Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness
Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field...
Saved in:
Published in | International journal of molecular sciences Vol. 25; no. 17; p. 9407 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
29.08.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field. The substantial progress made over the last decade has revealed genes, signalling pathways, molecules, and neuronal networks in pain control thus opening new clinical perspectives in pain management. In this respect, data on the epigenetic modulation of opioid and cannabinoid receptors, key actors in the modulation of pain, offered new perspectives to preserve the activity of opioid and endocannabinoid systems to increase the analgesic efficacy of opioid- and cannabinoid-based drugs. Similarly, upcoming data on cannabidiol (CBD), a non-psychoactive cannabinoid in the marijuana plant
, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant and ansiolitic effects and supports its potential application in clinical contexts such as cancer, neurodegeneration, and autoimmune diseases but also in health and fitness with potential use in athletes. Hence, in this review article, we summarize the emerging epigenetic modifications of opioid and cannabinoid receptors and focus on CBD as an emerging non-psychoactive cannabinoid in pain management in clinical practice, health, and fitness. |
---|---|
AbstractList | Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field. The substantial progress made over the last decade has revealed genes, signalling pathways, molecules, and neuronal networks in pain control thus opening new clinical perspectives in pain management. In this respect, data on the epigenetic modulation of opioid and cannabinoid receptors, key actors in the modulation of pain, offered new perspectives to preserve the activity of opioid and endocannabinoid systems to increase the analgesic efficacy of opioid- and cannabinoid-based drugs. Similarly, upcoming data on cannabidiol (CBD), a non-psychoactive cannabinoid in the marijuana plant Cannabis sativa, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant and ansiolitic effects and supports its potential application in clinical contexts such as cancer, neurodegeneration, and autoimmune diseases but also in health and fitness with potential use in athletes. Hence, in this review article, we summarize the emerging epigenetic modifications of opioid and cannabinoid receptors and focus on CBD as an emerging non-psychoactive cannabinoid in pain management in clinical practice, health, and fitness.Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field. The substantial progress made over the last decade has revealed genes, signalling pathways, molecules, and neuronal networks in pain control thus opening new clinical perspectives in pain management. In this respect, data on the epigenetic modulation of opioid and cannabinoid receptors, key actors in the modulation of pain, offered new perspectives to preserve the activity of opioid and endocannabinoid systems to increase the analgesic efficacy of opioid- and cannabinoid-based drugs. Similarly, upcoming data on cannabidiol (CBD), a non-psychoactive cannabinoid in the marijuana plant Cannabis sativa, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant and ansiolitic effects and supports its potential application in clinical contexts such as cancer, neurodegeneration, and autoimmune diseases but also in health and fitness with potential use in athletes. Hence, in this review article, we summarize the emerging epigenetic modifications of opioid and cannabinoid receptors and focus on CBD as an emerging non-psychoactive cannabinoid in pain management in clinical practice, health, and fitness. Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field. The substantial progress made over the last decade has revealed genes, signalling pathways, molecules, and neuronal networks in pain control thus opening new clinical perspectives in pain management. In this respect, data on the epigenetic modulation of opioid and cannabinoid receptors, key actors in the modulation of pain, offered new perspectives to preserve the activity of opioid and endocannabinoid systems to increase the analgesic efficacy of opioid- and cannabinoid-based drugs. Similarly, upcoming data on cannabidiol (CBD), a non-psychoactive cannabinoid in the marijuana plant Cannabis sativa, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant and ansiolitic effects and supports its potential application in clinical contexts such as cancer, neurodegeneration, and autoimmune diseases but also in health and fitness with potential use in athletes. Hence, in this review article, we summarize the emerging epigenetic modifications of opioid and cannabinoid receptors and focus on CBD as an emerging non-psychoactive cannabinoid in pain management in clinical practice, health, and fitness. Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies in the field. The substantial progress made over the last decade has revealed genes, signalling pathways, molecules, and neuronal networks in pain control thus opening new clinical perspectives in pain management. In this respect, data on the epigenetic modulation of opioid and cannabinoid receptors, key actors in the modulation of pain, offered new perspectives to preserve the activity of opioid and endocannabinoid systems to increase the analgesic efficacy of opioid- and cannabinoid-based drugs. Similarly, upcoming data on cannabidiol (CBD), a non-psychoactive cannabinoid in the marijuana plant , suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant and ansiolitic effects and supports its potential application in clinical contexts such as cancer, neurodegeneration, and autoimmune diseases but also in health and fitness with potential use in athletes. Hence, in this review article, we summarize the emerging epigenetic modifications of opioid and cannabinoid receptors and focus on CBD as an emerging non-psychoactive cannabinoid in pain management in clinical practice, health, and fitness. |
Author | Pastorino, Grazia Maria Giovanna Secondulfo, Carmine Mazzeo, Filomena Operto, Francesca Felicia Vicidomini, Antonella Meccariello, Rosaria |
Author_xml | – sequence: 1 givenname: Carmine orcidid: 0000-0003-2742-237X surname: Secondulfo fullname: Secondulfo, Carmine organization: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy – sequence: 2 givenname: Filomena orcidid: 0000-0002-5217-4710 surname: Mazzeo fullname: Mazzeo, Filomena organization: Department of Economics, Law, Cybersecurity and Sports Sciences, University of Naples Parthenope, 80035 Nola, Italy – sequence: 3 givenname: Grazia Maria Giovanna orcidid: 0000-0003-0404-5495 surname: Pastorino fullname: Pastorino, Grazia Maria Giovanna organization: Child and Adolescent Neuropsychiatry Unit, "San Giovanni di Dio e Ruggi d'Aragona" Hospital, 84131 Salerno, Italy – sequence: 4 givenname: Antonella surname: Vicidomini fullname: Vicidomini, Antonella organization: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy – sequence: 5 givenname: Rosaria orcidid: 0000-0003-2174-1118 surname: Meccariello fullname: Meccariello, Rosaria organization: Department of Medical, Human Movement and Well-Being Sciences, University of Naples Parthenope, 80133 Naples, Italy – sequence: 6 givenname: Francesca Felicia orcidid: 0000-0002-2444-8761 surname: Operto fullname: Operto, Francesca Felicia organization: Department of Science of Health, School of Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39273354$$D View this record in MEDLINE/PubMed |
BookMark | eNpd0UtrGzEUBWARUvJqdlkXQTdd2K1Gj9Gou2CSJpCQQJv1cCVdOzIzkivNUPLvO7bTELrSg0-HK84pOYwpIiEXFfsqhGHfwrovXFXaSKYPyEklOZ8zVuvDd_tjclrKmjEuuDJH5FgYroVQ8oT8ediEFDyF6OkCYgQb4vb886UM2BcaIn2EEL_Tqx7zKsQVvU8durGDTO_RPUMMZWLb508Ft3zRhRgcdPQxgxuCwxm9QeiG59lOXYchYikfyYcldAXPX9cz8nR99WtxM797-HG7uLybO1GxYS6Z0lpZLgUw1ygwyirvLAeDsrZeGweW1UpwZtFzj2gVMilNYxSDpubijNzuc32CdbvJoYf80iYI7e4i5VULeZqyw7ZpNNNOLblBJRtnALyWUGFTec2Vginryz5rk9PvEcvQ9qE47DqImMbSThNLJRmvxUQ__0fXacxx-ulOVayZ2prUbK9cTqVkXL4NWLF2W277vtyJf3oNHW2P_g3_a1P8BTjtn7g |
Cites_doi | 10.31887/DCNS.2020.22.3/rspanagel 10.1016/j.pmn.2023.10.002 10.6064/2012/561761 10.3389/fgene.2012.00110 10.1126/science.aai8636 10.3389/fphys.2021.722550 10.1016/S0304-3959(98)00184-5 10.1016/0306-4522(93)90323-8 10.1080/00325481.2019.1685298 10.1016/j.phrs.2021.105662 10.1097/00000658-194601000-00008 10.1097/j.pain.0000000000002268 10.1038/s41583-018-0028-x 10.1016/j.jmig.2021.11.017 10.1002/(SICI)1096-9861(19990315)405:3<359::AID-CNE6>3.0.CO;2-W 10.1111/jphp.13135 10.1097/j.pain.0000000000000894 10.26773/smj.181020 10.1146/annurev-pharmtox-010617-052554 10.1016/S0304-3959(99)00012-3 10.14740/jocmr4090 10.1016/j.neuron.2007.07.016 10.1016/j.jpain.2017.04.001 10.1084/jem.187.3.297 10.26773/smj.190212 10.36076/ppj.2012/15/ES205 10.1080/14659891.2019.1642410 10.1046/j.0953-816x.2001.01760.x 10.1016/j.jbc.2022.101999 10.3390/ijms21031113 10.1016/j.expneurol.2020.113572 10.3171/jns.1962.19.2.0089 10.1126/science.3016896 10.1155/2018/1691428 10.1249/MSS.0000000000002606 10.1016/j.plipres.2023.101239 10.1007/s00213-020-05712-8 10.1146/annurev.neuro.051508.135531 10.1038/s41582-019-0284-z 10.3390/ijms241612760 10.1523/JNEUROSCI.2616-17.2018 10.1016/S0304-3959(99)00139-6 10.1007/978-1-4939-1708-2_3 10.3390/cells12232672 10.1113/jphysiol.1996.sp021152 10.1021/acschemneuro.1c00841 10.1111/j.1365-2826.2008.01671.x 10.1074/jbc.RA119.011053 10.1007/978-981-15-3449-2_1 10.1016/S0014-827X(98)00109-8 10.1097/j.pain.0000000000000831 10.1007/s11916-023-01101-w 10.1186/s42238-022-00154-9 10.1016/j.jpain.2009.06.012 10.1097/PR9.0000000000000850 10.1016/0166-2236(93)90092-Z 10.1172/JCI42843 10.1159/000101296 10.1002/iub.1264 10.1007/s11916-020-0835-4 10.1155/2023/8824466 10.1016/j.neuroscience.2016.09.015 10.1007/BF02853167 10.2165/00007256-198401020-00004 10.1177/15353702231162086 10.1080/13543784.2018.1516204 10.1186/s40798-020-00251-0 10.1016/0304-3959(79)90049-6 10.1017/neu.2018.11 10.3390/nu15122664 10.1097/j.pain.0000000000000428 10.1111/bph.14382 10.1002/biof.1158 10.1007/s11926-022-01077-3 10.3389/fpsyt.2020.623672 10.1016/j.peptides.2016.12.004 10.3390/ijms22020972 10.1016/j.bbr.2023.114592 10.1186/1744-8069-7-20 10.1371/journal.pone.0142046 10.3390/nu13093028 10.1016/0304-3959(79)90050-2 10.3390/ph16020155 10.1016/S0079-6123(03)46023-8 10.1016/j.jchemneu.2011.11.002 10.1080/14728222.2017.1328057 10.1523/JNEUROSCI.0880-18.2018 10.1038/nn966 10.1016/j.pain.2008.09.009 10.3389/fnins.2019.01097 10.3390/ijms24032348 10.1074/jbc.M115.711812 10.1016/j.brainresrev.2008.12.009 10.1007/s40263-021-00879-w 10.1124/mol.118.114637 10.1080/09540260902782794 10.3390/ijms19030833 10.1038/scientificamerican0606-60 10.1080/15592294.2015.1006493 10.1111/j.1533-2500.2012.00578.x 10.1016/j.cell.2009.09.028 10.1038/383819a0 10.1038/76061 10.3109/00952990.2010.535581 10.15280/jlm.2022.12.1.9 10.1186/s13102-022-00397-2 10.1016/S0301-0082(01)00025-9 10.1007/s10072-020-04514-2 10.1523/JNEUROSCI.5541-09.2010 10.1007/s40279-021-01505-x 10.1002/ejp.1147 10.3389/fncel.2023.1328269 10.3390/ijms24097831 10.3389/fphar.2018.01388 10.1038/nrd.2017.87 10.1007/s11916-023-01144-z 10.1007/s40263-019-00660-0 10.1016/S0165-0173(02)00186-8 10.1083/jcb.104.6.1623 10.1213/ANE.0000000000006584 10.1016/j.neuropharm.2023.109597 10.2174/1570159X15666171017102547 10.36076/ppj.20.5.E755 10.1080/15502783.2023.2280113 10.1089/can.2023.0012 |
ContentType | Journal Article |
Copyright | 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 DOA |
DOI | 10.3390/ijms25179407 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database Research Library Research Library (Corporate) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef MEDLINE |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1422-0067 |
ExternalDocumentID | oai_doaj_org_article_88707c5f29e548c9aad74a1e81d7255a 10_3390_ijms25179407 39273354 |
Genre | Journal Article Review |
GroupedDBID | --- 29J 2WC 3V. 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH ABDBF ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D1I DIK DU5 DWQXO E3Z EBD EBS ECM EIF EJD ESTFP ESX F5P FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HH5 HMCUK HYE IAO ITC KB. KQ8 LK8 M1P M2O M48 M7P MODMG M~E NPM O5R O5S OK1 P2P PDBOC PIMPY PQQKQ PROAC PSQYO RIG RNS RPM TR2 TUS UKHRP ~8M AAYXX AFPKN CITATION 7XB 8FK K9. MBDVC PQEST PQUKI PRINS Q9U 7X8 |
ID | FETCH-LOGICAL-c310t-405775b243a0c85a95b5dcb2a9e46bd79cab065320bed2deeb5e04498950a8623 |
IEDL.DBID | M48 |
ISSN | 1422-0067 1661-6596 |
IngestDate | Tue Oct 22 15:13:04 EDT 2024 Mon Sep 16 17:10:54 EDT 2024 Thu Oct 10 21:49:56 EDT 2024 Thu Sep 26 20:33:03 EDT 2024 Wed Oct 23 09:43:50 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 17 |
Keywords | pain CB1 CBD Oprm1 cannabinoids clinical practice health and fitness epigenetics opioids |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c310t-405775b243a0c85a95b5dcb2a9e46bd79cab065320bed2deeb5e04498950a8623 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
ORCID | 0000-0003-0404-5495 0000-0002-5217-4710 0000-0003-2174-1118 0000-0003-2742-237X 0000-0002-2444-8761 |
OpenAccessLink | https://www.proquest.com/docview/3104108407?pq-origsite=%requestingapplication% |
PMID | 39273354 |
PQID | 3104108407 |
PQPubID | 2032341 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_88707c5f29e548c9aad74a1e81d7255a proquest_miscellaneous_3104540263 proquest_journals_3104108407 crossref_primary_10_3390_ijms25179407 pubmed_primary_39273354 |
PublicationCentury | 2000 |
PublicationDate | 2024-Aug-29 |
PublicationDateYYYYMMDD | 2024-08-29 |
PublicationDate_xml | – month: 08 year: 2024 text: 2024-Aug-29 day: 29 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland – name: Basel |
PublicationTitle | International journal of molecular sciences |
PublicationTitleAlternate | Int J Mol Sci |
PublicationYear | 2024 |
Publisher | MDPI AG |
Publisher_xml | – name: MDPI AG |
References | ref_137 ref_93 ref_92 ref_91 Lu (ref_71) 2021; 6 Kawamoto (ref_26) 2004; 146 Burr (ref_133) 2021; 51 Odeh (ref_47) 2001; 14 Maldonado (ref_103) 2016; 157 ref_12 Costigan (ref_24) 2009; 32 Oliveira (ref_77) 2019; 31 ref_99 ref_97 ref_132 Beecher (ref_39) 1946; 123 Chen (ref_94) 2023; 452 Mackie (ref_68) 2008; 20 ref_19 ref_18 Tao (ref_86) 2016; 339 Kanwar (ref_82) 2015; 10 Peters (ref_127) 2023; 20 ref_15 McCartney (ref_17) 2020; 6 Garriga (ref_83) 2018; 38 Britch (ref_139) 2021; 238 Pereira (ref_44) 2007; 85 Almeida (ref_55) 1993; 55 Santos (ref_131) 2023; 248 Aviram (ref_107) 2017; 20 Osborne (ref_48) 1996; 490 Mohammed (ref_104) 2024; 25 Nijs (ref_125) 2012; 15 Luo (ref_89) 2020; 295 Testa (ref_31) 2021; 169 Mo (ref_84) 2018; 38 Boyaji (ref_138) 2020; 24 Morgan (ref_49) 2008; 140 Cristino (ref_74) 2020; 16 Finn (ref_7) 2021; 162 Zhang (ref_81) 2014; 66 Frane (ref_111) 2022; 4 Heinricher (ref_45) 2009; 60 (ref_56) 2002; 40 Bodnar (ref_59) 2017; 88 ref_78 ref_76 Zhang (ref_80) 2020; 1253 Oddi (ref_72) 2023; 91 Iyengar (ref_33) 2017; 158 Kapoor (ref_116) 2022; 12 Matthes (ref_62) 1996; 383 Viet (ref_90) 2017; 18 Stein (ref_63) 2018; 27 Fields (ref_3) 1999; 82 Antunes (ref_130) 2022; 37 Chandwani (ref_113) 2023; 27 Treede (ref_40) 1999; 79 Chianese (ref_75) 2018; 16 ref_87 Kleberg (ref_70) 2014; 40 Lesnak (ref_117) 2020; 5 Basbaum (ref_23) 2009; 139 Zheng (ref_13) 2021; 337 Larsen (ref_101) 2020; 12 Hearon (ref_120) 2011; 37 Zhang (ref_88) 2016; 291 Petzke (ref_109) 2022; 36 Mazzeo (ref_124) 2018; 13 Mazzeo (ref_136) 2019; 24 Ochandarena (ref_5) 2023; 238 Ross (ref_135) 2023; 2023 Dickenson (ref_51) 1979; 6 (ref_73) 2019; 176 Ruscheweyh (ref_38) 2011; 7 Mistry (ref_112) 2022; 29 Aicher (ref_50) 2012; 43 Ploner (ref_41) 1999; 81 Hwang (ref_85) 2015; 1230 Matsuda (ref_27) 1998; 187 Fiani (ref_114) 2020; 41 Uchida (ref_95) 2010; 30 Ossipov (ref_2) 2012; 2012 Adarsh (ref_6) 2020; 12 Sexton (ref_21) 2018; 58 Zvonarev (ref_11) 2019; 11 Bajic (ref_46) 1999; 405 Mazzeo (ref_121) 2019; 17 ref_69 Mazzeo (ref_122) 2016; 9 ref_67 Aguiar (ref_134) 2023; 8 ref_66 Latremoliere (ref_37) 2009; 10 Filliol (ref_61) 2000; 25 Woolf (ref_34) 2007; 55 Motola (ref_129) 2001; 18 Phillips (ref_108) 2018; 3 Suzuki (ref_36) 2003; 5 Dickenson (ref_52) 1979; 6 Darcq (ref_58) 2018; 19 Pfeiffer (ref_60) 1986; 233 Sideris (ref_98) 2024; 138 ref_115 Mercadante (ref_8) 2019; 33 Ghosh (ref_14) 2022; 13 Tsou (ref_43) 1964; 13 Hameed (ref_105) 2023; 27 ref_119 Mazzeo (ref_126) 2018; 16 Basbaum (ref_35) 2006; 294 Spanagel (ref_10) 2020; 22 Lima (ref_54) 2002; 66 ref_32 ref_30 Wells (ref_102) 2018; 22 Lewin (ref_29) 1993; 16 Harber (ref_118) 1984; 1 Villanueva (ref_53) 1995; 28 Foltz (ref_42) 1962; 19 Boehnke (ref_110) 2022; 24 Sun (ref_96) 2017; 158 Capano (ref_106) 2020; 132 Wang (ref_79) 2019; 71 Villanueva (ref_16) 2022; 14 Dubin (ref_22) 2010; 120 ref_100 Spahn (ref_65) 2017; 355 Berta (ref_20) 2017; 21 Bruno (ref_25) 1999; 54 ref_1 Heumann (ref_28) 1987; 104 Jeske (ref_57) 2019; 95 Pergolizzi (ref_123) 2013; 13 Welch (ref_4) 2009; 21 ref_9 Yekkirala (ref_64) 2017; 16 Cruz (ref_128) 2021; 53 |
References_xml | – volume: 22 start-page: 241 year: 2020 ident: ref_10 article-title: Cannabinoids and the endocannabinoid system in reward processing and addiction: From mechanisms to interventions publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2020.22.3/rspanagel contributor: fullname: Spanagel – volume: 25 start-page: e76 year: 2024 ident: ref_104 article-title: Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review publication-title: Pain Manag. Nurs. doi: 10.1016/j.pmn.2023.10.002 contributor: fullname: Mohammed – volume: 2012 start-page: 561761 year: 2012 ident: ref_2 article-title: The Perception and Endogenous Modulation of Pain publication-title: Scientifica doi: 10.6064/2012/561761 contributor: fullname: Ossipov – ident: ref_93 doi: 10.3389/fgene.2012.00110 – ident: ref_100 – volume: 355 start-page: 966 year: 2017 ident: ref_65 article-title: A nontoxic pain killer designed by modeling of pathological receptor conformations publication-title: Science doi: 10.1126/science.aai8636 contributor: fullname: Spahn – ident: ref_18 doi: 10.3389/fphys.2021.722550 – volume: 79 start-page: 105 year: 1999 ident: ref_40 article-title: The cortical representation of pain publication-title: Pain doi: 10.1016/S0304-3959(98)00184-5 contributor: fullname: Treede – volume: 55 start-page: 1093 year: 1993 ident: ref_55 article-title: Descending projections from the medullary dorsal reticular nucleus make synaptic contacts with spinal cord lamina I cells projecting to that nucleus: An electron microscopic tracer study in the rat publication-title: Neuroscience doi: 10.1016/0306-4522(93)90323-8 contributor: fullname: Almeida – volume: 132 start-page: 56 year: 2020 ident: ref_106 article-title: Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: A prospective cohort study publication-title: Postgrad. Med. doi: 10.1080/00325481.2019.1685298 contributor: fullname: Capano – volume: 169 start-page: 105662 year: 2021 ident: ref_31 article-title: Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2021.105662 contributor: fullname: Testa – ident: ref_1 – volume: 123 start-page: 96 year: 1946 ident: ref_39 article-title: Pain in Men Wounded in Battle publication-title: Ann. Surg. doi: 10.1097/00000658-194601000-00008 contributor: fullname: Beecher – volume: 162 start-page: S5 year: 2021 ident: ref_7 article-title: Cannabinoids, the endocannabinoid system, and pain: A review of preclinical studies publication-title: Pain doi: 10.1097/j.pain.0000000000002268 contributor: fullname: Finn – volume: 19 start-page: 499 year: 2018 ident: ref_58 article-title: Opioid receptors: Drivers to addiction? publication-title: Nat. Rev. Neurosci. doi: 10.1038/s41583-018-0028-x contributor: fullname: Darcq – volume: 29 start-page: 169 year: 2022 ident: ref_112 article-title: Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain publication-title: J. Minim. Invasive Gynecol. doi: 10.1016/j.jmig.2021.11.017 contributor: fullname: Mistry – volume: 405 start-page: 359 year: 1999 ident: ref_46 article-title: Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception publication-title: J. Comp. Neurol. doi: 10.1002/(SICI)1096-9861(19990315)405:3<359::AID-CNE6>3.0.CO;2-W contributor: fullname: Bajic – volume: 71 start-page: 1469 year: 2019 ident: ref_79 article-title: Cannabinoid receptors in osteoporosis and osteoporotic pain: A narrative update of review publication-title: J. Pharm. Pharmacol. doi: 10.1111/jphp.13135 contributor: fullname: Wang – volume: 158 start-page: 1153 year: 2017 ident: ref_96 article-title: Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons publication-title: Pain doi: 10.1097/j.pain.0000000000000894 contributor: fullname: Sun – volume: 16 start-page: 113 year: 2018 ident: ref_126 article-title: Anabolic steroid use in sports and in physical activity: Overview and analysis publication-title: Sport Mont. doi: 10.26773/smj.181020 contributor: fullname: Mazzeo – volume: 58 start-page: 123 year: 2018 ident: ref_21 article-title: The Genetics of Pain: Implications for Therapeutics publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-010617-052554 contributor: fullname: Sexton – volume: 81 start-page: 211 year: 1999 ident: ref_41 article-title: Pain affect without pain sensation in a patient with a postcentral lesion publication-title: Pain doi: 10.1016/S0304-3959(99)00012-3 contributor: fullname: Ploner – volume: 12 start-page: 129 year: 2020 ident: ref_101 article-title: Dosage, efficacy and safety of cannabidiol administration in adults: A systematic review of human trials publication-title: J. Clin. Med. Res. doi: 10.14740/jocmr4090 contributor: fullname: Larsen – volume: 55 start-page: 353 year: 2007 ident: ref_34 article-title: Nociceptors--noxious stimulus detectors publication-title: Neuron doi: 10.1016/j.neuron.2007.07.016 contributor: fullname: Woolf – volume: 18 start-page: 1046 year: 2017 ident: ref_90 article-title: OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients publication-title: J. Pain doi: 10.1016/j.jpain.2017.04.001 contributor: fullname: Viet – volume: 187 start-page: 297 year: 1998 ident: ref_27 article-title: Role of nerve growth factor in cutaneous wound healing: Accelerating effects in normal and healing-impaired diabetic mice publication-title: J. Exp. Med. doi: 10.1084/jem.187.3.297 contributor: fullname: Matsuda – volume: 17 start-page: 69 year: 2019 ident: ref_121 article-title: Gender difference, nutritional supplements and drug use in sport to enhancing performance: An Italian revision over the last decade publication-title: Sport Mont. doi: 10.26773/smj.190212 contributor: fullname: Mazzeo – volume: 15 start-page: ES205 year: 2012 ident: ref_125 article-title: Dysfunctional endogenous analgesia during exercise in patients with chronic pain: To exercise or not to exercise? publication-title: Pain Physician doi: 10.36076/ppj.2012/15/ES205 contributor: fullname: Nijs – volume: 24 start-page: 581 year: 2019 ident: ref_136 article-title: Attitude and practice of substance misuse and dietary supplements to improve performance in sport publication-title: J. Sub. Use doi: 10.1080/14659891.2019.1642410 contributor: fullname: Mazzeo – volume: 14 start-page: 1275 year: 2001 ident: ref_47 article-title: The projections of the midbrain periaqueductal grey to the pons and medulla oblongata in rats publication-title: Eur. J. Neurosci. doi: 10.1046/j.0953-816x.2001.01760.x contributor: fullname: Odeh – ident: ref_97 doi: 10.1016/j.jbc.2022.101999 – ident: ref_12 doi: 10.3390/ijms21031113 – volume: 337 start-page: 113572 year: 2021 ident: ref_13 article-title: Nerve trauma-caused downregulation of opioid receptors in primary afferent neurons: Molecular mechanisms and potential managements publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2020.113572 contributor: fullname: Zheng – volume: 19 start-page: 89 year: 1962 ident: ref_42 article-title: Pain ‘relief’ by frontal cingulumotomy publication-title: J. Neurosurg. doi: 10.3171/jns.1962.19.2.0089 contributor: fullname: Foltz – volume: 233 start-page: 774 year: 1986 ident: ref_60 article-title: Psychotomimesis mediated by kappa opiate receptors publication-title: Science doi: 10.1126/science.3016896 contributor: fullname: Pfeiffer – ident: ref_30 – ident: ref_99 doi: 10.1155/2018/1691428 – volume: 53 start-page: 1460 year: 2021 ident: ref_128 article-title: The effects of cannabidiol oil on noninvasive measures of muscle damage in men publication-title: Med. Sci. Sport Exerc. doi: 10.1249/MSS.0000000000002606 contributor: fullname: Cruz – volume: 91 start-page: 101239 year: 2023 ident: ref_72 article-title: Endocannabinoid system and adult neurogenesis: A focused review publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2023.101239 contributor: fullname: Oddi – volume: 238 start-page: 9 year: 2021 ident: ref_139 article-title: Cannabidiol: Pharmacology and therapeutic targets publication-title: Psychopharmacology doi: 10.1007/s00213-020-05712-8 contributor: fullname: Britch – volume: 32 start-page: 1 year: 2009 ident: ref_24 article-title: Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage publication-title: Ann. Rev. Neurosci. doi: 10.1146/annurev.neuro.051508.135531 contributor: fullname: Costigan – volume: 11 start-page: e5806 year: 2019 ident: ref_11 article-title: The Public Health Concerns of Marijuana Legalization: An Overview of Current Trends publication-title: Cureus contributor: fullname: Zvonarev – volume: 16 start-page: 9 year: 2020 ident: ref_74 article-title: Cannabinoids and the expanded endocannabinoid system in neurological disorders publication-title: Nat. Rev. Neurol. doi: 10.1038/s41582-019-0284-z contributor: fullname: Cristino – ident: ref_67 doi: 10.3390/ijms241612760 – volume: 38 start-page: 6090 year: 2018 ident: ref_83 article-title: Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2616-17.2018 contributor: fullname: Garriga – volume: 82 start-page: S61 year: 1999 ident: ref_3 article-title: Pain: An unpleasant topic publication-title: Pain doi: 10.1016/S0304-3959(99)00139-6 contributor: fullname: Fields – volume: 1230 start-page: 39 year: 2015 ident: ref_85 article-title: Analysis of epigenetic mechanisms regulating opioid receptor gene transcription publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-1708-2_3 contributor: fullname: Hwang – ident: ref_115 doi: 10.3390/cells12232672 – volume: 490 start-page: 383 year: 1996 ident: ref_48 article-title: Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro publication-title: J. Physiol. doi: 10.1113/jphysiol.1996.sp021152 contributor: fullname: Osborne – volume: 13 start-page: 432 year: 2022 ident: ref_14 article-title: Epigenetic Mechanisms of Neural Plasticity in Chronic Neuropathic Pain publication-title: ACS Chem. Neurosci. doi: 10.1021/acschemneuro.1c00841 contributor: fullname: Ghosh – volume: 20 start-page: 10 year: 2008 ident: ref_68 article-title: Cannabinoid receptors: Where they are and what they do publication-title: J. Neuroendocrinol. doi: 10.1111/j.1365-2826.2008.01671.x contributor: fullname: Mackie – volume: 295 start-page: 3553 year: 2020 ident: ref_89 article-title: Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA119.011053 contributor: fullname: Luo – volume: 1253 start-page: 3 year: 2020 ident: ref_80 article-title: Epigenetics in Health and Disease publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-981-15-3449-2_1 contributor: fullname: Zhang – volume: 54 start-page: 95 year: 1999 ident: ref_25 article-title: Antiinflammatory agents: New series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity publication-title: Farmaco doi: 10.1016/S0014-827X(98)00109-8 contributor: fullname: Bruno – volume: 158 start-page: 543 year: 2017 ident: ref_33 article-title: The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine publication-title: Pain doi: 10.1097/j.pain.0000000000000831 contributor: fullname: Iyengar – volume: 27 start-page: 57 year: 2023 ident: ref_105 article-title: Medical Cannabis for Chronic Nonmalignant Pain Management publication-title: Curr. Pain Headache Rep. doi: 10.1007/s11916-023-01101-w contributor: fullname: Hameed – volume: 4 start-page: 47 year: 2022 ident: ref_111 article-title: Cannabidiol as a treatment for arthritis and joint pain: An exploratory cross-sectional study publication-title: J. Cannabis Res. doi: 10.1186/s42238-022-00154-9 contributor: fullname: Frane – volume: 14 start-page: e26913 year: 2022 ident: ref_16 article-title: Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A Systematic Review publication-title: Cureus contributor: fullname: Villanueva – volume: 10 start-page: 895 year: 2009 ident: ref_37 article-title: Central sensitization: A generator of pain hypersensitivity by central neural plasticity publication-title: J. Pain doi: 10.1016/j.jpain.2009.06.012 contributor: fullname: Latremoliere – volume: 5 start-page: e850 year: 2020 ident: ref_117 article-title: Mechanism of exercise-induced analgesia: What we can learn from physically active animals publication-title: Pain Rep. doi: 10.1097/PR9.0000000000000850 contributor: fullname: Lesnak – volume: 16 start-page: 353 year: 1993 ident: ref_29 article-title: Nerve growth factor and nociception publication-title: Trends Neurosci. doi: 10.1016/0166-2236(93)90092-Z contributor: fullname: Lewin – volume: 120 start-page: 3760 year: 2010 ident: ref_22 article-title: Nociceptors: The sensors of the pain pathway publication-title: J. Clin. Investig. doi: 10.1172/JCI42843 contributor: fullname: Dubin – volume: 85 start-page: 175 year: 2007 ident: ref_44 article-title: Regional cerebral perfusion differences between periventricular grey, thalamic and dual target deep brain stimulation for chronic neuropathic pain publication-title: Stereotact. Funct. Neurosurg. doi: 10.1159/000101296 contributor: fullname: Pereira – volume: 66 start-page: 240 year: 2014 ident: ref_81 article-title: Mammalian epigenetic mechanisms publication-title: IUBMB Life doi: 10.1002/iub.1264 contributor: fullname: Zhang – volume: 24 start-page: 4 year: 2020 ident: ref_138 article-title: The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence publication-title: Curr. Pain Headache Rep. doi: 10.1007/s11916-020-0835-4 contributor: fullname: Boyaji – volume: 2023 start-page: 8824466 year: 2023 ident: ref_135 article-title: Physician Perceptions of Cannabidiol (CBD) and Cannabis in Sports Medicine and Performance publication-title: Transl. Sports Med. doi: 10.1155/2023/8824466 contributor: fullname: Ross – volume: 339 start-page: 54 year: 2016 ident: ref_86 article-title: Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2016.09.015 contributor: fullname: Tao – volume: 18 start-page: 216 year: 2001 ident: ref_129 article-title: Over-the-counter oral nonsteroidal anti-inflammatory drugs: A pharmacoepidemiologic study in southern Italy publication-title: Adv. Ther. doi: 10.1007/BF02853167 contributor: fullname: Motola – ident: ref_32 – volume: 3 start-page: CD012182 year: 2018 ident: ref_108 article-title: Cannabis-based medicines for chronic neuropathic pain in adults publication-title: Cochrane Database Syst. Rev. contributor: fullname: Phillips – volume: 1 start-page: 154 year: 1984 ident: ref_118 article-title: Endorphins and exercise publication-title: Sports Med. doi: 10.2165/00007256-198401020-00004 contributor: fullname: Harber – volume: 248 start-page: 445 year: 2023 ident: ref_131 article-title: Cannabidiol for musculoskeletal regenerative medicine publication-title: Exp. Biol. Med. doi: 10.1177/15353702231162086 contributor: fullname: Santos – volume: 27 start-page: 765 year: 2018 ident: ref_63 article-title: New concepts in opioid analgesia publication-title: Expert Opin. Investig. Drugs doi: 10.1080/13543784.2018.1516204 contributor: fullname: Stein – volume: 6 start-page: 27 year: 2020 ident: ref_17 article-title: Cannabidiol and Sports Performance: A Narrative Review of Relevant Evidence and Recommendations for Future Research publication-title: Sports Med. Open doi: 10.1186/s40798-020-00251-0 contributor: fullname: McCartney – volume: 12 start-page: e10436 year: 2020 ident: ref_6 article-title: Cannabinoid Receptors and Their Relationship with Chronic Pain: A Narrative Review publication-title: Cureus contributor: fullname: Adarsh – volume: 6 start-page: 283 year: 1979 ident: ref_51 article-title: Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat publication-title: Pain doi: 10.1016/0304-3959(79)90049-6 contributor: fullname: Dickenson – volume: 31 start-page: 1 year: 2019 ident: ref_77 article-title: Cannabinoid signalling in embryonic and adult neurogenesis: Possible implications for psychiatric and neurological disorders publication-title: Acta Neuropsychiatr. doi: 10.1017/neu.2018.11 contributor: fullname: Oliveira – ident: ref_19 doi: 10.3390/nu15122664 – volume: 157 start-page: S23 year: 2016 ident: ref_103 article-title: The endocannabinoid system and neuropathic pain publication-title: Pain doi: 10.1097/j.pain.0000000000000428 contributor: fullname: Maldonado – volume: 176 start-page: 1370 year: 2019 ident: ref_73 article-title: The biomedical challenge of neurodegenerative disorders: An opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes publication-title: Br. J. Pharmacol. doi: 10.1111/bph.14382 – volume: 40 start-page: 363 year: 2014 ident: ref_70 article-title: Classical endocannabinoid-like compounds and their regulation by nutrients publication-title: Biofactors doi: 10.1002/biof.1158 contributor: fullname: Kleberg – volume: 24 start-page: 238 year: 2022 ident: ref_110 article-title: Cannabidiol (CBD) in Rheumatic Diseases (Musculoskeletal Pain) publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-022-01077-3 contributor: fullname: Boehnke – ident: ref_137 doi: 10.3389/fpsyt.2020.623672 – volume: 88 start-page: 126 year: 2017 ident: ref_59 article-title: Endogenous Opiates and Behavior: 2015 publication-title: Peptides doi: 10.1016/j.peptides.2016.12.004 contributor: fullname: Bodnar – ident: ref_76 doi: 10.3390/ijms22020972 – volume: 452 start-page: 114592 year: 2023 ident: ref_94 article-title: N6-Methyladenosine methylase METTL3 contributes to neuropathic pain by epigenetic silencing of mu opioid receptor publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2023.114592 contributor: fullname: Chen – volume: 7 start-page: 20 year: 2011 ident: ref_38 article-title: Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy publication-title: Mol. Pain doi: 10.1186/1744-8069-7-20 contributor: fullname: Ruscheweyh – volume: 13 start-page: 1099 year: 1964 ident: ref_43 article-title: Studies on the site of analgesic action of morphine by intracerebral micro-injection publication-title: Sci. Sin. contributor: fullname: Tsou – volume: 28 start-page: 113 year: 1995 ident: ref_53 article-title: The activation of bulbo-spinal controls by peripheral nociceptive inputs: Diffuse noxious inhibitory controls publication-title: Biol. Res. contributor: fullname: Villanueva – ident: ref_87 doi: 10.1371/journal.pone.0142046 – ident: ref_132 doi: 10.3390/nu13093028 – volume: 6 start-page: 305 year: 1979 ident: ref_52 article-title: Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications publication-title: Pain doi: 10.1016/0304-3959(79)90050-2 contributor: fullname: Dickenson – ident: ref_15 doi: 10.3390/ph16020155 – volume: 146 start-page: 369 year: 2004 ident: ref_26 article-title: Nerve growth factor and wound healing publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(03)46023-8 contributor: fullname: Kawamoto – volume: 43 start-page: 103 year: 2012 ident: ref_50 article-title: Descending projections from the rostral ventromedial medulla (RVM) to trigeminal and spinal dorsal horns are morphologically and neurochemically distinct publication-title: J. Chem. Neuroanat. doi: 10.1016/j.jchemneu.2011.11.002 contributor: fullname: Aicher – volume: 21 start-page: 695 year: 2017 ident: ref_20 article-title: Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain publication-title: Expert Opin. Ther. Targets doi: 10.1080/14728222.2017.1328057 contributor: fullname: Berta – volume: 38 start-page: 9883 year: 2018 ident: ref_84 article-title: MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0880-18.2018 contributor: fullname: Mo – volume: 5 start-page: 1319 year: 2003 ident: ref_36 article-title: Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways publication-title: Nat. Neurosci. doi: 10.1038/nn966 contributor: fullname: Suzuki – volume: 140 start-page: 376 year: 2008 ident: ref_49 article-title: Periaqueductal gray neurons project to spinally projecting GABAergic neurons in the rostral ventromedial medulla publication-title: Pain doi: 10.1016/j.pain.2008.09.009 contributor: fullname: Morgan – ident: ref_92 doi: 10.3389/fnins.2019.01097 – ident: ref_69 doi: 10.3390/ijms24032348 – volume: 291 start-page: 8475 year: 2016 ident: ref_88 article-title: Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.711812 contributor: fullname: Zhang – volume: 60 start-page: 214 year: 2009 ident: ref_45 article-title: Descending control of nociception: Specificity, recruitment and plasticity publication-title: Brain Res. Rev. doi: 10.1016/j.brainresrev.2008.12.009 contributor: fullname: Heinricher – volume: 36 start-page: 31 year: 2022 ident: ref_109 article-title: Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain publication-title: CNS Drugs doi: 10.1007/s40263-021-00879-w contributor: fullname: Petzke – volume: 95 start-page: 463 year: 2019 ident: ref_57 article-title: Dynamic Opioid Receptor Regulation in the Periphery publication-title: Mol. Pharmacol. doi: 10.1124/mol.118.114637 contributor: fullname: Jeske – volume: 21 start-page: 143 year: 2009 ident: ref_4 article-title: Interaction of the cannabinoid and opioid systems in the modulation of nociception publication-title: Int. Rev. Psychiatry doi: 10.1080/09540260902782794 contributor: fullname: Welch – ident: ref_78 doi: 10.3390/ijms19030833 – volume: 294 start-page: 60 year: 2006 ident: ref_35 article-title: Toward better pain control publication-title: Sci. Am. doi: 10.1038/scientificamerican0606-60 contributor: fullname: Basbaum – volume: 10 start-page: 200 year: 2015 ident: ref_82 article-title: Plasticity of DNA methylation in a nerve injury model of pain publication-title: Epigenetics doi: 10.1080/15592294.2015.1006493 contributor: fullname: Kanwar – volume: 13 start-page: 239 year: 2013 ident: ref_123 article-title: A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain publication-title: Pain Pract. doi: 10.1111/j.1533-2500.2012.00578.x contributor: fullname: Pergolizzi – volume: 139 start-page: 267 year: 2009 ident: ref_23 article-title: Cellular and Molecular Mechanisms of Pain publication-title: Cell doi: 10.1016/j.cell.2009.09.028 contributor: fullname: Basbaum – volume: 383 start-page: 819 year: 1996 ident: ref_62 article-title: Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene publication-title: Nature doi: 10.1038/383819a0 contributor: fullname: Matthes – volume: 25 start-page: 195 year: 2000 ident: ref_61 article-title: Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses publication-title: Nat. Genet. doi: 10.1038/76061 contributor: fullname: Filliol – volume: 37 start-page: 43 year: 2011 ident: ref_120 article-title: Anxiety sensitivity and illicit sedative use among opiate-dependent women and men publication-title: Am. J. Drug Alcohol. Abus. doi: 10.3109/00952990.2010.535581 contributor: fullname: Hearon – volume: 12 start-page: 9 year: 2022 ident: ref_116 article-title: Physical Activity for Health and Fitness: Past, Present and Future publication-title: J. Lifestyle Med. doi: 10.15280/jlm.2022.12.1.9 contributor: fullname: Kapoor – ident: ref_119 doi: 10.1186/s13102-022-00397-2 – volume: 66 start-page: 81 year: 2002 ident: ref_54 article-title: The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system publication-title: Prog. Neurobiol. doi: 10.1016/S0301-0082(01)00025-9 contributor: fullname: Lima – volume: 9 start-page: 97 year: 2016 ident: ref_122 article-title: From gene doping to athlete biological passport publication-title: Sport Sci. contributor: fullname: Mazzeo – volume: 41 start-page: 3085 year: 2020 ident: ref_114 article-title: Current application of cannabidiol (CBD) in the management and treatment of neurological disorders publication-title: Neurol. Sci. doi: 10.1007/s10072-020-04514-2 contributor: fullname: Fiani – volume: 30 start-page: 4806 year: 2010 ident: ref_95 article-title: Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5541-09.2010 contributor: fullname: Uchida – volume: 51 start-page: S75 year: 2021 ident: ref_133 article-title: Cannabis and Athletic Performance publication-title: Sports Med. doi: 10.1007/s40279-021-01505-x contributor: fullname: Burr – volume: 22 start-page: 440 year: 2018 ident: ref_102 article-title: Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation publication-title: Eur. J. Pain doi: 10.1002/ejp.1147 contributor: fullname: Wells – ident: ref_91 doi: 10.3389/fncel.2023.1328269 – ident: ref_9 doi: 10.3390/ijms24097831 – ident: ref_66 doi: 10.3389/fphar.2018.01388 – volume: 16 start-page: 545 year: 2017 ident: ref_64 article-title: Breaking barriers to novel analgesic drug development publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2017.87 contributor: fullname: Yekkirala – volume: 27 start-page: 339 year: 2023 ident: ref_113 article-title: The Exploration of Cannabis and Cannabinoid Therapies for Migraine publication-title: Curr. Pain Headache Rep. doi: 10.1007/s11916-023-01144-z contributor: fullname: Chandwani – volume: 33 start-page: 943 year: 2019 ident: ref_8 article-title: Opioid-Induced Tolerance and Hyperalgesia publication-title: CNS Drugs doi: 10.1007/s40263-019-00660-0 contributor: fullname: Mercadante – volume: 40 start-page: 29 year: 2002 ident: ref_56 article-title: The whole body receptive field of dorsal horn multireceptive neurones publication-title: Brain Res. Brain Res. Rev. doi: 10.1016/S0165-0173(02)00186-8 – volume: 37 start-page: 86 year: 2022 ident: ref_130 article-title: Musculoskeletal traumatic pain publication-title: DOLOR contributor: fullname: Antunes – volume: 104 start-page: 1623 year: 1987 ident: ref_28 article-title: Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection publication-title: J. Cell Biol. doi: 10.1083/jcb.104.6.1623 contributor: fullname: Heumann – volume: 138 start-page: 54 year: 2024 ident: ref_98 article-title: An Overview of Cannabidiol publication-title: Anesth. Analg. doi: 10.1213/ANE.0000000000006584 contributor: fullname: Sideris – volume: 238 start-page: 109597 year: 2023 ident: ref_5 article-title: Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2023.109597 contributor: fullname: Ochandarena – volume: 6 start-page: 607 year: 2021 ident: ref_71 article-title: Review of the Endocannabinoid System publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging contributor: fullname: Lu – volume: 13 start-page: 309 year: 2018 ident: ref_124 article-title: An investigation of drugs abuse in sport performance publication-title: J. Hum. Sport Exercise contributor: fullname: Mazzeo – volume: 16 start-page: 1059 year: 2018 ident: ref_75 article-title: Impact of Dietary Fats on Brain Functions publication-title: Curr. Neuropharmacol. doi: 10.2174/1570159X15666171017102547 contributor: fullname: Chianese – volume: 20 start-page: E755 year: 2017 ident: ref_107 article-title: Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials publication-title: Pain Physician doi: 10.36076/ppj.20.5.E755 contributor: fullname: Aviram – volume: 20 start-page: 2280113 year: 2023 ident: ref_127 article-title: A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS) publication-title: J. Int. Soc. Sports Nutr. doi: 10.1080/15502783.2023.2280113 contributor: fullname: Peters – volume: 8 start-page: 949 year: 2023 ident: ref_134 article-title: Cannabis Is Not Doping publication-title: Cannabis Cannabinoid Res. doi: 10.1089/can.2023.0012 contributor: fullname: Aguiar |
SSID | ssj0023259 |
Score | 2.461366 |
SecondaryResourceType | review_article |
Snippet | Pain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite... |
SourceID | doaj proquest crossref pubmed |
SourceType | Open Website Aggregation Database Index Database |
StartPage | 9407 |
SubjectTerms | Analgesics Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Animals Cannabidiol Cannabidiol - pharmacology Cannabidiol - therapeutic use cannabinoids Cannabinoids - pharmacology Cannabinoids - therapeutic use CB1 Chronic Pain - drug therapy Chronic Pain - metabolism Clinical medicine Endocannabinoids - metabolism Epigenesis, Genetic - drug effects Epigenetics Genes Humans Kinases Narcotics Nervous system Neurons opioids Oprm1 Pain Pain - drug therapy Pain - metabolism Pain Management - methods Receptors, Cannabinoid - metabolism Receptors, Opioid - metabolism Signal transduction Spinal cord |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEF5EELyIb-uLFfRmMNnsJl1vKpYiVHuw4C3MPgIRTYutiP_emWxaehEvXgppJslkJpv9vs3uN4ydQzeB0sc0S9whQXGJi7SEJAJnQFqflcrSeMfgMeuP5MOLelkq9UVzwoI8cAjcFTaCOLeqFNojuLYawOV4Mo84K0c4HKBRouZkqqVaqWjKpCXY-0SZ0lmY8p4iwb-qXt-njU6XpBKyS51Ro9n_O9BsOpzeJttokSK_CR5usRVfb7O1UDvye4d9PU2qceU41I7fQV0DUlzabiXIeVXzIbL-a07DTlSJiA_mlXD5wNN632qKZnT4aOrJvJUIfePDduXUJQ-LlC4bq141o9fiLhv17p_v-lFbRSGyCN1mESGyXBkhU4htV4FWRjlrBGgvM-NybcGQQK2IjXfCeW-Uj6XUXa1iQL6T7rHVelz7A8aNKRFOlF4CZBLwtyxtDqo0WY44TqcddjEPZzEJYhkFkgwKe7Ec9g67pVgvbEjiuvkDE1-0iS_-SnyHHc8zVbTtblrgHcsk7jbXOFvsxhZDn0Gg9uPPYIM4VWTo737I8MITRIt5mip5-B8eHrF1gRCIRqCFPmars49Pf4IQZmZOm6f1BwPV7PE priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELbYEBIvaMBghYGMBG-Nmjh2XO8FQUWZkAp7oFLfovOPTJlGUppOiP-eu8Tt9sJeIiW5RNbZPn_f2XfH2HuYZlCFlE6JeyQoPvOJkZAl4C1IF4pKOfJ3LL4X50v5baVW0eHWxWOVO5vYG2rfOvKRTxCGyCxFOqI_rn8nVDWKdldjCY0D9jCjTHgUKT7_uidcueiLpWW4BiWFMsVw8D1Hmj-pr351fbYuSYVk7yxJfeb-_8PNftmZH7EnES_yT0MHP2UPQvOMPRoqSP59zv78WNdt7Tk0ns-gaQCJLt3HROS8bvgFcv8zTs4nqkfEF7t6uHwRKOq37lCMPl92gcRjotBrfhHjp8Z8CFUa91LzekvG8Zgt519-zs6TWEshcai5bUK4TCsrZA6pmyowyirvrAATZGG9Ng4spakVqQ1e-BCsCqmUZmpUCsh68hfssGmbcMK4tRWCiipIgEICXqvKaVCVLTSiOZOP2IedOsv1kDKjRKpBai_vqn3EPpOu9zKU6Lp_0G4uyzhvSrSBqXaqEiYgt3IGwGscSwFhtkY2BCN2uuupMs6-rrwdKyP2bv8a5w1thkAT2ptBBtGqKLC9L4ce3rcEMaPOcyVf3f_z1-yxQIhDHmZhTtnhdnMT3iBE2dq3_Tj8B7wz5H4 priority: 102 providerName: ProQuest |
Title | Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness |
URI | https://www.ncbi.nlm.nih.gov/pubmed/39273354 https://www.proquest.com/docview/3104108407 https://www.proquest.com/docview/3104540263/abstract/ https://doaj.org/article/88707c5f29e548c9aad74a1e81d7255a |
Volume | 25 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9RAEF9qi-BL8dvTGlbQt0ZzyW42K4jY0rMIVw_x4N7C7EckUvfauyva_96ZTXIoKvgSSDJLNrNfv9_szgxjz6EaQ-MzOiXukKC4sUu1gHEKzoCwvmykJXvH9Kw8nYsPC7nYYUO20V6B679SO8onNV-dv_xxef0WB_wbYpxI2V-1X7-tY-QtQW7le7koBPX1qdjuJyBsiGnTyOCR0gTdHYH_o_Rvi1OM4f9v4BkXoMlttt8jR_6ua-o7bMeHu-xml0vy-h77_vGiXbaOQ3D8GEIApLx034ck523gM2jDa05mKMpMxKdDZlw-9eT_265RjIrP157E-5Ch53zWe1Id8s5p6TBKTdoNTZP32Xxy8vn4NO2zKqQWodwmJYSmpEEtQWYrCVoa6azJQXtRGqe0BUMBa_PMeJc77430mRC60jID5D_FA7YblsE_YtyYBuFF4wVAKQCvTWMVyMaUCnGdLkbsxaDO-qILnlEj6SC117-qfcSOSNdbGQp5HR8sV1_qfgTVOBtmysom1x5ZltUATmGv8gi4FfIiGLGDoaXqoRvV-MdinFXxG8-2r3EE0bYIBL-86mQQt-Yl1vdh18LbmiB6VEUhxeP_KP2E3coR8ZDBOdcHbHezuvJPEbFsTMJuqIXCazV5n7C9o5Oz2acksv-EVhKZxM76E7b17n8 |
link.rule.ids | 315,786,790,870,2115,2236,12083,12792,21416,24346,27955,27956,31752,31753,33406,33407,33777,33778,43343,43633,43838,74100,74390,74657 |
linkProvider | Scholars Portal |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKwQXxLMsFDAS3Bo1cex4zQXRqqsFussKdaXeovEjKAiSpdkK8e-ZSbxLL3CJlGQSWePX943tbxh7DZMMqpDSLnGPBMVnPjESsgS8BelCUSlH8Y75opit5McLdREDbl3cVrkdE_uB2reOYuRHCENkliId0e_WPxPKGkWrqzGFxk22R5KbkxHbOz5dLL_sKFcu-nRpGc5CSaFMMWx9z5HoH9XffnS9XpekVLLXJqVeu__fgLOfeKb32N2IGPn7oYrvsxuhecBuDTkkfz9kvz6v67b2HBrPT6BpAKku3Ucpcl43fIns_y2n8BNlJOLzbUZcPg907rfu0Iw-X3WBzKNU6He-jCeoDvlwWOmwt5rWGxoeH7HV9PT8ZJbEbAqJQ99tEkJmWlkhc0jdRIFRVnlnBZggC-u1cWBJqFakNnjhQ7AqpFKaiVEpIO_JH7NR0zbhCePWVggrqiABCgl4rSqnQVW20IjnTD5mb7buLNeDaEaJZIPcXl53-5gdk693NiR13T9oL7-WseeUOAqm2qlKmIDsyhkAr7E1BQTaGvkQjNnBtqbK2P-68m9rGbNXu9fYc2g5BJrQXg02iFdFgeXdH2p4VxJEjTrPlXz6_5-_ZLdn5_Oz8uzD4tMzdkcg4KF4szAHbLS5vArPEbBs7IvYKv8Ajxro1Q |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCMQF8SxbChgJbo02Dztec0FtYVUeW_bASnuLxq8qFSTbZivEv2cm8W57gUukJJPIGr--zx7Px9hbmGQQfEpR4g4JistcogVkCTgDwvoySEvrHbPT8mQhvizlMsY_dTGscjMm9gO1ay2tkY8RhogsRTqixiGGRcw_Tj-sLhJSkKKd1iincZvdwVkyJRkHtbwmX0XeC6dlOB8lpdTlEARfIOUf1-e_uj5zlyBR2RvTU5_F_9_Qs5-Cpg_Zg4gd-eFQ2Y_YLd88ZncHNck_T9jv76u6rR2HxvFjaBpA0kv3MSk5rxs-h7p5z2khirSJ-Gyjjctnnk4A1x2a0eeLzpN5TBr6k8_jWaoDPhxbOuitpvWaBsqnbDH99OP4JIm6ColFL64TwmhKmlwUkNqJBC2NdNbkoL0ojVPagqGUtXlqvMud90b6VAg90TIFZEDFM7bTtI1_zrgxAQFG8AKgFIDXEKwCGUypENnpYsTebdxZrYb0GRXSDnJ7ddPtI3ZEvt7aUNLr_kF7eVbFPlTheJgqK0OuPfIsqwGcwnblEXIrZEYwYvubmqpiT-yq63YzYm-2r7EP0cYINL69GmwQueYllnd3qOFtSRA_qqKQYu__P3_N7mFzrL59Pv36gt3PEfnQwnOu99nO-vLKv0Tksjav-ib5F1C665I |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Opioid+and+Cannabinoid+Systems+in+Pain%3A+Emerging+Molecular+Mechanisms+and+Use+in+Clinical+Practice%2C+Health%2C+and+Fitness&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Secondulfo%2C+Carmine&rft.au=Mazzeo%2C+Filomena&rft.au=Pastorino%2C+Grazia+Maria+Giovanna&rft.au=Vicidomini%2C+Antonella&rft.date=2024-08-29&rft.issn=1422-0067&rft.eissn=1422-0067&rft.volume=25&rft.issue=17&rft_id=info:doi/10.3390%2Fijms25179407&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |