Merging C–H and C–C bond cleavage in organic synthesis

• Published in: Nature reviews. Chemistry Vol. 1; no. 5
• Main Authors: Nairoukh, Zackaria, Cormier, Morgan, Marek, Ilan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2017; Nature Publishing Group
• Subjects: 639/638/403/933; 639/638/403/935; Analytical Chemistry; Biochemistry; Cascade chemical reactions; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Cleavage; Complexity; Covalent bonds; Functional groups; Hydrogen bonds; Inorganic Chemistry; Molecular structure; Organic Chemistry; Physical Chemistry; review-article

Metal-catalysed functionalization of a carbon–hydrogen bond can occur selectively even in the presence of ostensibly more reactive functional groups. Such conversions have changed our perceptions of organic chemistry because we can now consider a C–H bond as a functional group, the reactions of whic...