Antioxidant and Neuroprotective Effects of L-arginine Administration After Traumatic Brain Injury and Hemorrhagic Shock in Rats

• Published in: Turkish neurosurgery Vol. 33; no. 3; pp. 379 - 385
• Main Authors: Berikol, Goksu Bozdereli, Berikol, Gurkan, Ayrik, Cuneyt, Kose, Ataman, Babus, Seyran Bozkurt, Gumus, Lulufer Tamer, Arpaci, Rabia Bozdogan, Dag, Ahmet, Ayan, Erhan, Gorur, Aysegul
• Format: Journal Article
• Language: English
• Published: Turkey 01.01.2023
• Subjects: Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Arginine - pharmacology; Arginine - therapeutic use; Brain Injuries, Traumatic - drug therapy; Lactates; Neuroprotective Agents - pharmacology; Rats; Shock, Hemorrhagic - drug therapy; Sodium Chloride

To investigate the effect of fluid resuscitation and L-arginine administration on oxidant status markers, blood gases, lactate and apoptosis in the brain tissue of a rat model of TBI with hemorrhagic shock. A total of 60 rats were divided into six groups: control, isotonic saline-treated, 7.5% NaCl-...