Allelic imbalance on 16q in small, unifocal hepatocellular carcinoma : Correlation with HBV and HCV infections and cellular proliferation rate

• Published in: Digestive diseases and sciences Vol. 45; no. 2; pp. 306 - 311
• Main Authors: GRAMANTIERI, L, TRERE, D, PESSION, A, PISCAGLIA, F, MASI, L, GAIANI, S, MAZZIOTTI, A, BOLONDI, L
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.02.2000; Springer Nature B.V
• Subjects: Aged; Alleles; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Cell Division; Chromosomes, Human, Pair 16; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis B - genetics; Hepatitis C - genetics; Humans; Liver Neoplasms - genetics; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Loss of Heterozygosity; Male; Medical sciences; Microsatellite Repeats; Middle Aged; Nucleolus Organizer Region; Tumors; Human; Pathogenesis; Loss; Hepatic disease; Hepatocellular carcinoma; Early stage; Malignant tumor; Incidence; Infection; Viral hepatitis B; Allele; Concomitant disease; Chromosome E16; Viral disease; Predisposition; Digestive diseases; Genetics; Tumor suppressor gene

In advanced hepatocellular carcinoma (HCC), allelic loss on chromosome 16q may occur. To better define the frequency of this alteration in small HCC and to more closely identify the affected region for further positional cloning of the putative tumor suppressor gene contained in this region, microsa...