In vitro liver models for toxicological research

• Published in: Drug metabolism and pharmacokinetics Vol. 62; p. 101478
• Main Authors: Fukunaga, Ichiro, Takebe, Takanori
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2025
• Subjects: 3D culture; Animals; Chemical and Drug Induced Liver Injury - metabolism; DILI; HepaRG; Hepatocytes - drug effects; Hepatocytes - metabolism; HepG2; Human liver organoid; Humans; In vitro liver model; Liver - drug effects; Liver - metabolism; Models, Biological; Organoids - drug effects; Organoids - metabolism; Pluripotent stem cell; Primary hepatocytes; Toxicity Tests - methods; DILI; 3D culture; HepaRG; Pluripotent stem cell; Primary hepatocytes; HepG2; Human liver organoid; In vitro liver model

Drug-induced liver injury (DILI) presents a major challenge not only in new drug development but also in post-marketing withdrawals and the safety of food, cosmetics, and chemicals. Experimental model organisms such as the rodents have been widely used for preclinical toxicological testing. However,...