Analysis of Meis2 knockout mice reveals Sonic hedgehog‐mediated patterning of the cochlear duct

• Published in: Developmental dynamics Vol. 254; no. 4; pp. 365 - 372
• Main Authors: Koo, Hei Yeun, Oh, Jae Hwan, Durán Alonso, María Beatriz, Hernández, Iris López, González‐Vallinas, Margarita, Alonso, María Teresa, Tena, Juan J., Gil‐Gálvez, Alejandro, Giraldez, Fernando, Bok, Jinwoong, Schimmang, Thomas
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2025; Wiley Subscription Services, Inc
• Subjects: Abnormalities; Animals; Body Patterning - genetics; Cochlea; Cochlear Duct - embryology; Cochlear Duct - metabolism; Coiling; Gene Expression Regulation, Developmental; Genes; hair cell; Hair cells; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; inner ear; Meis; Mice; Mice, Knockout; Morphology; Mutants; otic vesicle; Phenotypes; Signal Transduction; sonic hedgehog; Transcription Factors - genetics; Transcription Factors - metabolism; sonic hedgehog; cochlea; otic vesicle; inner ear; Meis; hair cell

Background The mechanisms underlying the formation of complex structures such as during the outgrowth of the cochlear duct are still poorly understood. Results We have analyzed the morphological and molecular changes associated with cochlear development in mouse mutants for the transcription factor...