MTERF3 contributes to MPP+-induced mitochondrial dysfunction in SH-SY5Y cells

• Published in: Acta biochimica et biophysica Sinica Vol. 54; no. 8; pp. 1113 - 1121
• Main Authors: Zhu, Shun, Xu, Nan, Han, Yanyan, Ye, Xiaofei, Yang, Ling, Zuo, Ji, Liu, Wen
• Format: Journal Article
• Language: English
• Published: China China Science Publishing & Media Ltd 25.08.2022
• Subjects: 1-Methyl-4-phenylpyridinium - metabolism; 1-Methyl-4-phenylpyridinium - toxicity; Animals; Apoptosis; Cell Line, Tumor; degenerative disease; DNA, Mitochondrial - genetics; environmental toxins; Humans; Mice; Mitochondria - metabolism; mitochondrial dysfunction; MTERF3; Neuroblastoma - pathology; Parkinson’s disease; Transcription, Genetic; mitochondrial dysfunction; MTERF3; environmental toxins; Parkinson’s disease; degenerative disease
• ISSN: 1672-9145; 1745-7270; 1745-7270
• DOI: 10.3724/abbs.2022098

Parkinson's disease (PD) is a neurodegenerative disorder causing severe social and economic burdens. The origin of PD has been usually attributed to mitochondrial dysfunction. To this end, mitochondrial transcription regulators become attractive subjects for understanding PD pathogenesis. Previ...