OphthalMimic: A new alternative apparatus without animal tissue for the evaluation of topical ophthalmic drug products

• Published in: Methods (San Diego, Calif.) Vol. 228; pp. 1 - 11
• Main Authors: Barbalho, Geisa N., Falcão, Manuel A., Alves Amaral, Venâncio, Contarato, Jonad L.A., Barbalho, Aliucha M., Kaori Diógenes, Gabriela, Mariana Gomes Silva, Melyssa, Carvalho de Barros do Vale Rochelle, Beatriz, Gelfuso, Guilherme M., Cunha-Filho, Marcilio, Gratieri, Tais
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2024
• Subjects: 3D-printed device; Administration, Ophthalmic; Animal Testing Alternatives - methods; Animals; Chitosan - chemistry; Cornea - drug effects; Cornea - metabolism; Drug delivery; Fluconazole - administration & dosage; Gelatin - chemistry; Humans; Ocular delivery; Ophthalmic Solutions - chemistry; Poloxamer - chemistry; Polymeric membrane; Printing, Three-Dimensional; Retention time; Tears - chemistry; Polymeric membrane; Drug delivery; Retention time; Ocular delivery; 3D-printed device

•Novel in vitro methods are necessary to substitute costly, slow, and highly complexin vivomodels to evaluate ophthalmic formulations.•The efficacy of topical ophthalmic drug products depends directly on formulation residence time in the eye, which must be sufficient for the drug to penetrate the co...