46:49 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords dry eye disease
bulbar hyperemia
lipid layer pattern
tear meniscus height
long-term follow-up
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c310t-d75594fb8ac5271553fe9e040497460ae4bf96c20c068fba47a78a8c770685743
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-5032-620X
0000-0001-5103-1374
0000-0001-7216-4512
0000-0001-9595-7486
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.proquest.com/docview/3084930500?pq-origsite=%requestingapplication%
PMID 39063561
PQID 3084930500
PQPubID 2032373
ParticipantIDs doaj_primary_oai_doaj_org_article_f6023e7336e642f1806debb65214a70c
proquest_miscellaneous_3085119832
proquest_journals_3084930500
crossref_primary_10_3390_life14070806
pubmed_primary_39063561
PublicationCentury 2000
PublicationDate 2024-Jun-26
PublicationDateYYYYMMDD 2024-06-26
PublicationDate_xml – month: 06
  year: 2024
  text: 2024-Jun-26
  day: 26
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Life (Basel, Switzerland)
PublicationTitleAlternate Life (Basel)
PublicationYear 2024
Publisher MDPI AG
Publisher_xml – name: MDPI AG
References Wang (ref_16) 2020; 63
Galor (ref_4) 2023; 28
Beltran (ref_22) 2013; 54
Bron (ref_32) 2009; 7
Wolffsohn (ref_18) 2021; 21
Pult (ref_39) 2018; 44
Miller (ref_36) 2004; 30
Li (ref_38) 2012; 38
Cervino (ref_20) 2023; 46
Stapleton (ref_31) 2017; 15
Lienert (ref_34) 2016; 123
Pflugfelder (ref_35) 2020; 197
Craig (ref_1) 2017; 15
Pan (ref_15) 2017; 2
McMonnies (ref_19) 2017; 42
Lo (ref_33) 2021; 40
Wolffsohn (ref_9) 2017; 15
Bron (ref_10) 2017; 15
Akowuah (ref_2) 2020; 97
Cai (ref_3) 2022; 65
Markoulli (ref_40) 2018; 43
Singh (ref_41) 2023; 37
(ref_5) 2021; 105
Vehof (ref_13) 2020; 38
Giraldez (ref_43) 2023; 31
Minones (ref_27) 2014; 37
Giraldez (ref_6) 2023; 43
Gomes (ref_23) 2023; 29
Tian (ref_24) 2016; 2016
Schiffman (ref_21) 2000; 118
Jones (ref_8) 2023; 29
Baudouin (ref_11) 2016; 100
Rolando (ref_12) 2022; 47
Giraldez (ref_17) 2023; 29
Barabino (ref_14) 2020; 24
ref_26
Guillon (ref_28) 1998; 21
Giraldez (ref_7) 2023; 46
Bilkhu (ref_37) 2021; 44
Guillon (ref_25) 1998; 438
Singh (ref_42) 2021; 21
Terry (ref_29) 1993; 70
Armstrong (ref_30) 2011; 31
References_xml – volume: 100
  start-page: 300
  year: 2016
  ident: ref_11
  article-title: Revisiting the vicious circle of dry eye disease: A focus on the pathophysiology of meibomian gland dysfunction
  publication-title: Br. J. Ophthalmol.
  doi: 10.1136/bjophthalmol-2015-307415
  contributor:
    fullname: Baudouin
– volume: 21
  start-page: S31
  year: 1998
  ident: ref_28
  article-title: Non-invasive tearscope plus routine for contact lens fitting
  publication-title: Contact Lens Anterior Eye
  doi: 10.1016/S1367-0484(98)80035-0
  contributor:
    fullname: Guillon
– volume: 28
  start-page: 262
  year: 2023
  ident: ref_4
  article-title: TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2023.04.008
  contributor:
    fullname: Galor
– volume: 15
  start-page: 539
  year: 2017
  ident: ref_9
  article-title: TFOS DEWS II Diagnostic Methodology report
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2017.05.001
  contributor:
    fullname: Wolffsohn
– volume: 38
  start-page: 282
  year: 2012
  ident: ref_38
  article-title: Daytime variations of tear osmolarity and tear meniscus volume
  publication-title: Eye Contact Lens
  doi: 10.1097/ICL.0b013e31825fed57
  contributor:
    fullname: Li
– volume: 31
  start-page: 123
  year: 2011
  ident: ref_30
  article-title: Statistical guidelines for clinical studies of human vision
  publication-title: Ophthalmic Physiol. Opt.
  doi: 10.1111/j.1475-1313.2010.00815.x
  contributor:
    fullname: Armstrong
– volume: 30
  start-page: 132
  year: 2004
  ident: ref_36
  article-title: A comparison of tear volume (by tear meniscus height and phenol red thread test) and tear fluid osmolality measures in non-lens wearers and in contact lens wearers
  publication-title: Eye Contact Lens
  doi: 10.1097/01.ICL.0000138714.96401.2b
  contributor:
    fullname: Miller
– volume: 21
  start-page: 58
  year: 2021
  ident: ref_18
  article-title: Demographic and lifestyle risk factors of dry eye disease subtypes: A cross-sectional study
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2021.05.001
  contributor:
    fullname: Wolffsohn
– volume: 123
  start-page: 425
  year: 2016
  ident: ref_34
  article-title: Long-term Natural History of Dry Eye Disease from the Patient’s Perspective
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2015.10.011
  contributor:
    fullname: Lienert
– volume: 105
  start-page: 507
  year: 2021
  ident: ref_5
  article-title: Assessment of dry eye symptoms among university students during the COVID-19 pandemic
  publication-title: Clin. Exp. Optom.
– volume: 97
  start-page: 1089
  year: 2020
  ident: ref_2
  article-title: Prevalence of Dry Eye Disease in Africa: A Systematic Review and Meta-analysis
  publication-title: Optom. Vis. Sci. Off. Publ. Am. Acad. Optom.
  doi: 10.1097/OPX.0000000000001610
  contributor:
    fullname: Akowuah
– volume: 46
  start-page: 101744
  year: 2023
  ident: ref_20
  article-title: The effects of breaks on digital eye strain, dry eye and binocular vision: Testing the 20-20-20 rule
  publication-title: Contact Lens Anterior Eye
  doi: 10.1016/j.clae.2022.101744
  contributor:
    fullname: Cervino
– volume: 37
  start-page: 2042
  year: 2023
  ident: ref_41
  article-title: Repeatability, reproducibility and agreement between three different diagnostic imaging platforms for tear film evaluation of normal and dry eye disease
  publication-title: Eye
  doi: 10.1038/s41433-022-02281-2
  contributor:
    fullname: Singh
– volume: 2016
  start-page: 8013621
  year: 2016
  ident: ref_24
  article-title: Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease
  publication-title: J. Ophthalmol.
  doi: 10.1155/2016/8013621
  contributor:
    fullname: Tian
– ident: ref_26
  doi: 10.3390/life12122007
– volume: 43
  start-page: 2349
  year: 2023
  ident: ref_6
  article-title: Meibomian gland secretion quality association with ocular parameters in university students during COVID-19 restrictions
  publication-title: Int. Ophthalmol.
  doi: 10.1007/s10792-023-02632-2
  contributor:
    fullname: Giraldez
– volume: 44
  start-page: 24
  year: 2021
  ident: ref_37
  article-title: Provocation of the ocular surface to investigate the evaporative pathophysiology of dry eye disease
  publication-title: Contact Lens Anterior Eye
  doi: 10.1016/j.clae.2020.03.014
  contributor:
    fullname: Bilkhu
– volume: 42
  start-page: 1574
  year: 2017
  ident: ref_19
  article-title: Conjunctival Tear Layer Temperature, Evaporation, Hyperosmolarity, Inflammation, Hyperemia, Tissue Damage, and Symptoms: A Review of an Amplifying Cascade
  publication-title: Curr. Eye Res.
  doi: 10.1080/02713683.2017.1377261
  contributor:
    fullname: McMonnies
– volume: 197
  start-page: 108115
  year: 2020
  ident: ref_35
  article-title: Biological functions of tear film
  publication-title: Exp. Eye Res.
  doi: 10.1016/j.exer.2020.108115
  contributor:
    fullname: Pflugfelder
– volume: 15
  start-page: 276
  year: 2017
  ident: ref_1
  article-title: TFOS DEWS II Definition and Classification Report
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2017.05.008
  contributor:
    fullname: Craig
– volume: 2
  start-page: CD009327
  year: 2017
  ident: ref_15
  article-title: Autologous serum eye drops for dry eye
  publication-title: Cochrane Database Syst. Rev.
  contributor:
    fullname: Pan
– volume: 47
  start-page: 813
  year: 2022
  ident: ref_12
  article-title: Management Strategies for Evaporative Dry Eye Disease and Future Perspective
  publication-title: Curr. Eye Res.
  doi: 10.1080/02713683.2022.2039205
  contributor:
    fullname: Rolando
– volume: 15
  start-page: 334
  year: 2017
  ident: ref_31
  article-title: TFOS DEWS II Epidemiology Report
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2017.05.003
  contributor:
    fullname: Stapleton
– volume: 21
  start-page: 134
  year: 2021
  ident: ref_42
  article-title: Ocular redness—I: Etiology, pathogenesis, and assessment of conjunctival hyperemia
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2021.05.003
  contributor:
    fullname: Singh
– volume: 438
  start-page: 859
  year: 1998
  ident: ref_25
  article-title: Use of the Tearscope Plus and attachments in the routine examination of the marginal dry eye contact lens patient
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4615-5359-5_121
  contributor:
    fullname: Guillon
– volume: 44
  start-page: S318
  year: 2018
  ident: ref_39
  article-title: Relationships Between Meibomian Gland Loss and Age, Sex, and Dry Eye
  publication-title: Eye Contact Lens
  doi: 10.1097/ICL.0000000000000467
  contributor:
    fullname: Pult
– volume: 43
  start-page: 155
  year: 2018
  ident: ref_40
  article-title: Imaging the Tear Film: A Comparison Between the Subjective Keeler Tearscope-Plus and the Objective Oculus(R) Keratograph 5M and LipiView(R) Interferometer
  publication-title: Curr. Eye Res.
  doi: 10.1080/02713683.2017.1393092
  contributor:
    fullname: Markoulli
– volume: 38
  start-page: 301
  year: 2020
  ident: ref_13
  article-title: Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjogren’s syndrome
  publication-title: Clin. Exp. Rheumatol.
  contributor:
    fullname: Vehof
– volume: 63
  start-page: 443
  year: 2020
  ident: ref_16
  article-title: Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  publication-title: Ophthalmic Res.
  doi: 10.1159/000505630
  contributor:
    fullname: Wang
– volume: 31
  start-page: 970
  year: 2023
  ident: ref_43
  article-title: Analysis of the Differences in Ocular Surface Damage and Inflammatory Signs between Healthy and Evaporative Dry Eye Participants
  publication-title: Ocul. Immunol. Inflamm.
  doi: 10.1080/09273948.2022.2075398
  contributor:
    fullname: Giraldez
– volume: 46
  start-page: 101800
  year: 2023
  ident: ref_7
  article-title: A cross-sectional study of non-modifiable and modifiable risk factors of dry eye disease states
  publication-title: Contact Lens Anterior Eye
  doi: 10.1016/j.clae.2022.101800
  contributor:
    fullname: Giraldez
– volume: 7
  start-page: 78
  year: 2009
  ident: ref_32
  article-title: Predicted phenotypes of dry eye: Proposed consequences of its natural history
  publication-title: Ocul. Surf.
  doi: 10.1016/S1542-0124(12)70299-9
  contributor:
    fullname: Bron
– volume: 118
  start-page: 615
  year: 2000
  ident: ref_21
  article-title: Reliability and validity of the Ocular Surface Disease Index
  publication-title: Arch. Ophthalmol.
  doi: 10.1001/archopht.118.5.615
  contributor:
    fullname: Schiffman
– volume: 65
  start-page: 647
  year: 2022
  ident: ref_3
  article-title: Prevalence and incidence of dry eye disease in Asia: A systematic review and meta-analysis
  publication-title: Ophthalmic Res.
  doi: 10.1159/000525696
  contributor:
    fullname: Cai
– volume: 29
  start-page: 331
  year: 2023
  ident: ref_23
  article-title: TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2023.04.011
  contributor:
    fullname: Gomes
– volume: 29
  start-page: 175
  year: 2023
  ident: ref_8
  article-title: TFOS Lifestyle: Impact of contact lenses on the ocular surface
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2023.04.010
  contributor:
    fullname: Jones
– volume: 15
  start-page: 438
  year: 2017
  ident: ref_10
  article-title: TFOS DEWS II pathophysiology report
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2017.05.011
  contributor:
    fullname: Bron
– volume: 70
  start-page: 234
  year: 1993
  ident: ref_29
  article-title: CCLRU standards for success of daily and extended wear contact lenses
  publication-title: Optom. Vis. Sci. Off. Publ. Am. Acad. Optom.
  doi: 10.1097/00006324-199303000-00011
  contributor:
    fullname: Terry
– volume: 24
  start-page: 8642
  year: 2020
  ident: ref_14
  article-title: Dry eye disease treatment: The role of tear substitutes, their future, and an updated classification
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  contributor:
    fullname: Barabino
– volume: 37
  start-page: 431
  year: 2014
  ident: ref_27
  article-title: Interobserver and intraobserver repeatability of lipid layer pattern evaluation by two experienced observers
  publication-title: Contact Lens Anterior Eye
  doi: 10.1016/j.clae.2014.07.006
  contributor:
    fullname: Minones
– volume: 40
  start-page: 389
  year: 2021
  ident: ref_33
  article-title: Natural history of inflammatory and non-inflammatory dry eye in thyroid eye disease
  publication-title: Orbit
  doi: 10.1080/01676830.2020.1814352
  contributor:
    fullname: Lo
– volume: 54
  start-page: 6050
  year: 2013
  ident: ref_22
  article-title: Transcultural validation of ocular surface disease index (osdi) questionnaire for mexican population
  publication-title: Investig. Ophthalmol. Vis. Sci.
  contributor:
    fullname: Beltran
– volume: 29
  start-page: 298
  year: 2023
  ident: ref_17
  article-title: Longitudinal analysis of variation in status and diagnostic stability of untreated dry eye disease
  publication-title: Ocul. Surf.
  doi: 10.1016/j.jtos.2023.06.004
  contributor:
    fullname: Giraldez
SSID ssj0000651684
Score 2.3479419
Snippet Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial...
Background: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a...
SourceID doaj
proquest
crossref
pubmed
SourceType Open Website
Aggregation Database
Index Database
StartPage 806
SubjectTerms bulbar hyperemia
Cornea
Disease
Drug therapy
dry eye disease
Eye
Eye diseases
Homeostasis
Hyperemia
lipid layer pattern
Lipids
long-term follow-up
Longitudinal studies
Optometry
Patients
Signs and symptoms
tear meniscus height
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fS8MwEA4yEHwRf1udEkEfy9I2TdpHnRtDUAQ32VtJ0wQKo5Ote9h_713TjfkgvvjY9gjHXXP3Hbl8R8h9oiS3SqZ-BLnY57zQfhrHwleSFZCPU5VYvI38-iZGE_4yjac7o76wJ8zRAzvD9ayArGKQtM8AVLZBwkRh8lxA2uGwoG6ibxDvFFMuBseBSLjrdI-gru_NSmugmJCAkMSPHNRQ9f-OL5s8Mzwihy1ApI9OsWOyZ6oTsu9GRq5PSTZ2XFIz-o6dVY5Vg84tHeCEEDp043NoWdVzCtiOfpYau1xpv1zAcij4DGKDtQEROqmaPnNT0I9VMydlsTwjk-Fg3B_57ZAEXwMyq_1CQk3AbZ4oHYcSpwBZkxrYmhwqBcGU4blNhQ6ZZgLsrrhUMlGJlhKeY8AP56RTzStzSSigwVwWEYgIwZkJsION6ThQUhRMKuORh43Zsi_HhZFBDYHmzXbN65EntOlWBhmsmxfg16z1a_aXXz3S3Xgka7fVMotYwlOIUIx55G77GTYEnnKoyoA9UQbPRiFSeeTCeXKrCWiKfHzB1X9oeE0OQkA42DcWii7p1IuVuQGEUue3zc_4DQAP3_A
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Coronavirus Research Database
  dbid: COVID
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB7RRZV6aaEPmpYiV2qPAWfj2MmpKsuuoFIfUlnEzXIcG61ACd3NHuiv70ycXUqlcuCYZBI5mfHMN_aXGYAPuVHCG1XEKcbiWIjKxkWWydgoXmE8Lkzu6W_kr9_k8VR8Oc_O-wW3RU-rXPnEzlFXjaU18oOU56JA4-T80_WvmLpG0e5q30LjEWymOWY6A9gcfT87OVqvsmCATWQuAuM9xfz-4GrmHSYVCpGSvBOLupL9_8eZXbyZPAO9GmmgmVzuL9ty3_7-p4jjw19lC572UJR9DrazDRuufg6PQ3PKmxegT0PVqiv2gzhcoX4HazwbUy8SNgmNetisbhuGKJKdzSzxadloNsfHkeARio1vHIqwad0x2l3Ffi67jizzxUuYTsano-O4b8cQW8SAbVwpzD6EL3Njs6GifkPeFQ6dgMCcRHLjROkLaYfccokaNkIZlZvcKoXHGSKVVzCom9q9Boa4s1RViiJSCu4S4spxmyVGyYor4yL4uFKMvg5VNzRmK6RA_bcCIzgkra1lqFZ2d6KZX-h-6mkvEZc4KvvoMNnyCd5XubKUCFwEmqSNYHelJt1P4IW-1VEE79eXcerRfoqpHX5PkqFdWPSJEewEW1mPBEdKlf-SN_c__C08GSJKIu7ZUO7CoJ0v3TtEOW2515vyHzJW_F8
  priority: 102
  providerName: ProQuest
Title Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers
URI https://www.ncbi.nlm.nih.gov/pubmed/39063561
https://www.proquest.com/docview/3084930500
https://www.proquest.com/docview/3085119832/abstract/
https://doaj.org/article/f6023e7336e642f1806debb65214a70c
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1da9RAFL3UFsEXqZ9NW5cR9DE6yU5mkgcRu92lCq1Fu6VvYTKZyMKS1XQL3X_vuUl2aVHBp5DkJkzufNxzmJt7iN6k1qjKmiwcIhaHSpUuzJJEh9bIEvE4s2nFfyOfnumTqfpylVxt0VpttHfg9V-pHetJTZv5u9tfq4-Y8B-YcYKyv5_PKg-eYAB-9APaidVQ8Vg_7YF-tyYnkW7lh2PEyBBRO-uy4P94wb341Jbx_zf2bGPQZJce9-BRfOp6-wlt-fopPezkJFfPKL_o6kzNxTlnXXUVN8SiEmNWDxGTTlpHzOrlQgD3icuZ4wxYMZo1eB0bHsNsvPIwEdO6zUH3pfh-02qoNNfPaToZX4xOwl5AIXRAbcuwNOALqipS65LYsEJQ5TOPaavAIrS0XhVVpl0sndToE6uMNalNnTE4T4AtXtB2vaj9HgkgxcKUQ5horaSPOLtNuiSyRpfSWB_Q27Xb8p9dnYwc_ILdm991b0BH7NONDVe3bi8smh95P1nySgNJeC7U6EGPqgjPlb4oNKCGwiByAR2ueyRfj5h8KFOVYfWSMqDXm9uYLLwDYmsPf7IN75tiFQvoZdeTm5agpVyrL9r_zy85oEcxAA6njcX6kLaXzY1_BYCyLAa0czQ-O_-G4-jr5efjQUv0B-2I_A3BJ-Ns
link.rule.ids 315,786,790,870,2115,2236,21416,24346,27955,27956,33777,33778,38549,43838,43928,74657,74767
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9BJwQvfA8CA4wEj9mc1LGTJwRdqw62gUQ77c1yHBtVTMlo04fx13MXp-VDggcek1wiJ3e--539yx3Aq9wo4Y0q4iHG4liIysZFlsnYKF5hPC5M7ulv5JNTOZ2L9-fZeb_gtupplRuf2DnqqrG0Rn4w5Lko0Dg5f3P5LaauUbS72rfQuA47GFjTfAA7o49nR4fbVRYMsInMRWC8DzG_P7hYeIdJhUKkJH-LRV3J_r_jzC7eTO6A3ow00Ey-7q_bct9-_6OI4_-_yl243UNR9jbYzj245ur7cCM0p7x6AHoWqlZdsE_E4Qr1O1jj2Zh6kbBJaNTDFnXbMESR7GxhiU_LRoslPo4ED1FsfOVQhM3rjtHuKvZ53XVkWa4ewnwyno2mcd-OIbaIAdu4Uph9CF_mxmapon5D3hUOnYDAnERy40TpC2lTbrlEDRuhjMpNbpXC4wyRyi4M6qZ2j4Eh7ixVNUQRKQV3CXHluM0So2TFlXERvN4oRl-GqhsasxVSoP5VgRG8I61tZahWdneiWX7R_dTTXiIucVT20WGy5RO8r3JlKRG4CDRJG8HeRk26n8Ar_VNHEbzcXsapR_sppnb4PUmGdmHRJ0bwKNjKdiQ4Uqr8lzz598NfwM3p7ORYHx-dfngKt1JETMRDS-UeDNrl2j1DxNOWz3uz_gEd8_9G
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BKxCXllchtICR4Jius-vYyQm1-1DLo1SiW_VmOY6NVq2Sdjd7KL-emTi7PCQ4cUwyiZzMeOYb-8sMwNvMKOGNyuMBxuJYiNLGeZrK2CheYjzOTebpb-TPJ_JoKj5cpBcd_2nR0SpXPrF11GVtaY28N-CZyNE4Oe_5jhZxOpq8v76JqYMU7bR27TTuwiZCZImJ2Obwy_nxaL3igsE2kZkI7PcB5vq9q5l3mGAoRE3yt7jUlu__O-ZsY89kGy5Xow6Uk8v9ZVPs2-9_FHT8P6_1ELY6iMoOgk09gjuuegz3QtPK2yegz0I1qyt2StyuUNeD1Z6NqUcJm4QGPmxWNTVDdMnOZ5Z4tmw4m-PjSHCEYuNbhyJsWrVMd1eyr8u2U8t88RSmk_HZ8Cju2jTEFrFhE5cKsxLhi8zYtK-oD5F3uUPnIDBXkdw4Ufhc2j63XKLmjVBGZSazSuFxighmBzaqunLPgSEeLVQ5QBEpBXcJcei4TROjZMmVcRG8WylJX4dqHBqzGFKm_lWZERySBtcyVEO7PVHPv-luSmovEa84KgfpMAnzCd5XuqKQCGgEmqqNYG-lMt1N7IX-qa8I3qwv45SkfRZTOfyeJEO7s-grI3gW7GY9EhwpVQRMXvz74a_hPpqB_nR88nEXHvQRSBE9rS_3YKOZL91LBEJN8aqz8B9TvAgY
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Temporal+Progression+of+Entry+Factors+into+the+Vicious+Circle+of+Dry+Eye+in+Untreated+Sufferers&rft.jtitle=Life+%28Basel%2C+Switzerland%29&rft.au=Garcia-Queiruga%2C+Jacobo&rft.au=Pena-Verdeal%2C+Hugo&rft.au=Sabucedo-Villamarin%2C+Belen&rft.au=Garcia-Resua%2C+Carlos&rft.date=2024-06-26&rft.issn=2075-1729&rft.eissn=2075-1729&rft.volume=14&rft.issue=7&rft.spage=806&rft_id=info:doi/10.3390%2Flife14070806&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_life14070806
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-1729&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-1729&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-1729&client=summon