Dose-response association of resting heart rate and hypertension in adults: A systematic review and meta-analysis of cohort studies
The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association. We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combi...
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Published in | Medicine (Baltimore) Vol. 99; no. 10; p. e19401 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.03.2020
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Abstract | The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association.
We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship.
Nine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06-1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55.5 beats per minute, the risk of hypertension significantly increased with increasing levels of RHR (Pnonlinearity = 0.059).
We found a linear dose-response association between RHR and incident hypertension in adults. |
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AbstractList | Abstract
Background:
The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association.
Methods:
We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship.
Results:
Nine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06–1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55.5 beats per minute, the risk of hypertension significantly increased with increasing levels of RHR (
P
nonlinearity
= 0.059).
Conclusion:
We found a linear dose-response association between RHR and incident hypertension in adults. Supplemental Digital Content is available in the text The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association. We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship. Nine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06-1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55.5 beats per minute, the risk of hypertension significantly increased with increasing levels of RHR (Pnonlinearity = 0.059). We found a linear dose-response association between RHR and incident hypertension in adults. |
Author | Han, Chengyi Jiang, Xuesong Wang, Yuming Ren, Yongcheng Yang, Yongguang Shen, Lijun |
AuthorAffiliation | b The First Affiliated Hospital of Henan University of CM, Zhengzhou c Huanghuai University, Zhumadian, Henan, China a Henan Provincial Peoples Hospital, Zhengzhou |
AuthorAffiliation_xml | – name: c Huanghuai University, Zhumadian, Henan, China – name: a Henan Provincial Peoples Hospital, Zhengzhou – name: b The First Affiliated Hospital of Henan University of CM, Zhengzhou |
Author_xml | – sequence: 1 givenname: Lijun surname: Shen fullname: Shen, Lijun organization: Henan Provincial Peoples Hospital, Zhengzhou – sequence: 2 givenname: Yuming surname: Wang fullname: Wang, Yuming organization: Henan Provincial Peoples Hospital, Zhengzhou – sequence: 3 givenname: Xuesong surname: Jiang fullname: Jiang, Xuesong organization: The First Affiliated Hospital of Henan University of CM, Zhengzhou – sequence: 4 givenname: Yongcheng surname: Ren fullname: Ren, Yongcheng organization: Huanghuai University, Zhumadian, Henan, China – sequence: 5 givenname: Chengyi surname: Han fullname: Han, Chengyi organization: The First Affiliated Hospital of Henan University of CM, Zhengzhou – sequence: 6 givenname: Yongguang surname: Yang fullname: Yang, Yongguang organization: Henan Provincial Peoples Hospital, Zhengzhou |
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Cites_doi | 10.1111/j.1365-2796.2004.01403.x 10.1016/j.numecd.2015.02.008 10.1093/aje/kwh142 10.1097/00001648-199507000-00005 10.1007/s00592-013-0503-9 10.1016/j.ehj.2003.12.003 10.1097/HJH.0000000000001627 10.1253/circj.71.1755 10.1136/heartjnl-2015-309119 10.1093/aje/kwn005 10.1016/0002-8703(85)90087-0 10.1161/01.HYP.14.1.28 10.1097/HJH.0000000000000230 10.1161/01.HYP.24.5.585 10.1161/01.HYP.31.1.409 10.1016/j.numecd.2017.04.004 10.1038/sj.jhh.1000740 10.1161/01.HYP.0000251679.87348.05 10.1093/aje/kwr265 10.1097/HJH.0000000000001023 10.1536/ihj.18-470 10.1016/0091-7435(86)90007-1 10.1016/j.pcad.2009.05.004 10.1097/HJH.0b013e328013e7f4 10.1093/ajh/hpv095 10.1093/eurheartj/eht151 10.1172/JCI119532 10.1177/1536867X0600600103 10.1503/cmaj.150535 10.1007/s00592-016-0942-1 10.1016/0197-2456(86)90046-2 10.2337/diab.46.12.2040 10.1016/j.cca.2016.01.006 10.1146/annurev.psych.47.1.113 10.1038/ajh.2008.331 10.1161/01.HYP.19.2.183 |
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Snippet | The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the... Abstract Background: The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies... Supplemental Digital Content is available in the text |
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SubjectTerms | Adult Cohort Studies Dose-Response Relationship, Drug Heart Rate - drug effects Heart Rate - physiology Heart Rate Determination - methods Humans Hypertension - drug therapy Hypertension - physiopathology Risk Factors Systematic Review and Meta-Analysis |
Title | Dose-response association of resting heart rate and hypertension in adults: A systematic review and meta-analysis of cohort studies |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32150086 https://pubmed.ncbi.nlm.nih.gov/PMC7478507 |
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