The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study

• Published in: Journal of affective disorders Vol. 129; no. 1-3; pp. 158 - 166
• Main Authors: ABERG, Elin, FANDINO-LOSADA, Andrés, SJÖHOLM, Louise K, FORSELL, Yvonne, LAVEBRATT, Catharina
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 01.03.2011
• Subjects: Adult; Adult and adolescent clinical studies; Alleles; Biological and medical sciences; Catechol O-Methyltransferase - genetics; Depression; Depressive Disorder - enzymology; Depressive Disorder - genetics; Depressive Disorder, Major - enzymology; Depressive Disorder, Major - genetics; Female; Genotype; Humans; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Mood disorders; Motivation - genetics; Polymorphism, Single Nucleotide - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk Factors; Sex Factors; Sweden - epidemiology; Sweden; Affect affectivity; Mood level and motivation state; Gene interaction; Central nervous system; Male; Population-based cohort; Catechol O-methyltransferase; Genetic determinism; Encephalon; Gender dimorphism; Childhood problems; Motivation; Population-based survey; Genetics; Sexual dimorphism; Child; Public health; Mood disorder; Human; Enzyme; Transferases; Depression; Mood; The brain reward system; Methyltransferases; Reward; Gene-environmental interactions; Polymorphism

Environmental risk factors together with genetic vulnerability create a complex background to develop depression. We investigated the associations between COMT Val(158)Met and depression in a Swedish population-based sample of 405 depressed individuals (major depression diagnosis, dysthymia or mixed...