Myocardial adaptation and exercise performance in patients with pulmonary arterial hypertension assessed with patient-specific computer simulations

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 321; no. 5; pp. H865 - H880
• Main Authors: Olsen, Niels Thue, Göransson, Christoffer, Vejlstrup, Niels, Carlsen, Jørn
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.11.2021
• Subjects: Adaptation; Cardiac output; Catheterization; Computer simulation; Heart; Hypertension; Magnetic properties; Magnetic resonance imaging; Mathematical models; Muscle contraction; Patients; Performance evaluation; Pulmonary hypertension; Simulation; Ventricle

Computer simulations of the myocardial mechanics and hemodynamics of rest and exercise were performed in nine patients with pulmonary arterial hypertension and 10 control subjects, with the use of data from invasive catheterization and from cardiac magnetic resonance. This approach allowed a detaile...