IGSF8 impairs migration and invasion of trophoblast cells and angiogenesis in preeclampsia

• Published in: Experimental cell research Vol. 445; no. 1; p. 114405
• Main Authors: Chu, Xiaodan, Chen, Xuan, Guo, Man, Li, Xinyue, Qu, Zhihai, Li, Peiling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2025
• Subjects: Angiogenesis; Animals; Cell Movement - genetics; Disease Models, Animal; Epithelial-Mesenchymal Transition - genetics; Female; Humans; IGSF8; Membrane Proteins - genetics; Membrane Proteins - metabolism; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Placenta - metabolism; Placenta - pathology; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Trophoblast cell infiltration; Trophoblasts - metabolism; Trophoblasts - pathology; IGSF8; Angiogenesis; Trophoblast cell infiltration; Preeclampsia

Insufficient trophoblast cell infiltration is implicated in the progression of preeclampsia (PE). The immunoglobulin superfamily member 8 (IGSF8) has been shown to promote cell migration, invasion, and epithelial mesenchymal transition (EMT). However, the specific impact of IGSF8 on trophoblast cell...