Detection of HTLV-1 proviral DNA in BM mononuclear cells and cultured mesenchymal stromal cells isolated from patients with HTLV-1 infection
The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4+ T-cell lymphocytes in the BM of HTLV-1-infected individuals was obser...
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| Published in | Virology (New York, N.Y.) Vol. 519; pp. 145 - 155 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
01.06.2018
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| Abstract | The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4+ T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4+ T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls. Isolated HTLV-1 infected BM-MSC demonstrated surface expression markers and in vitro differentiation potential similar to uninfected individuals. The presence of HTLV-1 proviral DNA in the BM-MSC of HTLV-1-infected patients was demonstrated but no p19 antigen was detected in supernatant from cultured MSC. We suppose that HTLV-1 infects human MSC probably by cell-to-cell contact from the infected CD4+ T-lymphocytes infiltrated into the bone marrow.
•The number of CD4+ T cells is higher in bone marrow of HTLV-1-symptomatic infected individuals when compared to healthy controls.•The bone marrow of HTLV-1-infected individuals showed Tax-expressing CD4+ T cells.•Mesenchymal stem cells (MSCs) frequency to form fibroblast progenitors was significantly lower in bone marrow cells obtained from HTLV-1 infected patients.•MSC isolated from BM of HTLV-1-infected individuals contained HTLV-1 provirus. |
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| AbstractList | The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4
T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4
T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls. Isolated HTLV-1 infected BM-MSC demonstrated surface expression markers and in vitro differentiation potential similar to uninfected individuals. The presence of HTLV-1 proviral DNA in the BM-MSC of HTLV-1-infected patients was demonstrated but no p19 antigen was detected in supernatant from cultured MSC. We suppose that HTLV-1 infects human MSC probably by cell-to-cell contact from the infected CD4
T-lymphocytes infiltrated into the bone marrow. The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4+ T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4+ T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls. Isolated HTLV-1 infected BM-MSC demonstrated surface expression markers and in vitro differentiation potential similar to uninfected individuals. The presence of HTLV-1 proviral DNA in the BM-MSC of HTLV-1-infected patients was demonstrated but no p19 antigen was detected in supernatant from cultured MSC. We suppose that HTLV-1 infects human MSC probably by cell-to-cell contact from the infected CD4+ T-lymphocytes infiltrated into the bone marrow. •The number of CD4+ T cells is higher in bone marrow of HTLV-1-symptomatic infected individuals when compared to healthy controls.•The bone marrow of HTLV-1-infected individuals showed Tax-expressing CD4+ T cells.•Mesenchymal stem cells (MSCs) frequency to form fibroblast progenitors was significantly lower in bone marrow cells obtained from HTLV-1 infected patients.•MSC isolated from BM of HTLV-1-infected individuals contained HTLV-1 provirus. The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4+ T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4+ T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls. Isolated HTLV-1 infected BM-MSC demonstrated surface expression markers and in vitro differentiation potential similar to uninfected individuals. The presence of HTLV-1 proviral DNA in the BM-MSC of HTLV-1-infected patients was demonstrated but no p19 antigen was detected in supernatant from cultured MSC. We suppose that HTLV-1 infects human MSC probably by cell-to-cell contact from the infected CD4+ T-lymphocytes infiltrated into the bone marrow. |
| Author | Otaguiri, Katia Kaori de Macedo, Mayra Dorigan Kashima, Simone Rodrigues, Evandra Strazza Orellana, Maristela Delgado Palma, Patrícia Vianna Bonini Covas, Dimas Tadeu Slavov, Svetoslav Nanev Takayanagui, Osvaldo Massaiti do Carmo Favarin, Maria |
| Author_xml | – sequence: 1 givenname: Evandra Strazza surname: Rodrigues fullname: Rodrigues, Evandra Strazza organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 2 givenname: Maria surname: do Carmo Favarin fullname: do Carmo Favarin, Maria organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 3 givenname: Mayra Dorigan surname: de Macedo fullname: de Macedo, Mayra Dorigan organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 4 givenname: Katia Kaori surname: Otaguiri fullname: Otaguiri, Katia Kaori organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 5 givenname: Maristela Delgado surname: Orellana fullname: Orellana, Maristela Delgado organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 6 givenname: Osvaldo Massaiti surname: Takayanagui fullname: Takayanagui, Osvaldo Massaiti organization: Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil – sequence: 7 givenname: Patrícia Vianna Bonini surname: Palma fullname: Palma, Patrícia Vianna Bonini organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 8 givenname: Svetoslav Nanev surname: Slavov fullname: Slavov, Svetoslav Nanev organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 9 givenname: Dimas Tadeu surname: Covas fullname: Covas, Dimas Tadeu organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil – sequence: 10 givenname: Simone surname: Kashima fullname: Kashima, Simone email: skashima@hemocentro.fmrp.usp.br organization: Regional Blood Center of Ribeirão Preto, University of São Paulo, Brazil |
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| Keywords | Human mesenchymal stromal cell Virus infection HTLV-1 MSC Provirus |
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| Title | Detection of HTLV-1 proviral DNA in BM mononuclear cells and cultured mesenchymal stromal cells isolated from patients with HTLV-1 infection |
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