Effectiveness and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: Protocol for systematic review and meta-analysis
Previous reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty. The study results published in the past 8 years may change this situation, but there is no updated systematic review. Therefore, we designed this study t...
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| Published in | Medicine (Baltimore) Vol. 99; no. 25; p. e20699 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Wolters Kluwer Health
19.06.2020
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| Abstract | Previous reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty. The study results published in the past 8 years may change this situation, but there is no updated systematic review. Therefore, we designed this study to systematically evaluate the effectiveness and safety of TCM in the treatment of NAFLD.
We will search nine online databases from inception to October 01 2019, and the language will not be restricted on included trials. Randomized controlled trials that included patients with NAFLD receiving TCM therapy versus a control group will be included. Two researcher will perform independently the selection of studies, risk of bias assessment and data extraction. We will use the RevMan V.5.2 software with fixed effects model or random effects model according to the heterogeneity test to conduct the data synthesis. We will present the dichotomous data and the continuous data with risk ratios with 95% CIs and weighted mean differences or standardized mean differences with 95% CIs. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system will be used to evaluate the evidence quality with low risk, unclear risk, and high risk.
This study will demonstrate an evidence-based review of TCM for NAFLD.
The study will provide clear evidence to assess the effectiveness and side effects of TCM for NAFLD. |
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| AbstractList | Previous reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty. The study results published in the past 8 years may change this situation, but there is no updated systematic review. Therefore, we designed this study to systematically evaluate the effectiveness and safety of TCM in the treatment of NAFLD.
We will search nine online databases from inception to October 01 2019, and the language will not be restricted on included trials. Randomized controlled trials that included patients with NAFLD receiving TCM therapy versus a control group will be included. Two researcher will perform independently the selection of studies, risk of bias assessment and data extraction. We will use the RevMan V.5.2 software with fixed effects model or random effects model according to the heterogeneity test to conduct the data synthesis. We will present the dichotomous data and the continuous data with risk ratios with 95% CIs and weighted mean differences or standardized mean differences with 95% CIs. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system will be used to evaluate the evidence quality with low risk, unclear risk, and high risk.
This study will demonstrate an evidence-based review of TCM for NAFLD.
The study will provide clear evidence to assess the effectiveness and side effects of TCM for NAFLD. BACKGROUNDPrevious reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty. The study results published in the past 8 years may change this situation, but there is no updated systematic review. Therefore, we designed this study to systematically evaluate the effectiveness and safety of TCM in the treatment of NAFLD.METHODS AND ANALYSISWe will search nine online databases from inception to October 01 2019, and the language will not be restricted on included trials. Randomized controlled trials that included patients with NAFLD receiving TCM therapy versus a control group will be included. Two researcher will perform independently the selection of studies, risk of bias assessment and data extraction. We will use the RevMan V.5.2 software with fixed effects model or random effects model according to the heterogeneity test to conduct the data synthesis. We will present the dichotomous data and the continuous data with risk ratios with 95% CIs and weighted mean differences or standardized mean differences with 95% CIs. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system will be used to evaluate the evidence quality with low risk, unclear risk, and high risk.RESULTSThis study will demonstrate an evidence-based review of TCM for NAFLD.CONCLUSIONThe study will provide clear evidence to assess the effectiveness and side effects of TCM for NAFLD. Supplemental Digital Content is available in the text |
| Author | Chi, Zhenhai Qin, Manman Ren, Jiankun Yuan, Fuqiang |
| AuthorAffiliation | a Jiangxi University of Traditional Chinese Medicine, Wanli District, Nanchang, Jiangxi b Henan Vocational College of Nursing, Anyang, Henan c Department of Acupuncture-Moxibustion, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi China |
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| Cites_doi | 10.1007/s11033-012-1836-0 10.1038/nrgastro.2013.183 10.1038/nrd.2016.188 10.1186/2046-4053-4-1 10.1016/j.jhep.2017.06.003 10.1038/nrgastro.2013.149 10.1111/liv.13302 10.1053/j.gastro.2015.04.005 10.1016/j.ctcp.2018.10.006 10.1002/hep.22044 10.1136/bmj.d5928 10.1016/j.jclinepi.2010.09.011 10.1016/S0140-6736(14)61933-4 10.1007/s00535-017-1415-1 10.1007/s10620-015-3728-3 10.14218/JCTH.2017.00056 10.1136/bmj.39489.470347.AD 10.1038/nrgastro.2017.109 |
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| Snippet | Previous reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty. The study... BACKGROUNDPrevious reviews indicate that the effect of Traditional Chinese medicines (TCM) on non-alcoholic fatty liver disease (NAFLD) remains uncertainty.... Supplemental Digital Content is available in the text |
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| SubjectTerms | Humans Medicine, Chinese Traditional - methods Meta-Analysis as Topic Non-alcoholic Fatty Liver Disease - therapy Study Protocol Systematic Review Systematic Reviews as Topic |
| Title | Effectiveness and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: Protocol for systematic review and meta-analysis |
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