Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

• Published in: Diabetes care Vol. 41; no. 6; pp. 1235 - 1243
• Main Authors: Apostolopoulou, Maria, Gordillo, Ruth, Koliaki, Chrysi, Gancheva, Sofia, Jelenik, Tomas, De Filippo, Elisabetta, Herder, Christian, Markgraf, Daniel, Jankowiak, Frank, Esposito, Irene, Schlensak, Matthias, Scherer, Philipp E., Roden, Michael
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.06.2018
• Subjects: Abdominal surgery; Adult; Animals; c-Jun protein; Ceramide; Clamps; Correlation; Disease Progression; Fatty liver; Female; Glucose Clamp Technique; Humans; Inflammation; Inflammation - blood; Inflammation - metabolism; Inflammation - physiopathology; Insulin; Insulin resistance; Insulin Resistance - physiology; JNK protein; Lipid metabolism; Lipid peroxidation; Lipid Peroxidation - physiology; Lipids; Liver; Liver - chemistry; Liver - metabolism; Liver - pathology; Liver diseases; Male; Metabolism; Metabolites; Middle Aged; Mitochondria; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - physiopathology; Obesity - blood; Obesity - metabolism; Obesity - physiopathology; Obesity - surgery; Oxidation resistance; Oxidation-Reduction; Oxidative stress; Oxidative Stress - physiology; Peroxidation; Peroxides; Prospective Studies; Research design; Sensitivity; Sphinganine; Sphingolipids; Sphingolipids - analysis; Sphingolipids - blood; Sphingolipids - metabolism; Sphingomyelin; Steatosis; Surgery; Transcription factors

Insulin resistance and nonalcoholic fatty liver disease have been linked to several lipid metabolites in animals, but their role in humans remains unclear. This study examined the relationship of sphingolipids with hepatic and peripheral metabolism in 21 insulin-resistant obese patients without (NAF...