Integrin β3 Deficiency Results in Hypertriglyceridemia via Disrupting LPL (Lipoprotein Lipase) Secretion

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 40; no. 5; pp. 1296 - 1310
• Main Authors: Xiao, Bing, Mao, Jianhua, Sun, Boyang, Zhang, Wei, Wang, Yun, Wang, Pengran, Ruan, Zheng, Xi, Wenda, Li, Huiyuan, Zhou, Jingyi, Lu, Yide, Ding, Qiulan, Wang, Xuefeng, Liu, Jingqiu, Yan, Jinsong, Luo, Cheng, Shi, Xiaofeng, Yang, Renchi, Xi, Xiaodong
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.05.2020
• Subjects: protein kinase D; integrins; thrombasthenia; lipoprotein lipase; lipoproteins

OBJECTIVE:Integrin β3 is implicated in numerous biological processes such as its relevance to blood triglyceride, yet whether β3 deficiency affects this metabolic process remains unknown. APPROACH AND RESULTS:We showed that the Chinese patients with β3-deficient Glanzmann thrombasthenia had a 2-fold...