Doxycycline mitigates corneal fibrosis by suppressing the focal adhesion pathway

• Published in: Experimental eye research Vol. 258; p. 110506
• Main Authors: Zhou, Jiaxin, He, Bingbing, Zou, Wenjin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2025
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Burns, Chemical - drug therapy; Burns, Chemical - metabolism; Burns, Chemical - pathology; Cornea - drug effects; Cornea - metabolism; Cornea - pathology; Corneal alkali burn; Corneal fibroblast; Disease Models, Animal; Doxycycline; Doxycycline - pharmacology; Doxycycline - therapeutic use; Eye Burns - chemically induced; Eye Burns - drug therapy; Eye Burns - metabolism; Eye Burns - pathology; Fibronectins - metabolism; Fibrosis - prevention & control; Focal adhesion pathway; Focal Adhesions - drug effects; Focal Adhesions - metabolism; Male; Ophthalmic Solutions; Rabbits; Signal Transduction - drug effects; Sodium Hydroxide - toxicity; Wound Healing - drug effects; Focal adhesion pathway; Corneal fibroblast; Corneal alkali burn; Doxycycline

The cornea, as a key barrier of intraocular tissues, is vulnerable to various injury factors. Acute alkali burns, as an ophthalmic emergency, can cause serious pathological changes such as persistent corneal epithelial defects, ulcers and even perforations. Doxycycline has been proven to have inhibi...