Functionalised nanoformulation of Swertiamarin with enhanced stability and hemocompatibility: synthesis, characterisation and anticancer evaluation

• Published in: Materials technology (New York, N.Y.) Vol. 36; no. 7; pp. 440 - 449
• Main Authors: P K, Gayathri, K, Sathish Kumar
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 07.06.2021
• Subjects: Functionalised nanocarrier; good Stability; hemocompatibility; hepg2 cell lines; nanoformulation; sem analysis; swertiamarin
• DOI: 10.1080/10667857.2020.1769260
• ISSN: 1066-7857

This study aimed to enhance the stability and compatibility of swertiamarin by loading it on amino-functionalised graphene oxide (GO) by ultrasonication. The nanoformulation showed a new peak in the FTIR spectrum (1658 cm −1 ) and a coupled peak in the UV-Vis spectrum implying CO-NH 2 interaction between swertiamarin and functionalised GO. The SEM image revealed a sheet-like appearance with an average particle size of 252.38 ± 86.09 nm. The nanoformulation was non-haemolytic at 200 μg/mL (<5%) whereas swertiamarin was haemolytic at 50 μg/mL concentration. The freeze-dried samples exhibited good stability at normal storage condition. The formulation and the swertiamarin displayed similar anticancer activity against HepG2 cell lines with an average IC 50 value of 110 ± 0.75 μg/mL, respectively. Hence, the functionalised GO can be considered as a compatible carrier for bioactive compounds which provides better hemocompatibility and stability.