3-(4-Fluorophenyl)-1-(1-(4-fluorophenyl)-3,3,3-trifluoroprop-1-en-1-yl)-5-fluoro-1H-pyrazole

• Published in: MolBank Vol. 2023; no. 2; p. M1620
• Main Authors: Paveliev, Stanislav, Ustyuzhanin, Alexander, Krylov, Igor, Terent’ev, Alexander
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2023
• Subjects: Carbon nitride; Catalysis; Chromatography; Conflicts of interest; Fluorine; free radicals; Infrared spectroscopy; Ions; Light; Mass spectrometry; NMR; Nuclear magnetic resonance; Pharmaceutical industry; Pharmaceutical sciences; Photocatalysis; photoredox catalysis; Pyrazole; pyrazoles; Scientific imaging; Synthesis; trifluoromethylation; United States > US

In this work, the title compound was synthesized via the visible-light-induced radical denitrogenative trifluoromethylation of the corresponding vinyl azide followed by Cs2CO3-mediated defluorinative cyclization of the resultant azine. The widely available sodium trifluoromethanesulfinate is used as...