Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

• Published in: Future journal of pharmaceutical sciences Vol. 10; no. 1; pp. 50 - 9
• Main Authors: Mahajan, Bhavna Sunil, Kawale, Laxman A., Nade, Vandana S., Unavane, Supriya, Sajimon, Lida, Kapadnis, Prajakta
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 29.03.2024; Springer Nature B.V; SpringerOpen
• Subjects: Anti-anxiety agents; Antifungal agents; Anxiety; Benzimidazole derivatives; Benzodiazepines; Biological activity; Chromatography; Docking; Elevated Plus Maze (EPM) test; Hole board test; Ligands; Mass spectrometry; Medicine; Medicine & Public Health; NMR; Nuclear magnetic resonance; Piperazines; Proteins; Scientific imaging; Software; Statistical analysis; Well being; Piperazines; Benzimidazole derivatives; Anti-anxiety agents; Docking; Health and well-being; Elevated Plus Maze (EPM) test; Hole board test

Background In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states. Extensive literature reviews indicate the diverse biological effects of benzimidazole and piperazine derivatives, notably their impact on the central nervo...