The chemicalome profiling of Zishen Yuzhen Pill in vivo and its promoting effect on osteogenic differentiation of MC3T3-E1 cells

• Published in: Frontiers in analytical science Vol. 5
• Main Authors: Cheng, Juanjuan, Meng, Xinyue, Fang, Daozheng, Zhu, Yong, Liu, Zhihao, Li, Xinyue, Jie, Ke, Huang, Shiying, Li, Huilin, Zhang, Shangbin, Chen, Jihang, Chen, Jianping
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 19.02.2025
• Subjects: chemical characterization; MC3T3-E1 cells; osteoporosis; UPLC-QTOF/MS; Zishen Yuzhen Pill

Zishen Yuzhen Pill (ZYP) is a Chinese herbal product developed by Shenzhen TCM Hospital, which have been frequently used to treat osteoporosis (OP). This study aimed to determine the major chemical components of ZYP and its prototype compounds and metabolites in rat biological samples, as well as ex...