Multiparameter flow cytometric analysis of neoplasms of the central nervous system: correlation of nuclear antigen p105 and DNA content with clinical behavior

• Published in: Neurosurgery Vol. 27; no. 1; p. 83
• Main Authors: Appley, A J, Fitzgibbons, P L, Chandrasoma, P T, Hinton, D R, Apuzzo, M L
• Format: Journal Article
• Language: English
• Published: United States 01.07.1990
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Nuclear; Brain Neoplasms - analysis; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Child; Child, Preschool; DNA, Neoplasm - analysis; Female; Flow Cytometry - methods; Glioma - analysis; Glioma - genetics; Glioma - mortality; Humans; Male; Meningeal Neoplasms - analysis; Meningeal Neoplasms - genetics; Meningeal Neoplasms - mortality; Meningioma - analysis; Meningioma - genetics; Meningioma - mortality; Middle Aged; Nuclear Proteins - analysis; Prognosis

Analysis of the DNA content of various solid tumors and hematological malignancies may provide useful prognostic information. To date, however, there has been a striking lack of correlation between DNA content in neoplasms of the central nervous system and clinical behavior. Simultaneous quantitatio...