Recent advances in asymmetric synthesis of pipecolic acid and derivatives

This review covers the literature relating to asymmetric syntheses of pipecolic acid derivatives from 1997 to present. This review is organized according to the position and the degree of substitution of the piperidinic cycle. In a first section, syntheses of pipecolic acid itself are described. The...

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Bibliographic Details
Published inAmino acids Vol. 29; no. 2; pp. 101 - 130
Main Authors Kadouri-Puchot, C, Comesse, S
Format Journal Article
LanguageEnglish
Published Austria Springer Nature B.V 01.08.2005
Springer Verlag
Subjects
Acids
Amino acids
Amino Alcohols - chemistry
Asymmetry
Chemical Sciences
Derivatives
Imidazolidines - chemistry
Lactones - chemistry
Photochemistry
Pipecolic Acids - chemical synthesis
Stereoisomerism
Synthesis
Unsaturated
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Summary:This review covers the literature relating to asymmetric syntheses of pipecolic acid derivatives from 1997 to present. This review is organized according to the position and the degree of substitution of the piperidinic cycle. In a first section, syntheses of pipecolic acid itself are described. Then, successively, syntheses of C-3, C-4, C-5, C-6 substituted pipecolic acid derivatives are reported. Finally, syntheses of unsaturated pipecolic acid derivatives are presented before the last part devoted to the polysubstituted pipecolic acid derivatives.
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ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-005-0193-x