The acute effects of methoxphenidine on behaviour and pharmacokinetics profile in animal model

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 137; p. 111285
• Main Authors: Štefková-Mazochová, Kristýna, Danda, Hynek, Mazoch, Vladimír, Olejníková-Ladislavová, Lucie, Šíchová, Klára, Paškanová, Natálie, Vágnerová, Magdaléna, Jurásek, Bronislav, Ryšánek, Pavel, Šíma, Martin, Šafanda, Adam, Bui, Quang Hiep, Kuchař, Martin, Páleníček, Tomáš
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 20.03.2025
• Subjects: Animals; Behavior, Animal - drug effects; Brain - drug effects; Brain - metabolism; Brain - pathology; Cyclohexanones - pharmacokinetics; Cyclohexylamines - pharmacokinetics; Cyclohexylamines - pharmacology; Cyclohexylamines - toxicity; Dose-Response Relationship, Drug; Locomotion - drug effects; Male; Methoxphenidine; Motor Activity - drug effects; Open field; Pharmacokinetics; Prepulse Inhibition - drug effects; Psychotropic Drugs - pharmacokinetics; Psychotropic Drugs - pharmacology; Rats; Rats, Wistar; Systemic toxicity; Wistar rats; Wistar rats; Methoxphenidine; Pharmacokinetics; Open field; Systemic toxicity

Methoxphenidine (MXP) is classified as a new psychoactive substance that has recently emerged on the illicit drug market. Understanding the pharmacological and behavioural profiles of newly emerging drugs is essential for a better understanding of their psychotropic effects and potential toxicity. T...