Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating CD9 and PLEKHG6

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 29; no. 4; pp. 850 - 859
• Main Authors: Ke, Juntao, Tian, Jianbo, Mei, Shufang, Ying, Pingting, Yang, Nan, Wang, Xiaoyang, Zou, Danyi, Peng, Xiating, Yang, Yang, Zhu, Ying, Gong, Yajie, Wang, Zhihua, Gong, Jing, Zhong, Rong, Chang, Jiang, Miao, Xiaoping
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020

Genome-wide association studies (GWAS) have identified dozens of loci associated with colon and rectal adenocarcinoma risk. As tissue-specific super-enhancers (SE) play important roles in tumorigenesis, we systematically investigate SEs and inner variants in established GWAS loci to decipher the und...