Structural insights into type III polyketide synthase CylI from cylindrocyclophane biosynthesis

• Published in: Protein science Vol. 33; no. 10; pp. e5130 - n/a
• Main Authors: Wang, Hua‐Qi, Xiang, Zheng
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2024; Wiley Subscription Services, Inc
• Subjects: Aldehydes; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biosynthesis; Catalytic Domain; Condensates; Crystal structure; Crystallography, X-Ray; Cyanobacteria; Cyanobacteria - enzymology; Cyanobacteria - genetics; Cyanobacteria - metabolism; cylindrocyclophanes; mechanism; Models, Molecular; Mutagenesis; Natural products; Polyketide synthase; Polyketide Synthases - chemistry; Polyketide Synthases - genetics; Polyketide Synthases - metabolism; Protein Conformation; Residues; Structural analysis; Structural members; structure; Substrate preferences; Substrate Specificity; Substrates; polyketide synthase; cylindrocyclophanes; mechanism; structure; biosynthesis

Type III polyketide synthases (PKSs) catalyze the formation of a variety of polyketide natural products with remarkable structural diversity and biological activities. Despite significant progress in structural and mechanistic studies of type III PKSs in bacteria, fungi, and plants, research on type...